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| | DDB_G0275795 | PH domain-containing protein DDB_G0275795. (808 aa) |
| | ctsD | Cathepsin D; Protease that may act during cell growth and/or development; Belongs to the peptidase A1 family. (383 aa) |
| | arcA | Actin-related protein 2/3 complex subunit 1; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general [...] (369 aa) |
| | act3 | Actin-3; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction; Belongs to the actin family. (376 aa) |
| | act1 | Major actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (376 aa) |
| | mhcA | Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa) |
| | dhcA | Dynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Belongs to the dynein heavy chain family. (4730 aa) |
| | myoB | Myosin IB heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myos [...] (1111 aa) |
| | manA | Alpha-mannosidase 58 kDa subunit. (1010 aa) |
| | rab14 | Ras-related protein Rab-14; Regulates the fusion of phagosomes and lysosomes. Belongs to the small GTPase superfamily. Rab family. (206 aa) |
| | rab7A | Ras-related protein Rab-7A; Key regulator in endo-lysosomal trafficking. Governs early- to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades (By similarity). Involved in lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity); Belongs to the small GTPase superfamily. Rab family. (203 aa) |
| | DDB_G0267684 | Uncharacterized protein. (764 aa) |
| | vatM | Vacuolar proton translocating ATPase 100 kDa subunit; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. Required in both the contractile vacuole system and the endosomal/lysosomal system. Also required for cytosolic pH regulation. Belongs to the V-ATPase 116 kDa subunit family. (815 aa) |
| | DDB_G0292878 | WAS protein family homolog DDB_G0292878; Acts as a nucleation-promoting factor by activating the Arp2/3 complex to induce actin polymerization. (472 aa) |
| | vti1A | Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Belongs to the VTI1 family. (217 aa) |
| | arpC | Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. The Arp2/3 complex is involved in organizing the actin system in cell motility and chemotaxis, in phagocytosis and macropinocytosis, at late steps of endosome processing, and in mitosis. In concert with a group of other proteins, the Arp2/3 complex plays a general role in [...] (418 aa) |
| | vatD-1 | V-type proton ATPase subunit d; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system; Belongs to the V-ATPase V0D/AC39 subunit family. (356 aa) |
| | vatA | V-type proton ATPase catalytic subunit A; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (618 aa) |
| | cap | Adenylyl cyclase-associated protein; May have a regulatory bifunctional role. Binds G-actin and PIP2. Involved in microfilament reorganization near the plasma membrane in a PIP2-regulated manner. (464 aa) |
| | rabO | Ras-related protein RabO. (218 aa) |
| | rabM | Ras-related protein RabM. (202 aa) |
| | rabL | Ras-related protein RabL. (204 aa) |
| | rabN1 | Ras-related protein RabN1. (216 aa) |
| | rabK1 | Ras-related protein RabK1; Belongs to the small GTPase superfamily. Rab family. (213 aa) |
| | rabN2 | Ras-related protein RabN2; Belongs to the small GTPase superfamily. Rab family. (184 aa) |
| | adcA | Arrestin domain-containing protein A. (580 aa) |
| | rabP | Ras-related protein RabP. (232 aa) |
| | fimA | Fimbrin; Binds to actin. (610 aa) |
| | dicA | Cytoplasmic dynein 1 intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chain mediates the binding of dynein to dynactin. (654 aa) |
| | comA | Comitin; May have a role in cell motility. It has high affinity for both G-actin and F-actin. Binds to vesicle membranes via mannose residues and, by way of its interaction with actin, links these membranes to the cytoskeleton. (185 aa) |
| | myoE | Myosin IE heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. May play a role in moving membranes relative to actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1005 aa) |
| | rabK2 | Ras-related protein RabK2. (147 aa) |
| | DDB_G0294571 | Rab GTPase. (203 aa) |
| | rabK3 | Ras-related protein RabK3; Belongs to the small GTPase superfamily. Rab family. (148 aa) |
| | DDB_G0290827 | Rab GTPase domain-containing protein. (250 aa) |
| | DDB0183788 | PKD_channel domain-containing protein. (823 aa) |
| | lmpA | Lysosome membrane protein 2-A; May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis. Binds to the anionic phospholipid phosphoinositol 4,5-bisphosphate, but not to phosphatidylcholine and only weakly to phosphatidylserine. Belongs to the CD36 family. (779 aa) |
| | myoK | Myosin-K heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (858 aa) |
| | dymB | Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa) |
| | wasA | Wiscott-Aldrich syndrome protein. (399 aa) |
| | racG | Rho-related protein racG. (201 aa) |
| | amtA | Ammonium transporter 1; Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (463 aa) |
| | amtB | Ammonium transporter 2; Ammonium transporter that mediates the excretion of ammonium from the prestalk cells from the slug. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. (431 aa) |
| | lmpB | Lysosome membrane protein 2-B; May act as a lysosomal receptor (By similarity). May be involved in macropinocytosis and fluid phase exocytosis; Belongs to the CD36 family. (755 aa) |
| | carmil | Protein CARMIL; Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellul [...] (1050 aa) |
| | gp130 | Lipid-anchored plasma membrane glycoprotein 130. (768 aa) |
| | dymA | Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway. (853 aa) |
| | amtC | Ammonium transporter 3; Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression. (431 aa) |
| | rab5A | Ras-related protein Rab-5A; Required for the fusion of plasma membranes and early endosomes. (201 aa) |
| | lvsB | BEACH domain-containing protein lvsB; Involved in negative regulation of lysosome biogenesis, by limiting the heterotypic fusion of early endosomes and postlysosomal compartments. (4118 aa) |
| | Vps5 | PX domain-containing protein. (545 aa) |
| | chmp4 | Charged multivesicular body protein 4; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins. (215 aa) |
| | nramp1 | Metal transporter nramp1 homolog; Depletes iron from the phagolysosome in an ATP-dependent process. May rather act as a symporter of protons and metal cations in an ATP-dependent process. Nramp1 overexpression protected cells from L.pneumophila infection. (533 aa) |
| | cpnA | Copine-A; Required for cytokinesis, contractile vacuole function and development; Belongs to the copine family. (600 aa) |
| | vatB | V-type proton ATPase subunit B; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. The B subunit is non- catalytic but combines with other subunits to form the catalytic complex. V-ATPase is responsible for energizing electrophoretic K(+)/2H(+) antiport by generating a transmembrane voltage of more than 200 mV (By similarity). (493 aa) |
| | ChLim | Calponin homology and LIM domain-containing protein; Involved in the regulation of phagocytosis. May repress rab21. (686 aa) |
| | lmpC | Lysosome membrane protein 2-C; May act as a lysosomal receptor (By similarity). May be involved role in macropinocytosis and fluid phase exocytosis. Belongs to the CD36 family. (782 aa) |
| | phg1a | Putative phagocytic receptor 1a; Involved in adhesion, phagocytosis of hydrophilic particles and intracellular killing of bacteria. Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface. Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (641 aa) |
| | DDB0190517 | Uncharacterized protein. (755 aa) |
| | DDB0216948 | Uncharacterized protein. (736 aa) |
| | abpE-1 | Drebrin-like protein; Actin-binding adapter protein. Binds to F-actin but is not involved in actin polymerization, capping or bundling. Does not bind G- actin. Controls pseudopodium number and motility in early stages of chemotactic aggregation. (481 aa) |
| | act22 | Putative actin-22; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa) |
| | DDB0217791 | Uncharacterized protein. (843 aa) |
| | DDB0218156 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1158 aa) |
| | vacC | Vacuolin-C; Belongs to the vacuolin family. (586 aa) |
| | vacB | Vacuolin-B; Negative regulator of late steps of the endocytic pathway. (592 aa) |
| | Cmr | Bulb-type lectin domain-containing protein. (135 aa) |
| | DDB0218302 | Uncharacterized protein. (753 aa) |
| | drkC | Probable serine/threonine-protein kinase drkC. (749 aa) |
| | DDB_G0282067 | Probable zinc transporter protein DDB_G0282067; May be involved in zinc transport from the cytoplasm to either intracellular organelles or extracellular spaces. (573 aa) |
| | DDB0205282 | Uncharacterized protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (568 aa) |
| | DDB0204848 | Rab-GAP TBC domain-containing protein. (1194 aa) |
| | DDB0185548 | Uncharacterized protein. (582 aa) |
| | DDB0185820 | Uncharacterized protein. (880 aa) |
| | Dd5P2 | Inositol 5-phosphatase. (1800 aa) |
| | DDB0186223 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1186 aa) |
| | vamp7A | Vesicle-associated membrane protein 7A; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis; Belongs to the synaptobrevin family. (216 aa) |
| | DDB0186277 | Uncharacterized protein. (1533 aa) |
| | DDB0187295 | ATP-synt_ab domain-containing protein. (94 aa) |
| | rab7B | Ras-related protein Rab-7B; Protein transport. Probably involved in vesicular traffic (By similarity). (197 aa) |
| | vps29 | Vacuolar protein sorting-associated protein 29; Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to- Golgi retrograde transport. The vps29-vps26-vps35 subcomplex may be involved in cargo selection. (183 aa) |
| | act10 | Actin-10; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction (By similarity); Belongs to the actin family. (376 aa) |
| | DDB_G0295801 | B_lectin domain-containing protein. (135 aa) |
| | vacA | Vacuolin-A; Belongs to the vacuolin family. (598 aa) |
