STRINGSTRING
psmC3 psmC3 DDB_G0272758 DDB_G0272758 psmC2 psmC2 DDB0168975 DDB0168975 orcD orcD wrnip1 wrnip1 rcaA rcaA nsfA nsfA DDB0189322 DDB0189322 DDB_G0268504 DDB_G0268504 DDB0202133 DDB0202133 DDB0189755 DDB0189755 psmC1 psmC1 DDB_0217928 DDB_0217928 DDB_G0278063 DDB_G0278063 DDB0205453 DDB0205453 DDB0205041 DDB0205041 DDB0220704 DDB0220704 nvl nvl DDB_G0282215 DDB_G0282215 rfc5 rfc5 DDB_G0282241 DDB_G0282241 orcA orcA DDB0229917 DDB0229917 vps4 vps4 psmC6 psmC6 DDB_G0284767 DDB_G0284767 rfc1 rfc1 rfc4 rfc4 DDB0229898 DDB0229898 DDB_G0287165 DDB_G0287165 DDB0188012 DDB0188012 DDB0188234 DDB0188234 bcs1la bcs1la pex1 pex1 DDB0183816 DDB0183816 rfc2 rfc2 bcsl1b bcsl1b pex6 pex6 DDB_G0293388 DDB_G0293388 DDB_G0276169 DDB_G0276169 cdcD cdcD psmC5 psmC5 psmC4 psmC4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
psmC326S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (421 aa)
DDB_G0272758AAA ATPase domain-containing protein. (937 aa)
psmC226S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (428 aa)
DDB0168975Uncharacterized protein. (738 aa)
orcDOrigin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (440 aa)
wrnip1ATPase WRNIP1; Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis (By similarity). (876 aa)
rcaAAAA domain-containing protein. (844 aa)
nsfAVesicle-fusing ATPase; Required for vesicle-mediated transport. Involved in endocytosis and endosome-endosome fusion. May be required for transport from the endoplasmic reticulum to the Golgi stack, and for the fusion of transport vesicles within the Golgi cisternae. Required for cell polarity, locomotion and chemotaxis. (738 aa)
DDB0189322AAA domain-containing protein. (720 aa)
DDB_G0268504Uncharacterized protein. (5277 aa)
DDB0202133AAA domain-containing protein; Belongs to the AAA ATPase family. (792 aa)
DDB0189755Uncharacterized protein. (864 aa)
psmC126S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. (439 aa)
DDB_0217928Lon protease homolog, mitochondrial 2; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. (836 aa)
DDB_G0278063Lon protease homolog, mitochondrial 1; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner. (956 aa)
DDB0205453Uncharacterized protein. (886 aa)
DDB0205041AAA domain-containing protein; Belongs to the AAA ATPase family. (373 aa)
DDB0220704Bromodomain-containing protein. (1800 aa)
nvlPutative ribosome biogenesis ATPase nvl; Involved in ribosome biogenesis. Belongs to the AAA ATPase family. (867 aa)
DDB_G0282215AAA ATPase domain-containing protein. (534 aa)
rfc5Probable replication factor C subunit 5; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (347 aa)
DDB_G0282241Uncharacterized protein. (825 aa)
orcAOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity). (631 aa)
DDB0229917AAA ATPase domain-containing protein. (764 aa)
vps4Vacuolar protein sorting-associated protein 4; Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity); Belongs to the AAA ATPase family. (444 aa)
psmC626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (393 aa)
DDB_G0284767Uncharacterized protein DDB_G0284767. (757 aa)
rfc1Probable replication factor C subunit 1; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 1 binds to the primer-template junction (By similarity). (1401 aa)
rfc4Probable replication factor C subunit 4; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit may be involved in the elongation of the multiprimed DNA template (By similarity). (347 aa)
DDB0229898AAA ATPase domain-containing protein. (574 aa)
DDB_G0287165Spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily. (655 aa)
DDB0188012Uncharacterized protein. (694 aa)
DDB0188234Uncharacterized protein; Belongs to the ClpA/ClpB family. (795 aa)
bcs1laProbable mitochondrial chaperone BCS1-A; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. (421 aa)
pex1Peroxisome biogenesis factor 1; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family. (1227 aa)
DDB0183816Uncharacterized protein; Belongs to the ClpA/ClpB family. (886 aa)
rfc2Probable replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. (338 aa)
bcsl1bProbable mitochondrial chaperone BCS1-B; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. (458 aa)
pex6Peroxisomal biogenesis factor 6; Required for biogenesis of peroxisomes; Belongs to the AAA ATPase family. (1201 aa)
DDB_G0293388ATP-dependent metalloprotease. (767 aa)
DDB_G0276169AAA ATPase domain-containing protein; Belongs to the AAA ATPase family. (330 aa)
cdcDCell division cycle protein 48; Belongs to the AAA ATPase family. (793 aa)
psmC526S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
psmC426S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.