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cpnA cpnA ChLim ChLim dennd10 dennd10 DDB0190346 DDB0190346 rab4 rab4 DDB0183788 DDB0183788 DDB0188631 DDB0188631 DDB0188195 DDB0188195 DDB0187675 DDB0187675 Dnajc13 Dnajc13 DDB0229348 DDB0229348 DDB_G0285969 DDB_G0285969 erkB erkB gacG gacG DDB0185316 DDB0185316 rabV rabV rabS rabS drkD drkD pdkA pdkA far1 far1 DDB0218242 DDB0218242 pldB pldB sarB sarB ndrA ndrA DDB0205392 DDB0205392 elmoA elmoA rheb rheb abpE-1 abpE-1 sarA sarA DDB0190759 DDB0190759 ripA ripA myoK myoK racH racH cshA cshA paxB paxB rapA rapA rab8A rab8A rab8B rab8B ndkC-1 ndkC-1 proA proA proB proB pkgB pkgB rasB rasB rasS rasS gpaD gpaD pkaC pkaC rab21 rab21 gpbA gpbA rab2A rab2A rab14 rab14 rab7A rab7A pkbA pkbA pikA pikA pikB pikB plc plc rabZ rabZ DDB_G0294557 DDB_G0294557 forG forG fcsB fcsB DDB_G0293920 DDB_G0293920 DDB_G0292878 DDB_G0292878 lst8 lst8 carA-1 carA-1 phgA phgA piaA piaA gefB gefB p2xA p2xA lvsB lvsB limF limF rpkA rpkA pakB pakB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cpnACopine-A; Required for cytokinesis, contractile vacuole function and development; Belongs to the copine family. (600 aa)
ChLimCalponin homology and LIM domain-containing protein; Involved in the regulation of phagocytosis. May repress rab21. (686 aa)
dennd10DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) which may be involved in the regulation of homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. (366 aa)
DDB0190346C2 domain-containing protein. (1546 aa)
rab4Ras-related protein Rab-4; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (205 aa)
DDB0183788PKD_channel domain-containing protein. (823 aa)
DDB0188631V-SNARE coiled-coil homology domain-containing protein. (1093 aa)
DDB0188195Ras-GAP domain-containing protein. (817 aa)
DDB0187675Uncharacterized protein. (920 aa)
Dnajc13J domain-containing protein. (2592 aa)
DDB0229348WD-40 repeat-containing protein. (469 aa)
DDB_G0285969Protein DJ-1 homolog; Protects cells against oxidative stress and cell death. (205 aa)
erkBExtracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa)
gacGRho GTPase-activating protein gacG; Rho GTPase-activating protein involved in the signal transduction pathway. (1312 aa)
DDB0185316Uncharacterized protein. (222 aa)
rabVRas-related protein RabV; Belongs to the small GTPase superfamily. Rab family. (233 aa)
rabSRas-related protein RabS. (221 aa)
drkDProbable serine/threonine-protein kinase drkD; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1288 aa)
pdkAProbable serine/threonine-protein kinase pdkA. (686 aa)
far1Metabotropic glutamate receptor-like protein L; In the C-terminal section; belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. (708 aa)
DDB0218242Rap-GAP domain-containing protein. (2935 aa)
pldBPhospholipase D B; Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization. Plays an important role in cell migration by localizing along the anterior cell membrane. Overexpression leads to the inability to aggregate even at higher cell density. Also known as a negative regulator of quorum sensing. (1216 aa)
sarBGTP-binding protein Sar1B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (194 aa)
ndrAProbable serine/threonine-protein kinase ndrA. (530 aa)
DDB0205392Uncharacterized protein. (996 aa)
elmoAELMO domain-containing protein A; Functions as a negative regulator of actin polymerization. Modulates actin/myosin II at cortex actinomyosins to prevent excessive F-actin polymerization around the cell periphery, thereby maintaining proper cell shape during phagocytosis and chemotaxis. (977 aa)
rhebGTP-binding protein Rheb homolog; Binds GTP and exhibits intrinsic GTPase activity. Belongs to the small GTPase superfamily. Rheb family. (185 aa)
abpE-1Drebrin-like protein; Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G- actin. Controls pseudopodium number and motility in early stages of chemotactic aggregation. (481 aa)
sarAGTP-binding protein Sar1A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (188 aa)
DDB0190759Uncharacterized protein. (1079 aa)
ripARas-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa)
myoKMyosin-K heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (858 aa)
racHRho-related protein racH. (200 aa)
cshACitrate synthase, peroxisomal; Peroxisomal protein involved in the cellular biosynthesis of citrate, and required primarily for cell growth and modulation of multicellular development. (492 aa)
paxBPaxillin-B; Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB. (569 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
rab8ARas-related protein Rab-8A; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (208 aa)
rab8BRas-related protein Rab-8B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
ndkC-1Nucleoside diphosphate kinase, cytosolic; Major role in the synthesis of nucleoside triphosphates other than ATP; Belongs to the NDK family. (155 aa)
proAProfilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (126 aa)
proBProfilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (124 aa)
pkgBProtein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
rasBRas-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (197 aa)
rasSRas-like protein rasS; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (194 aa)
gpaDGuanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa)
pkaCcAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa)
rab21Ras-related protein Rab-21; Involved in the regulation of phagocytosis. (212 aa)
gpbAGuanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
rab2ARas-related protein Rab-2A. (207 aa)
rab14Ras-related protein Rab-14; Regulates the fusion of phagosomes and lysosomes. Belongs to the small GTPase superfamily. Rab family. (206 aa)
rab7ARas-related protein Rab-7A; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
plc1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (801 aa)
rabZRas-related protein RabZ. (229 aa)
DDB_G0294557Uncharacterized protein. (489 aa)
forGFormin-G; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1074 aa)
fcsBFatty acyl-CoA synthetase B; Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process; Belongs to the ATP-dependent AMP-binding enzyme family. (673 aa)
DDB_G0293920Uncharacterized protein. (861 aa)
DDB_G0292878WAS protein family homolog DDB_G0292878; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. (472 aa)
lst8Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
phgADrainin; May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body. (438 aa)
piaAProtein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa)
gefBRas guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa)
p2xAP2X receptor A; P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides. Inward currents evoked by intracellular ATP and ATP analogs. Exclusively selective for ATP over other nucleotides. Insensitive to P2 receptor antagonists PPADS, suramin and 2',3'-O-(2,4,6-trinitrophenyl)-ATP but inhibited by nanomolar concentrations of copper and sodium ion. More permeable to ammonium than either sodium or potassium ions and less permeable to choline. It has been reported that p2xA is not es [...] (378 aa)
lvsBBEACH domain-containing protein lvsB; Involved in negative regulation of lysosome biogenesis, by limiting the heterotypic fusion of early endosomes and postlysosomal compartments. (4118 aa)
limFLIM domain-containing protein F; Involved in the regulation of phagocytosis. May repress ChLim and activate rab21. (197 aa)
rpkARpkA. (828 aa)
pakBSerine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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