25 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDB0189755	Uncharacterized protein. (864 aa)
	DDB0202133	AAA domain-containing protein; Belongs to the AAA ATPase family. (792 aa)
	DDB0189322	AAA domain-containing protein. (720 aa)
	nsfA	Vesicle-fusing ATPase; Required for vesicle-mediated transport. Involved in endocytosis and endosome-endosome fusion. May be required for transport from the endoplasmic reticulum to the Golgi stack, and for the fusion of transport vesicles within the Golgi cisternae. Required for cell polarity, locomotion and chemotaxis. (738 aa)
	rcaA	AAA domain-containing protein. (844 aa)
	DDB0168975	Uncharacterized protein. (738 aa)
	psmC2	26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (428 aa)
	psmC4	26S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
	psmC5	26S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
	cdcD	Cell division cycle protein 48; Belongs to the AAA ATPase family. (793 aa)
	DDB_G0276169	AAA ATPase domain-containing protein; Belongs to the AAA ATPase family. (330 aa)
	DDB_G0293388	ATP-dependent metalloprotease. (767 aa)
	pex6	Peroxisomal biogenesis factor 6; Required for biogenesis of peroxisomes; Belongs to the AAA ATPase family. (1201 aa)
	pex1	Peroxisome biogenesis factor 1; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family. (1227 aa)
	bcs1la	Probable mitochondrial chaperone BCS1-A; Chaperone necessary for the assembly of mitochondrial respiratory chain complex III; Belongs to the AAA ATPase family. BCS1 subfamily. (421 aa)
	DDB_G0287165	Spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily. (655 aa)
	psmC6	26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (393 aa)
	psmC3	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (421 aa)
	vps4	Vacuolar protein sorting-associated protein 4; Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity); Belongs to the AAA ATPase family. (444 aa)
	DDB0229917	AAA ATPase domain-containing protein. (764 aa)
	DDB_G0282241	Uncharacterized protein. (825 aa)
	DDB0220704	Bromodomain-containing protein. (1800 aa)
	DDB0205041	AAA domain-containing protein; Belongs to the AAA ATPase family. (373 aa)
	DDB0205453	Uncharacterized protein. (886 aa)
	psmC1	26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. (439 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0168975	cdcD	Q86B10	P90532	Uncharacterized protein.	Cell division cycle protein 48; Belongs to the AAA ATPase family.	0.913
DDB0168975	psmC1	Q86B10	Q55BV5	Uncharacterized protein.	26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development.	0.411
DDB0168975	psmC2	Q86B10	Q86JA1	Uncharacterized protein.	26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.407
DDB0168975	psmC3	Q86B10	Q54PN7	Uncharacterized protein.	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.508
DDB0168975	psmC5	Q86B10	P34124	Uncharacterized protein.	26S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.408
DDB0189755	psmC1	Q55FK3	Q55BV5	Uncharacterized protein.	26S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development.	0.402
DDB0189755	psmC2	Q55FK3	Q86JA1	Uncharacterized protein.	26S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.412
DDB0189755	psmC3	Q55FK3	Q54PN7	Uncharacterized protein.	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.501
DDB0189755	psmC5	Q55FK3	P34124	Uncharacterized protein.	26S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.423
DDB0205453	psmC3	Q54Y38	Q54PN7	Uncharacterized protein.	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.468
DDB0220704	psmC3	Q54TZ0	Q54PN7	Bromodomain-containing protein.	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.507
DDB0220704	psmC4	Q54TZ0	P34123	Bromodomain-containing protein.	26S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.498
DDB0220704	psmC6	Q54TZ0	Q54PJ1	Bromodomain-containing protein.	26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.509
DDB0229917	rcaA	Q54PX1	Q75JS8	AAA ATPase domain-containing protein.	AAA domain-containing protein.	0.572
DDB_G0276169	psmC6	Q1ZXK7	Q54PJ1	AAA ATPase domain-containing protein; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.408
DDB_G0282241	psmC3	Q54ST1	Q54PN7	Uncharacterized protein.	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.473
DDB_G0287165	vps4	Q54KQ7	Q54PT2	Spastin; ATP-dependent microtubule severing protein. Microtubule severing may promote reorganization of cellular microtubule arrays and the release of microtubules from the microtubule organizing center following nucleation; Belongs to the AAA ATPase family. Spastin subfamily.	Vacuolar protein sorting-associated protein 4; Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity); Belongs to the AAA ATPase family.	0.553
cdcD	DDB0168975	P90532	Q86B10	Cell division cycle protein 48; Belongs to the AAA ATPase family.	Uncharacterized protein.	0.913
cdcD	psmC3	P90532	Q54PN7	Cell division cycle protein 48; Belongs to the AAA ATPase family.	26S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).	0.465
pex1	pex6	Q54GX5	Q54CS8	Peroxisome biogenesis factor 1; Involved in peroxisome biosynthesis; Belongs to the AAA ATPase family.	Peroxisomal biogenesis factor 6; Required for biogenesis of peroxisomes; Belongs to the AAA ATPase family.	0.999