STRINGSTRING
abcC5 abcC5 dhcA dhcA psmC4 psmC4 psmC5 psmC5 tagB tagB cdcD cdcD DDB_G0276169 DDB_G0276169 tagC tagC rfc3 rfc3 abcB2 abcB2 abcA3 abcA3 abcB1 abcB1 DDB_G0293388 DDB_G0293388 DDB0191825 DDB0191825 gpn1 gpn1 Rvb1 Rvb1 abcG10 abcG10 pex6 pex6 abcA9 abcA9 bcsl1b bcsl1b rfc2 rfc2 abcC7 abcC7 DDB0183816 DDB0183816 ascc3 ascc3 pex1 pex1 DDB0219440 DDB0219440 abcG16 abcG16 bcs1la bcs1la DDB0188234 DDB0188234 DDB0188012 DDB0188012 abcC3 abcC3 abcC14 abcC14 DDB_G0287165 DDB_G0287165 DDB0229898 DDB0229898 Mcm9 Mcm9 rfc4 rfc4 rfc1 rfc1 abcC9 abcC9 abcC8 abcC8 psmC6 psmC6 psmC3 psmC3 vps4 vps4 DDB0229917 DDB0229917 dhkG dhkG Xrcc3 Xrcc3 abcH4 abcH4 abcA10 abcA10 orcA orcA Mcm8 Mcm8 abcB6 abcB6 DDB_G0282241 DDB_G0282241 rfc5 rfc5 DDB_G0282215 DDB_G0282215 nvl nvl abcG24 abcG24 abcG6 abcG6 abcG5 abcG5 DDB0220704 DDB0220704 abcC12 abcC12 rvb2 rvb2 abcC13 abcC13 abcC15 abcC15 Mcm3 Mcm3 abcC2 abcC2 abcD1 abcD1 abcD3 abcD3 abcB4 abcB4 DDB0205041 DDB0205041 DDB0205453 DDB0205453 DDB_G0278063 DDB_G0278063 PIF1 PIF1 srpra srpra DDB_0217928 DDB_0217928 abcA11 abcA11 DDB0217538 DDB0217538 abcA4 abcA4 abcG17-1 abcG17-1 DDB0168161 DDB0168161 abcA8 abcA8 psmC1 psmC1 ascc3l ascc3l atp5f1b atp5f1b abcG22 abcG22 abcB7 abcB7 abcG11 abcG11 abcG14 abcG14 abcG1 abcG1 abcG23 abcG23 DDB_G0268662 DDB_G0268662 DDB_G0268924 DDB_G0268924 DDB0202221 DDB0202221 DDB0189755 DDB0189755 abcG15 abcG15 DDB0202133 DDB0202133 DDB_G0268504 DDB_G0268504 DDB0189322 DDB0189322 DDB0168508 DDB0168508 nsfA nsfA recA recA rcaA rcaA wrnip1 wrnip1 srp54 srp54 mdn1 mdn1 DDB0168975 DDB0168975 abcG8 abcG8 abcF3 abcF3 psmC2 psmC2 DDB_G0272758 DDB_G0272758 abcG18 abcG18 abcC10 abcC10 abcA1 abcA1 abcH2 abcH2 abcH.1 abcH.1 abcG21 abcG21 abcG20 abcG20 abcG19 abcG19 abcG9 abcG9 abcG12 abcG12 abcG7 abcG7 abcG4 abcG4 abcG3 abcG3 abcF4 abcF4 abcF2 abcF2 abcF1 abcF1 abcC6 abcC6 abcC1 abcC1 abcA7 abcA7 abcA6 abcA6 abcA5 abcA5 abcA2 abcA2 abcE1 abcE1 abcD2 abcD2 tagD tagD abcB5 abcB5 abcB3 abcB3 tagA tagA abcG2 abcG2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
abcC5ABC transporter C family member 5. (1460 aa)
dhcADynein heavy chain, cytoplasmic; Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP; Belongs to the dynein heavy chain family. (4730 aa)
psmC426S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
psmC526S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
tagBSerine protease/ABC transporter B family protein tagB; Intercellular communication via tagB may mediate integration of cellular differentiation with morphogenesis. In the N-terminal section; belongs to the peptidase S8 family. (1906 aa)
cdcDCell division cycle protein 48; Belongs to the AAA ATPase family. (793 aa)
DDB_G0276169AAA ATPase domain-containing protein; Belongs to the AAA ATPase family. (330 aa)
tagCSerine protease/ABC transporter B family protein tagC; May be directly involved in maturation and export of SDF-2. The exposure of the protease domain of tagC on the surface of the prestalk cells were it can convert acbA to SDF-2 is induced by GABA. Intercellular communication via tagC may mediate integration of cellular differentiation with morphogenesis. In the C-terminal section; belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. (1741 aa)
rfc3Probable replication factor C subunit 3; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (347 aa)
abcB2ABC transporter B family member 2. (1397 aa)
abcA3ABC transporter A family member 3. (1702 aa)
abcB1ABC transporter B family member 1. (909 aa)
DDB_G0293388ATP-dependent metalloprotease. (767 aa)
DDB0191825ATP-dependent DNA helicase; Belongs to the helicase family. (846 aa)
gpn1GPN-loop GTPase 1; Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. (396 aa)
Rvb1RuvB-like helicase; Belongs to the RuvB family. (523 aa)
abcG10ABC transporter G family member 10. (1466 aa)
pex6Peroxisomal biogenesis factor 6; Required for biogenesis of peroxisomes; Belongs to the AAA ATPase family. (1201 aa)
abcA9ABC transporter A family member 9. (845 aa)
bcsl1bProbable mitochondrial chaperone BCS1-B; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. (458 aa)
rfc2Probable replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (338 aa)
abcC7ABC transporter C family member 7. (1328 aa)
DDB0183816Uncharacterized protein; Belongs to the ClpA/ClpB family. (886 aa)
ascc3Activating signal cointegrator 1 complex subunit 3. (2195 aa)
pex1Peroxisome biogenesis factor 1; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family. (1227 aa)
DDB0219440AAA domain-containing protein. (1677 aa)
abcG16ABC transporter G family member 16. (1528 aa)
bcs1laProbable mitochondrial chaperone BCS1-A; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. (421 aa)
DDB0188234Uncharacterized protein; Belongs to the ClpA/ClpB family. (795 aa)
DDB0188012Uncharacterized protein. (694 aa)
abcC3ABC transporter C family member 3. (1412 aa)
abcC14ABC transporter C family member 14. (1317 aa)
DDB_G0287165Spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily. (655 aa)
DDB0229898AAA ATPase domain-containing protein. (574 aa)
Mcm9MCM domain-containing protein; Belongs to the MCM family. (1275 aa)
rfc4Probable replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (347 aa)
rfc1Probable replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 1 binds to the primer-template junction (By similarity). (1401 aa)
abcC9ABC transporter C family member 9. (1345 aa)
abcC8ABC transporter C family member 8. (1593 aa)
psmC626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (393 aa)
psmC326S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (421 aa)
vps4Vacuolar protein sorting-associated protein 4; Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity); Belongs to the AAA ATPase family. (444 aa)
DDB0229917AAA ATPase domain-containing protein. (764 aa)
dhkGHybrid signal transduction histidine kinase G; Acts as a receptor histidine kinase for a signal transduction pathway. This protein undergoes an ATP-dependent autophosphorylation at a conserved histidine residue in the kinase core, and a phosphoryl group is then transferred to a conserved aspartate residue in the receiver domain (By similarity). (3432 aa)
Xrcc3RECA_2 domain-containing protein. (564 aa)
abcH4ABC transporter H family member 4. (882 aa)
abcA10ABC transporter A family member 10. (887 aa)
orcAOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (631 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (812 aa)
abcB6ABC transporter B family member 6. (678 aa)
DDB_G0282241Uncharacterized protein. (825 aa)
rfc5Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (347 aa)
DDB_G0282215AAA ATPase domain-containing protein. (534 aa)
nvlPutative ribosome biogenesis ATPase nvl; Involved in ribosome biogenesis. Belongs to the AAA ATPase family. (867 aa)
abcG24ABC transporter G family member 24. (1159 aa)
abcG6ABC transporter G family member 6. (1534 aa)
abcG5ABC transporter G family member 5. (1509 aa)
DDB0220704Bromodomain-containing protein. (1800 aa)
abcC12ABC transporter C family member 12. (1323 aa)
rvb2RuvB-like helicase 2; Has double-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription. (469 aa)
abcC13ABC transporter C family member 13. (1350 aa)
abcC15ABC transporter C family member 15. (1436 aa)
Mcm3DNA helicase; Belongs to the MCM family. (867 aa)
abcC2ABC transporter C family member 2. (1384 aa)
abcD1ABC transporter D family member 1. (734 aa)
abcD3ABC transporter D family member 3. (750 aa)
abcB4ABC transporter B family member 4. (767 aa)
DDB0205041AAA domain-containing protein; Belongs to the AAA ATPase family. (373 aa)
DDB0205453Uncharacterized protein. (886 aa)
DDB_G0278063Lon protease homolog, mitochondrial 1; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. (956 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (669 aa)
srpraSignal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (By similarity). (615 aa)
DDB_0217928Lon protease homolog, mitochondrial 2; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. (836 aa)
abcA11ABC transporter A family member 11. (834 aa)
DDB0217538RECA_2 domain-containing protein; Belongs to the RecA family. (458 aa)
abcA4ABC transporter A family member 4. (1615 aa)
abcG17-1ABC transporter G family member 17. (1476 aa)
DDB0168161DNA repair protein RAD51 homolog; Binds to single and double-stranded DNA and exhibits DNA- dependent ATPase activity. Underwinds duplex DNA. Belongs to the RecA family. RAD51 subfamily. (351 aa)
abcA8ABC transporter A family member 8. (837 aa)
psmC126S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. (439 aa)
ascc3lActivating signal cointegrator 1 complex subunit 3-like; Belongs to the helicase family. (2237 aa)
atp5f1bATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...] (651 aa)
abcG22ABC transporter G family member 22; May be involved in cell migration. (615 aa)
abcB7ABC transporter B family member 7. (824 aa)
abcG11ABC transporter G family member 11. (1442 aa)
abcG14ABC transporter G family member 14. (1439 aa)
abcG1ABC transporter G family member 1. (793 aa)
abcG23ABC transporter G family member 23. (701 aa)
DDB_G0268662DNA2/NAM7 helicase family protein. (2523 aa)
DDB_G0268924AAA domain-containing protein. (1772 aa)
DDB0202221ATP-dependent DNA helicase; Belongs to the helicase family. (933 aa)
DDB0189755Uncharacterized protein. (864 aa)
abcG15ABC transporter G family member 15. (1475 aa)
DDB0202133AAA domain-containing protein; Belongs to the AAA ATPase family. (792 aa)
DDB_G0268504Uncharacterized protein. (5277 aa)
DDB0189322AAA domain-containing protein. (720 aa)
DDB0168508R3H domain-containing protein. (1024 aa)
nsfAVesicle-fusing ATPase; Required for vesicle-mediated transport. Involved in endocytosis and endosome-endosome fusion. May be required for transport from the endoplasmic reticulum to the Golgi stack, and for the fusion of transport vesicles within the Golgi cisternae. Required for cell polarity, locomotion and chemotaxis. (738 aa)
recAMitochondrial DNA repair protein recA homolog; Involved in DNA recombination ability. Important for survival following exposure to DNA damaging agents. Belongs to the RecA family. (452 aa)
rcaAAAA domain-containing protein. (844 aa)
wrnip1ATPase WRNIP1; Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity). (876 aa)
srp54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein); Belongs to the GTP-binding SRP family. SRP54 subfamily. (542 aa)
mdn1Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. (5900 aa)
DDB0168975Uncharacterized protein. (738 aa)
abcG8ABC transporter G family member 8. (626 aa)
abcF3Non-transporter ABC protein. (652 aa)
psmC226S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (428 aa)
DDB_G0272758AAA ATPase domain-containing protein. (937 aa)
abcG18ABC transporter G family member 18; Required for endocytosis and endosomal pH regulation. (1476 aa)
abcC10ABC transporter C family member 10. (1334 aa)
abcA1ABC transporter A family member 1. (877 aa)
abcH2ABC transporter H family member 2; Belongs to the ABC transporter superfamily. (513 aa)
abcH.1Putative non-transporter ABC protein. (266 aa)
abcG21ABC transporter G family member 21. (1449 aa)
abcG20ABC transporter G family member 20. (730 aa)
abcG19ABC transporter G family member 19. (1449 aa)
abcG9ABC transporter G family member 9. (1448 aa)
abcG12ABC transporter G family member 12. (638 aa)
abcG7ABC transporter G family member 7. (815 aa)
abcG4ABC transporter G family member 4. (798 aa)
abcG3ABC transporter G family member 3. (1393 aa)
abcF4ABC transporter F family member 4; Belongs to the ABC transporter superfamily. (1142 aa)
abcF2ABC transporter F family member 2; Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. (593 aa)
abcF1Non-transporter ABC protein AbcF1. (708 aa)
abcC6ABC transporter C family member 6. (1351 aa)
abcC1ABC transporter C family member 1. (1359 aa)
abcA7ABC transporter A family member 7. (839 aa)
abcA6ABC transporter A family member 6. (1631 aa)
abcA5ABC transporter A family member 5. (1662 aa)
abcA2ABC transporter A family member 2. (1621 aa)
abcE1RNaseL inhibitor-like protein ABCE.1. (603 aa)
abcD2ABC transporter D family member 2. (741 aa)
tagDSerine protease/ABC transporter B family protein tagD; In the N-terminal section; belongs to the peptidase S8 family. (1825 aa)
abcB5ABC transporter B family member 5. (697 aa)
abcB3ABC transporter B family member 3. (1432 aa)
tagASerine protease/ABC transporter B family protein tagA; Required for a general cell fate determination at the onset of development. Required for the specification of an initial population of prespore cells in which tagA is expressed. Required for normal SDF-2 signaling during spore encapsulation; In the N-terminal section; belongs to the peptidase S8 family. (1752 aa)
abcG2ABC transporter G family member 2; Required for endocytosis and endosomal pH regulation. Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily. (1328 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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