STRINGSTRING
rab8A rab8A rabN2 rabN2 rabP rabP vatM vatM DDB_G0292878 DDB_G0292878 vps35 vps35 DDB_G0293786 DDB_G0293786 DDB_G0290827 DDB_G0290827 rabK3 rabK3 DDB_G0294571 DDB_G0294571 rabK2 rabK2 rab11A rab11A rab7A rab7A rab1A rab1A corA corA rab8B rab8B rabN1 rabN1 rapA rapA arcD arcD vacA vacA arfA arfA lmpA lmpA amtA amtA Dd5P4 Dd5P4 rab5A rab5A Vps5 Vps5 chmp4 chmp4 atg8 atg8 vps26 vps26 cnxA cnxA rab11C rab11C rsmC rsmC DDB_0206311 DDB_0206311 DDB_G0282067 DDB_G0282067 DDB_G0283629 DDB_G0283629 vps4 vps4 tsg101 tsg101 rab11B rab11B ranbp1 ranbp1 rabO rabO rabM rabM rabL rabL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rab8ARas-related protein Rab-8A; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (208 aa)
rabN2Ras-related protein RabN2; Belongs to the small GTPase superfamily. Rab family. (184 aa)
rabPRas-related protein RabP. (232 aa)
vatMVacuolar proton translocating ATPase 100 kDa subunit; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Required in both the contractile vacuole system and the endosomal/lysosomal system. Also required for cytosolic pH regulation. Belongs to the V-ATPase 116 kDa subunit family. (815 aa)
DDB_G0292878WAS protein family homolog DDB_G0292878; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. (472 aa)
vps35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (781 aa)
DDB_G0293786Ras GTPase. (277 aa)
DDB_G0290827Rab GTPase domain-containing protein. (250 aa)
rabK3Ras-related protein RabK3; Belongs to the small GTPase superfamily. Rab family. (148 aa)
DDB_G0294571Rab GTPase. (203 aa)
rabK2Ras-related protein RabK2. (147 aa)
rab11ARas-related protein Rab-11A; Required for normal contractile vacuole structure and function. Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders. These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles. Belongs to the small GTPase superfamily. Rab family. (214 aa)
rab7ARas-related protein Rab-7A; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
rab1ARas-related protein Rab-1A. (202 aa)
corACoronin-A; Required for normal motility. Participates in cytokinesis. (445 aa)
rab8BRas-related protein Rab-8B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
rabN1Ras-related protein RabN1. (216 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
arcDActin-related protein 2/3 complex subunit 4; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (169 aa)
vacAVacuolin-A; Belongs to the vacuolin family. (598 aa)
arfAADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. (182 aa)
lmpALysosome membrane protein 2-A; May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis. Binds to the anionic phospholipid phosphoinositol 4,5-bisphosphate, but not to phosphatidylcholine and only weakly to phosphatidylserine. Belongs to the CD36 family. (779 aa)
amtAAmmonium transporter 1; Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (463 aa)
Dd5P4Inositol 5-phosphatase 4. (787 aa)
rab5ARas-related protein Rab-5A; Required for the fusion of plasma membranes and early endosomes. (201 aa)
Vps5PX domain-containing protein. (545 aa)
chmp4Charged multivesicular body protein 4; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins. (215 aa)
atg8Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family. (122 aa)
vps26Vacuolar protein sorting-associated protein 26; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (349 aa)
cnxAUncharacterized protein. (536 aa)
rab11CRas-related protein Rab-11C. (224 aa)
rsmCSmall GTPase. (240 aa)
DDB_0206311Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (894 aa)
DDB_G0282067Probable zinc transporter protein DDB_G0282067; May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces. (573 aa)
DDB_G0283629Probable zinc transporter protein DDB_G0283629; May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (543 aa)
vps4Vacuolar protein sorting-associated protein 4; Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity); Belongs to the AAA ATPase family. (444 aa)
tsg101ESCRT-I complex subunit tsg101; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Acts as a negative growth regulator (By similarity); Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. (478 aa)
rab11BRas-related protein Rab-11B. (220 aa)
ranbp1Ran-specific GTPase-activating protein homolog; Belongs to the RANBP1 family. (194 aa)
rabORas-related protein RabO. (218 aa)
rabMRas-related protein RabM. (202 aa)
rabLRas-related protein RabL. (204 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.