(26 nodes) IQ motif, EF-hand binding site network (Dictyostelium discoideum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GxcT	Uncharacterized protein. (1574 aa)
	GxcEE	DH domain-containing protein. (651 aa)
	GxcCC	Uncharacterized protein. (1145 aa)
	DDB0206221	Uncharacterized protein. (905 aa)
	gxcII	DH domain-containing protein. (874 aa)
	racgef1	Rac guanyl-nucleotide exchange factor. (1218 aa)
	gxcJJ	Rac guanine nucleotide exchange factor JJ; GTPase-activating protein. (1173 aa)
	GxcD	Uncharacterized protein. (1063 aa)
	myoG	Myosin-G heavy chain; Myosins are actin-based motor molecules with ATPase activity. (3446 aa)
	GxcBB	Uncharacterized protein. (1096 aa)
	myoM	Myosin-M heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in macropinocytosis and remodeling of actin cytoskeleton. (1737 aa)
	myoI	Myosin-I heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in the early steps of phagocytosis and adhesion. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2357 aa)
	kxcA	Kinase and exchange factor for Rac A. (1311 aa)
	GxcHH	Uncharacterized protein. (954 aa)
	GxcKK	Uncharacterized protein. (667 aa)
	DDB0192033	Uncharacterized protein. (792 aa)
	gxcDD	Guanine exchange factor for Rac 30; GTPase-activating protein for Rac involved in streaming and development. (1632 aa)
	GxcFF	DH domain-containing protein. (741 aa)
	gxcZ	RhoGEF domain-containing protein. (1028 aa)
	myoE	Myosin IE heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. May play a role in moving membranes relative to actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1005 aa)
	myoJ	Myosin-J heavy chain; Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states. (2245 aa)
	myoH	Myosin-H heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1771 aa)
	myoF	Myosin IF heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1071 aa)
	myoA	Myosin IA heavy chain; Actin-based motor protein, possibly involved in a wide range of motile processes, such as cell movement across a surface, and extension and retraction of pseudopodia or lamellipodia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (994 aa)
	mhcA	Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2116 aa)
	GxcAA	Uncharacterized protein. (1069 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GxcAA	GxcBB	Q54S15	Q86K95	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcAA	GxcCC	Q54S15	Q54XA7	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcAA	GxcD	Q54S15	Q55G27	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcAA	GxcEE	Q54S15	Q54UJ2	Uncharacterized protein.	DH domain-containing protein.	0.404
GxcAA	GxcFF	Q54S15	Q54P81	Uncharacterized protein.	DH domain-containing protein.	0.409
GxcAA	GxcHH	Q54S15	Q54G10	Uncharacterized protein.	Uncharacterized protein.	0.404
GxcAA	GxcKK	Q54S15	Q54BY9	Uncharacterized protein.	Uncharacterized protein.	0.421
GxcAA	GxcT	Q54S15	Q55DL8	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcAA	gxcDD	Q54S15	Q1ZXH8	Uncharacterized protein.	Guanine exchange factor for Rac 30; GTPase-activating protein for Rac involved in streaming and development.	0.400
GxcAA	gxcII	Q54S15	Q54XW8	Uncharacterized protein.	DH domain-containing protein.	0.404
GxcAA	gxcJJ	Q54S15	Q553D3	Uncharacterized protein.	Rac guanine nucleotide exchange factor JJ; GTPase-activating protein.	0.404
GxcAA	gxcZ	Q54S15	Q1ZX99	Uncharacterized protein.	RhoGEF domain-containing protein.	0.404
GxcAA	racgef1	Q54S15	Q54YZ6	Uncharacterized protein.	Rac guanyl-nucleotide exchange factor.	0.404
GxcBB	GxcAA	Q86K95	Q54S15	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcBB	GxcCC	Q86K95	Q54XA7	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcBB	GxcD	Q86K95	Q55G27	Uncharacterized protein.	Uncharacterized protein.	0.400
GxcBB	GxcEE	Q86K95	Q54UJ2	Uncharacterized protein.	DH domain-containing protein.	0.404
GxcBB	GxcFF	Q86K95	Q54P81	Uncharacterized protein.	DH domain-containing protein.	0.404
GxcBB	GxcHH	Q86K95	Q54G10	Uncharacterized protein.	Uncharacterized protein.	0.404
GxcBB	GxcKK	Q86K95	Q54BY9	Uncharacterized protein.	Uncharacterized protein.	0.421