(14 nodes) Ras GTPase-activating domain network (Dictyostelium discoideum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDB0219647	Uncharacterized protein. (1918 aa)
	DDB0188195	Ras-GAP domain-containing protein. (817 aa)
	gapA	Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa)
	rgaA	Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa)
	DDB0185880	Ras-GAP domain-containing protein. (1056 aa)
	DDB0185273	Ras-GAP domain-containing protein. (608 aa)
	DDB0205121	Uncharacterized protein. (464 aa)
	ngap	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein. (877 aa)
	DDB0202463	Uncharacterized protein. (1385 aa)
	nfaA	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB. (920 aa)
	DDB0190683	Uncharacterized protein. (2044 aa)
	DG1112	Developmental gene product DG1112. (1057 aa)
	DDB0169348	Ras-GAP domain-containing protein. (703 aa)
	DDB0167574	Ras-GAP domain-containing protein. (1728 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0167574	DDB0169348	Q8SSU4	Q86JJ7	Ras-GAP domain-containing protein.	Ras-GAP domain-containing protein.	0.400
DDB0167574	DDB0185880	Q8SSU4	Q54Q13	Ras-GAP domain-containing protein.	Ras-GAP domain-containing protein.	0.479
DDB0167574	nfaA	Q8SSU4	Q55AR6	Ras-GAP domain-containing protein.	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	0.406
DDB0167574	ngap	Q8SSU4	Q54Y08	Ras-GAP domain-containing protein.	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	0.422
DDB0169348	DDB0167574	Q86JJ7	Q8SSU4	Ras-GAP domain-containing protein.	Ras-GAP domain-containing protein.	0.400
DDB0169348	DDB0185880	Q86JJ7	Q54Q13	Ras-GAP domain-containing protein.	Ras-GAP domain-containing protein.	0.400
DDB0169348	nfaA	Q86JJ7	Q55AR6	Ras-GAP domain-containing protein.	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	0.501
DDB0169348	ngap	Q86JJ7	Q54Y08	Ras-GAP domain-containing protein.	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	0.400
DDB0185880	DDB0167574	Q54Q13	Q8SSU4	Ras-GAP domain-containing protein.	Ras-GAP domain-containing protein.	0.479
DDB0185880	DDB0169348	Q54Q13	Q86JJ7	Ras-GAP domain-containing protein.	Ras-GAP domain-containing protein.	0.400
DDB0185880	nfaA	Q54Q13	Q55AR6	Ras-GAP domain-containing protein.	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	0.479
DDB0185880	ngap	Q54Q13	Q54Y08	Ras-GAP domain-containing protein.	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	0.591
DDB0205121	ngap	Q54T13	Q54Y08	Uncharacterized protein.	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	0.416
gapA	rgaA	O00899	Q54K32	Ras GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell.	Ras GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...]	0.450
nfaA	DDB0167574	Q55AR6	Q8SSU4	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	Ras-GAP domain-containing protein.	0.406
nfaA	DDB0169348	Q55AR6	Q86JJ7	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	Ras-GAP domain-containing protein.	0.501
nfaA	DDB0185880	Q55AR6	Q54Q13	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	Ras-GAP domain-containing protein.	0.479
nfaA	ngap	Q55AR6	Q54Y08	Neurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB.	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	0.502
ngap	DDB0167574	Q54Y08	Q8SSU4	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	Ras-GAP domain-containing protein.	0.422
ngap	DDB0169348	Q54Y08	Q86JJ7	Probable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein.	Ras-GAP domain-containing protein.	0.400