(33 nodes) Side of membrane network (Dictyostelium discoideum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tgrJ1	IPT/TIG domain-containing protein. (885 aa)
	DDB0231493	Peptidase A22B family protein. (354 aa)
	DDB0187507	Uncharacterized protein. (171 aa)
	tgrC1	Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1. (889 aa)
	gpbA	Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
	rasB	Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (197 aa)
	gpaA	Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa)
	gpaB	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa)
	rasG	Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
	pspA	Prespore-specific protein A; May bind F-actin and nucleates actin assembly. Belongs to the ponticulin family. (168 aa)
	csaA	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction. (514 aa)
	DDB_G0287521	Uncharacterized protein. (257 aa)
	5NT	Uncharacterized protein. (578 aa)
	cad3	Putative calcium-dependent cell adhesion molecule 3; Mediates calcium-dependent cell-cell adhesion during the early stage of development; Belongs to the Dictyostelium CAD family. (213 aa)
	cadA	Calcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development. (213 aa)
	tgrE1	Tiger protein E1. (912 aa)
	DDB0185939	BSD domain-containing protein. (482 aa)
	dnajc19	Mitochondrial import inner membrane translocase subunit TIM14; Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). (113 aa)
	DDB0205121	Uncharacterized protein. (464 aa)
	rsmB	Small GTPase. (260 aa)
	dhkA	Hybrid signal transduction histidine kinase A; Acts as a receptor histidine kinase for the cytokinin SDF-2 in a signal transduction pathway that regulates prestalk gene expression and controls terminal differentiation of prespore cells. Binding of SDF-2 to this protein inhibits phosphorelay and induces rapid sporulation. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain. (2150 aa)
	DDB0218292	Uncharacterized protein. (537 aa)
	tgrB1	Tiger protein B1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. (902 aa)
	DDB_G0280437	Ras GTPase. (298 aa)
	DDB0206405	Uncharacterized protein. (868 aa)
	DDB0205874	Glyco_hydro_63 domain-containing protein. (880 aa)
	DDB0205680	RRM_2 domain-containing protein. (1698 aa)
	DDB0217909	Uncharacterized protein. (1118 aa)
	DDB0217746	Uncharacterized protein. (1984 aa)
	DDB0220680	SAP DNA-binding domain-containing protein. (943 aa)
	nfaA	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB. (920 aa)
	fcsA	Fatty acyl-CoA synthetase A; Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm. Belongs to the ATP-dependent AMP-binding enzyme family. (667 aa)
	gpgA	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). Required for normal chemotaxis in response to cAMP. (69 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB_G0280437	nfaA	Q54VD5	Q55AR6	Ras GTPase.	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	0.622
DDB_G0280437	rasB	Q54VD5	P32252	Ras GTPase.	Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.	0.421
DDB_G0280437	rasG	Q54VD5	P15064	Ras GTPase.	Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.421
DDB_G0280437	rsmB	Q54VD5	Q54U62	Ras GTPase.	Small GTPase.	0.460
cadA	csaA	P54657	P08796	Calcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development.	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.	0.759
cadA	tgrC1	P54657	P42523	Calcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development.	Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1.	0.709
csaA	cadA	P08796	P54657	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.	Calcium-dependent cell adhesion molecule 1; Mediates calcium-dependent cell-cell adhesion during the early stage of development.	0.759
csaA	gpaB	P08796	P16051	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	0.404
csaA	tgrB1	P08796	Q54V07	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.	Tiger protein B1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development.	0.668
csaA	tgrC1	P08796	P42523	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.	Tiger protein C1; tgrB1 and tgrC1 are involved in kin discrimination. They play an essential role in aggregation and subsequent development. Could function as a non-diffusible cell-cell signaling molecule that is required for multicellular development. Has both cell-autonomous and non-cell-autonomous functions. Terminal node, epistatic both to comC and tgrD1. Activates tgrD1.	0.795
gpaA	gpaB	P16894	P16051	Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	0.577
gpaA	gpbA	P16894	P36408	Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.	Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.	0.852
gpaA	gpgA	P16894	Q95ZG8	Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). Required for normal chemotaxis in response to cAMP.	0.540
gpaB	csaA	P16051	P08796	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	Contact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction.	0.404
gpaB	gpaA	P16051	P16894	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.	0.577
gpaB	gpbA	P16051	P36408	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.	0.931
gpaB	gpgA	P16051	Q95ZG8	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. This major G-protein of the squid photoreceptor is involved in visual transduction. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). Required for normal chemotaxis in response to cAMP.	0.781
gpaB	rasG	P16051	P15064	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.530
gpbA	gpaA	P36408	P16894	Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.	Guanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family.	0.852
gpbA	gpaB	P36408	P16051	Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.	Guanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family.	0.931