STRINGSTRING
csbB csbB rab8B rab8B tgrC1 tgrC1 dscE dscE cap cap cadA cadA lrrA lrrA triA triA frmA frmA gnt2 gnt2 cln3 cln3 talB talB cad3 cad3 DDB0220008 DDB0220008 tgrB1 tgrB1 DDB0206453 DDB0206453 ifkB ifkB gnt15 gnt15 cf50-1 cf50-1 ifkA ifkA DDB_G0271806 DDB_G0271806 DD7-1-2 DD7-1-2 psaA psaA DD7-1 DD7-1 DDB_G0276051 DDB_G0276051 htt htt napA napA DDB0167850 DDB0167850 cf45-1 cf45-1 paxB paxB ctnB ctnB racF2 racF2 dymB dymB abpD abpD dtfA dtfA cad2 cad2 dscA-1 dscA-1 dscC-1 dscC-1 dscD-1 dscD-1 ampA ampA csaA csaA frmC frmC talA talA pspA pspA csbA csbA rab8A rab8A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
csbBGlycoprotein 24B; Cell-cell adhesion during early development; Belongs to the csb family. (103 aa)
rab8BRas-related protein Rab-8B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
tgrC1Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1. (889 aa)
dscEDiscoidin-2; Galactose-binding lectin. May be necessary for the primary process of spore formation and may be involved in spore coat formation. (257 aa)
capAdenylyl cyclase-associated protein; May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner. (464 aa)
cadACalcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development. (213 aa)
lrrALeucine-rich repeat protein lrrA; Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis. (510 aa)
triATrishanku; Required for normal morphogenesis and cell-type stability. (697 aa)
frmAFERM domain-containing protein A; Key regulator of adhesion dynamics, it acts as an anti- adhesive. Plays a critical role in the regulation of cell-cell adhesion, multi-cellular development and, in particular, the formation of the organising center known as the tip. Required for turnover of paxillin-adhesion sites during cell migration. Plays a major role in normal cell shape, cell-substrate adhesion and actin cytoskeleton organization. (1154 aa)
gnt2GlcNAc transferase. (403 aa)
cln3Battenin. (421 aa)
talBTalin-B; Actin-binding protein required for multicellular morphogenesis. Substrate of pkgB and/or pkbA. (2614 aa)
cad3Putative calcium-dependent cell adhesion molecule 3; Mediates calcium-dependent cell-cell adhesion during the early stage of development; Belongs to the Dictyostelium CAD family. (213 aa)
DDB0220008SAP DNA-binding domain-containing protein. (1216 aa)
tgrB1Tiger protein B1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. (902 aa)
DDB0206453H_lectin domain-containing protein. (121 aa)
ifkBProbable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1358 aa)
gnt15Glycosyltransferase-like protein gnt15; May have a role in modulating cell adhesion and glycosylation. Essential for development. Belongs to the glycosyltransferase 8 family. Highly divergent. (516 aa)
cf50-1Counting factor 50; Cell-counting factor that limits the maximum size of the multicellular structure during aggregation. Has a very low lysozyme activity. (303 aa)
ifkAProbable serine/threonine-protein kinase ifkA; Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA. (2258 aa)
DDB_G0271806PH and Rap-GAP domain-containing protein DDB_G0271806. (1167 aa)
DD7-1-2F5/8 type C domain-containing protein. (262 aa)
psaAAminopeptidase. (861 aa)
DD7-1F5/8 type C domain-containing protein. (262 aa)
DDB_G0276051H_lectin domain-containing protein. (353 aa)
httHD protein homolog; May play a role in microtubule-mediated transport or vesicle function; Belongs to the huntingtin family. (3095 aa)
napANck-associated protein 1 homolog; Involved in regulation of actin and microtubule organization. Involved in cell adhesion. (1160 aa)
DDB0167850F5/8 type C domain-containing protein. (285 aa)
cf45-1Counting factor 45-1; Cell-counting factor that limits the maximum size of the multicellular structure during aggregation. (297 aa)
paxBPaxillin-B; Required for cell-substrate adhesion, cell sorting, slug migration, and cell differentiation. May function upstream of limB. (569 aa)
ctnBCountin-2; Cell-counting factor that limits the minimum size of the multicellular structure. May up-regulate the expression of both gp24 and gp80, which mediate cell adhesion. (254 aa)
racF2Rho-related protein racF2. (193 aa)
dymBDynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa)
abpDInteraptin; May function as linker between cellular membranes and the actin cytoskeleton. Required for normal development of fruiting bodies. (1738 aa)
dtfADefective in tip formation protein A; Required for correct organization of the actin cytoskeleton and cytokinesis. Also required for apical sorting of prestalk cells, a prerequisite for formation of the tip at the mound stage and subsequent formation of the fruiting body. May be required for cell adhesion. (1402 aa)
cad2Putative calcium-dependent cell adhesion molecule 2; Mediates calcium-dependent cell-cell adhesion during the early stage of development. (201 aa)
dscA-1Discoidin-1 subunit A; Galactose- and N-acetylgalactosamine-binding lectin. May play a role in cell-substratum adhesion rather than in cell-cell adhesion. May be necessary for the maintenance of normal elongate morphology during aggregation. (253 aa)
dscC-1Discoidin-1 subunit B/C; Galactose- and N-acetylgalactosamine-binding lectin. May play a role in cell-substratum adhesion rather than in cell-cell adhesion. May be necessary for the maintenance of normal elongate morphology during aggregation. (253 aa)
dscD-1Discoidin-1 subunit D; Galactose- and N-acetylgalactosamine-binding lectin. May play a role in cell-substratum adhesion rather than in cell-cell adhesion. May be necessary for the maintenance of normal elongate morphology during aggregation. (253 aa)
ampAPrestalk D11 protein. (284 aa)
csaAContact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction. (514 aa)
frmCFERM domain-containing protein C. (1489 aa)
talATalin-A; Actin-binding protein that may be involved in the control of cell motility and chemotaxis. (1279 aa)
pspAPrespore-specific protein A; May bind F-actin and nucleates actin assembly. Belongs to the ponticulin family. (168 aa)
csbAGlycoprotein 24A; Cell-cell adhesion during early development; Belongs to the csb family. (102 aa)
rab8ARas-related protein Rab-8A; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (208 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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