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rab5A rab5A vacA vacA ctsD ctsD act3 act3 act1 act1 mhcA mhcA dhcA dhcA manA manA rab7A rab7A vatD-1 vatD-1 dicA dicA myoE myoE rabK2 rabK2 DDB_G0294571 DDB_G0294571 rabK3 rabK3 DDB_G0290827 DDB_G0290827 DDB_G0275795 DDB_G0275795 DDB_G0292878 DDB_G0292878 vatM vatM rabP rabP rabN2 rabN2 rabN1 rabN1 rabL rabL rabM rabM rabO rabO act10 act10 vps29 vps29 DDB0204848 DDB0204848 DDB0205282 DDB0205282 vacB vacB vacC vacC act22 act22 phg1a phg1a Vps5 Vps5 lmpB lmpB racG racG myoK myoK lmpA lmpA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
rab5ARas-related protein Rab-5A; Required for the fusion of plasma membranes and early endosomes. (201 aa)
vacAVacuolin-A; Belongs to the vacuolin family. (598 aa)
ctsDCathepsin D; Protease that may act during cell growth and/or development; Belongs to the peptidase A1 family. (383 aa)
act3Actin-3; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction; Belongs to the actin family. (376 aa)
act1Major actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (376 aa)
mhcAMyosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
dhcADynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Belongs to the dynein heavy chain family. (4730 aa)
manAAlpha-mannosidase 58 kDa subunit. (1010 aa)
rab7ARas-related protein Rab-7A; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa)
vatD-1V-type proton ATPase subunit d; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase V0D/AC39 subunit family. (356 aa)
dicACytoplasmic dynein 1 intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chain mediates the binding of dynein to dynactin. (654 aa)
myoEMyosin IE heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. May play a role in moving membranes relative to actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1005 aa)
rabK2Ras-related protein RabK2. (147 aa)
DDB_G0294571Rab GTPase. (203 aa)
rabK3Ras-related protein RabK3; Belongs to the small GTPase superfamily. Rab family. (148 aa)
DDB_G0290827Rab GTPase domain-containing protein. (250 aa)
DDB_G0275795PH domain-containing protein DDB_G0275795. (808 aa)
DDB_G0292878WAS protein family homolog DDB_G0292878; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. (472 aa)
vatMVacuolar proton translocating ATPase 100 kDa subunit; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Required in both the contractile vacuole system and the endosomal/lysosomal system. Also required for cytosolic pH regulation. Belongs to the V-ATPase 116 kDa subunit family. (815 aa)
rabPRas-related protein RabP. (232 aa)
rabN2Ras-related protein RabN2; Belongs to the small GTPase superfamily. Rab family. (184 aa)
rabN1Ras-related protein RabN1. (216 aa)
rabLRas-related protein RabL. (204 aa)
rabMRas-related protein RabM. (202 aa)
rabORas-related protein RabO. (218 aa)
act10Actin-10; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa)
vps29Vacuolar protein sorting-associated protein 29; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (183 aa)
DDB0204848Rab-GAP TBC domain-containing protein. (1194 aa)
DDB0205282Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (568 aa)
vacBVacuolin-B; Negative regulator of late steps of the endocytic pathway. (592 aa)
vacCVacuolin-C; Belongs to the vacuolin family. (586 aa)
act22Putative actin-22; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa)
phg1aPutative phagocytic receptor 1a; Involved in adhesion, phagocytosis of hydrophilic particles and intracellular killing of bacteria. Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (641 aa)
Vps5PX domain-containing protein. (545 aa)
lmpBLysosome membrane protein 2-B; May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis; Belongs to the CD36 family. (755 aa)
racGRho-related protein racG. (201 aa)
myoKMyosin-K heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (858 aa)
lmpALysosome membrane protein 2-A; May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis. Binds to the anionic phospholipid phosphoinositol 4,5-bisphosphate, but not to phosphatidylcholine and only weakly to phosphatidylserine. Belongs to the CD36 family. (779 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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