STRINGSTRING
gacM gacM gacFF gacFF gacH gacH gacHH gacHH gacB gacB gacR gacR gacP gacP gacN gacN GflD GflD gacGG gacGG gacY gacY DDB0205121 DDB0205121 gacQ gacQ DDB0185273 DDB0185273 mgp4 mgp4 gacG gacG DDB0185880 DDB0185880 gacC gacC gacT gacT XacC XacC DDB0167574 DDB0167574 gacF gacF gefD gefD Dd5P4 Dd5P4 DDB0169348 DDB0169348 mgp3 mgp3 gacZ gacZ roco7 roco7 gacO gacO roco10 roco10 roco9 roco9 DG1112 DG1112 GacS GacS gacD gacD DDB0219647 DDB0219647 gacEE gacEE racGAP racGAP DDB_G0293184 DDB_G0293184 gacV gacV gacE gacE DDB0215136 DDB0215136 gapA gapA gacL gacL gacJJ gacJJ gacW gacW mgp1 mgp1 DDB0188195 DDB0188195 gacX gacX rgaA rgaA gflB gflB gacK gacK gacJ gacJ ngap ngap XacB XacB gacA gacA gacII gacII DDB0202463 DDB0202463 gacI gacI gacU gacU nfaA nfaA mgp2 mgp2 DDB0190683 DDB0190683
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gacMRho GTPase-activating protein gacM; Rho GTPase-activating protein involved in the signal transduction pathway. (896 aa)
gacFFRho GTPase-activating protein gacFF; Rho GTPase-activating protein involved in the signal transduction pathway. (885 aa)
gacHRho GTPase-activating protein gacH; Rho GTPase-activating protein involved in the signal transduction pathway. (566 aa)
gacHHRho GTPase-activating protein gacHH; Rho GTPase-activating protein involved in the signal transduction pathway. (1523 aa)
gacBRho GTPase-activating protein gacB; Rho GTPase-activating protein involved in the signal transduction pathway. (273 aa)
gacRRho GTPase-activating protein gacR; Rho GTPase-activating protein involved in the signal transduction pathway. (783 aa)
gacPRho GTPase-activating protein gacP; Rho GTPase-activating protein involved in the signal transduction pathway. (576 aa)
gacNRho GTPase-activating protein gacN; Rho GTPase-activating protein involved in the signal transduction pathway. (611 aa)
GflDRas-GEF domain-containing protein. (1765 aa)
gacGGRho GTPase-activating protein gacGG; Rho GTPase-activating protein involved in the signal transduction pathway. (1203 aa)
gacYRho GTPase-activating protein gacY; Rho GTPase-activating protein involved in the signal transduction pathway. (721 aa)
DDB0205121Uncharacterized protein. (464 aa)
gacQRho GTPase-activating protein gacQ; Rho GTPase-activating protein involved in the signal transduction pathway. (531 aa)
DDB0185273Ras-GAP domain-containing protein. (608 aa)
mgp4Mental retardation GTPase activating protein homolog 4; Rho GTPase-activating protein involved in the signal transduction pathway. (909 aa)
gacGRho GTPase-activating protein gacG; Rho GTPase-activating protein involved in the signal transduction pathway. (1312 aa)
DDB0185880Ras-GAP domain-containing protein. (1056 aa)
gacCRho GTPase-activating protein gacC; Rho GTPase-activating protein involved in the signal transduction pathway. (399 aa)
gacTRho GTPase-activating protein gacT; Rho GTPase-activating protein involved in the signal transduction pathway. (1009 aa)
XacCUncharacterized protein. (1377 aa)
DDB0167574Ras-GAP domain-containing protein. (1728 aa)
gacFRho GTPase-activating protein gacF; Rho GTPase-activating protein involved in the signal transduction pathway. (1140 aa)
gefDRas guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP. (668 aa)
Dd5P4Inositol 5-phosphatase 4. (787 aa)
DDB0169348Ras-GAP domain-containing protein. (703 aa)
mgp3Mental retardation GTPase activating protein homolog 3; Rho GTPase-activating protein involved in the signal transduction pathway. (1337 aa)
gacZRho GTPase-activating protein gacZ; Rho GTPase-activating protein involved in the signal transduction pathway. (1043 aa)
roco7Probable serine/threonine-protein kinase roco7; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2615 aa)
gacORho GTPase-activating protein gacO; Rho GTPase-activating protein involved in the signal transduction pathway. (684 aa)
roco10Probable inactive serine/threonine-protein kinase roco10. (2646 aa)
roco9Probable serine/threonine-protein kinase roco9; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (3365 aa)
DG1112Developmental gene product DG1112. (1057 aa)
GacSRho-GAP domain-containing protein. (1026 aa)
gacDRho GTPase-activating protein gacD; Rho GTPase-activating protein involved in the signal transduction pathway. (514 aa)
DDB0219647Uncharacterized protein. (1918 aa)
gacEERho GTPase-activating protein gacEE; Rho GTPase-activating protein involved in the signal transduction pathway. (570 aa)
racGAPUncharacterized protein. (1350 aa)
DDB_G0293184Probable inactive serine/threonine-protein kinase DDB_G0293184. (1186 aa)
gacVRho GTPase-activating protein gacV; Rho GTPase-activating protein involved in the signal transduction pathway. (520 aa)
gacERho GTPase-activating protein gacE; Rho GTPase-activating protein involved in the signal transduction pathway. (1132 aa)
DDB0215136Uncharacterized protein. (339 aa)
gapARas GTPase-activating-like protein gapA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA in the absence of rgaA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of the dividing cell. (860 aa)
gacLRho GTPase-activating protein gacL; Rho GTPase-activating protein involved in the signal transduction pathway. (734 aa)
gacJJRho GTPase-activating protein gacJJ; Rho GTPase-activating protein involved in the signal transduction pathway. (873 aa)
gacWRho GTPase-activating protein gacW; Rho GTPase-activating protein involved in the signal transduction pathway. (1115 aa)
mgp1Mental retardation GTPase activating protein homolog 1; Rho GTPase-activating protein involved in the signal transduction pathway (By similarity). Regulator of the contractile vacuole network as well as involved in driving vacuole emptying. (920 aa)
DDB0188195Ras-GAP domain-containing protein. (817 aa)
gacXRho GTPase-activating protein gacX; Rho GTPase-activating protein involved in the signal transduction pathway. (563 aa)
rgaARas GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa)
gflBRas guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. (1601 aa)
gacKRho GTPase-activating protein gacK; Rho GTPase-activating protein involved in the signal transduction pathway. (970 aa)
gacJRho GTPase-activating protein gacJ; Rho GTPase-activating protein involved in the signal transduction pathway. (906 aa)
ngapProbable Ras GTPase-activating-like protein ngap; May function as a Ras GTPase-activating protein. (877 aa)
XacBUncharacterized protein. (1275 aa)
gacARho GTPase-activating protein gacA; Rho GTPase-activating protein involved in the signal transduction pathway. (338 aa)
gacIIRho GTPase-activating protein gacII; Rho GTPase-activating protein involved in the signal transduction pathway. (817 aa)
DDB0202463Uncharacterized protein. (1385 aa)
gacIRho GTPase-activating protein gacI; Rho GTPase-activating protein involved in the signal transduction pathway. (799 aa)
gacURho GTPase-activating protein gacU; Rho GTPase-activating protein involved in the signal transduction pathway. (1164 aa)
nfaANeurofibromin-A; Regulator of the GTPase activity of Ras, mainly RasG and RasB. (920 aa)
mgp2Mental retardation GTPase activating protein homolog 2; Rho GTPase-activating protein involved in the signal transduction pathway (By similarity). Regulator of the contractile vacuole network as well as involved in driving vacuole emptying. (877 aa)
DDB0190683Uncharacterized protein. (2044 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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