STRINGSTRING
eif2s1 eif2s1 mrps17 mrps17 psmC2 psmC2 Mcm4 Mcm4 mcm6 mcm6 DDB0167338 DDB0167338 DDB0167223 DDB0167223 lig1 lig1 exosc3 exosc3 aspS1 aspS1 asnS2 asnS2 DDB0189843 DDB0189843 rpa43 rpa43 DDB_G0269502 DDB_G0269502 maspS maspS psmC1 psmC1 Spt6 Spt6 rps23 rps23 aspS2 aspS2 polr3h-1 polr3h-1 asnS1 asnS1 DDB0202592 DDB0202592 polr2h polr2h eif1a eif1a DDB0206173 DDB0206173 metS metS DDB_G0279209 DDB_G0279209 DDB_G0279223 DDB_G0279223 Mcm3 Mcm3 rvb2 rvb2 lysS lysS rps11 rps11 MCM7 MCM7 Mcm8 Mcm8 lig3 lig3 psmC3 psmC3 psmC6 psmC6 polr2g polr2g DDB_G0285377 DDB_G0285377 DDB0186491 DDB0186491 rps28 rps28 Mcm9 Mcm9 DDB0186937 DDB0186937 DDB0218825 DDB0218825 mlysS mlysS Mcm2 Mcm2 DDB0187101 DDB0187101 DDB0187202 DDB0187202 DDB0187717 DDB0187717 DDB_G0287991 DDB_G0287991 DDB0219344 DDB0219344 DDB0188169 DDB0188169 DDB0188303 DDB0188303 Rfa1 Rfa1 DDB0188761 DDB0188761 DDB0188800 DDB0188800 dhx8 dhx8 DDB0183814 DDB0183814 DDB0231298 DDB0231298 DDB0184249 DDB0184249 lig4 lig4 mcm5 mcm5 DDB0219853 DDB0219853 DDB0192046 DDB0192046 DDB0192224 DDB0192224 mrpl2 mrpl2 mrps12 mrps12 DDB_G0282299 DDB_G0282299 psmC5 psmC5 psmC4 psmC4 eif5a eif5a rpl8 rpl8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
eif2s1Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (341 aa)
mrps17Probable 28S ribosomal protein S17, mitochondrial. (127 aa)
psmC226S proteasome regulatory subunit 7; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (428 aa)
Mcm4DNA helicase; Belongs to the MCM family. (886 aa)
mcm6DNA replication licensing factor mcm6; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit (By similarity). (867 aa)
DDB0167338tRNA-binding domain-containing protein. (458 aa)
DDB0167223Uncharacterized protein. (424 aa)
lig1DNA ligase 1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family. (1192 aa)
exosc3Putative exosome complex component rrp40; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. (237 aa)
aspS1Aspartate--tRNA ligase, cytoplasmic 1; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (576 aa)
asnS2Probable asparagine--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. (460 aa)
DDB0189843RNB domain-containing protein. (1504 aa)
rpa43Probable DNA-directed RNA polymerase I subunit RPA43; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (By similarity); Belongs to the eukaryotic RPA43 RNA polymerase subunit family. (356 aa)
DDB_G0269502Uncharacterized protein. (1791 aa)
maspSAspartate--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (692 aa)
psmC126S proteasome regulatory subunit 4 homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). Plays an important role in regulating both growth and multicellular development. (439 aa)
Spt6Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1754 aa)
rps2340S ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family. (143 aa)
aspS2Aspartate--tRNA ligase, cytoplasmic 2; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. (569 aa)
polr3h-1DNA-directed RNA polymerase III subunit rpc8; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (252 aa)
asnS1Asparagine--tRNA ligase, cytoplasmic; Belongs to the class-II aminoacyl-tRNA synthetase family. (653 aa)
DDB0202592Uncharacterized protein. (1328 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit rpabc3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively (By similarity). (142 aa)
eif1aEukaryotic translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). (141 aa)
DDB0206173DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. (1343 aa)
metSProbable methionine--tRNA ligase, cytoplasmic; Belongs to the class-I aminoacyl-tRNA synthetase family. (736 aa)
DDB_G0279209Uncharacterized protein. (132 aa)
DDB_G0279223SOSS complex subunit B homolog; Belongs to the SOSS-B family. (183 aa)
Mcm3DNA helicase; Belongs to the MCM family. (867 aa)
rvb2RuvB-like helicase 2; Has double-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription. (469 aa)
lysSLysine--tRNA ligase. (551 aa)
rps1140S ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (155 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (789 aa)
Mcm8MCM domain-containing protein; Belongs to the MCM family. (812 aa)
lig3DNA ligase 3; The alpha isoform interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. The beta isoform does not interact with XRCC1 and may be specifically involved in the completion of homologous recombination events that occur during meiotic prophase; Belongs to the ATP-dependent DNA ligase family. (1175 aa)
psmC326S proteasome regulatory subunit 6A homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (421 aa)
psmC626S proteasome regulatory subunit 10B; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (393 aa)
polr2gDNA-directed RNA polymerase II subunit rpb7; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems [...] (172 aa)
DDB_G0285377Uncharacterized protein. (156 aa)
DDB0186491RNB domain-containing protein. (1642 aa)
rps2840S ribosomal protein S28; Belongs to the eukaryotic ribosomal protein eS28 family. (72 aa)
Mcm9MCM domain-containing protein; Belongs to the MCM family. (1275 aa)
DDB0186937Uncharacterized protein. (549 aa)
DDB0218825Uncharacterized protein. (467 aa)
mlysSLeucyl-tRNA synthetase. (615 aa)
Mcm2DNA helicase; Belongs to the MCM family. (1008 aa)
DDB0187101RNB domain-containing protein. (1137 aa)
DDB0187202Uncharacterized protein. (804 aa)
DDB0187717RNB domain-containing protein. (1084 aa)
DDB_G0287991Putative uncharacterized protein DDB_G0287991. (276 aa)
DDB0219344RNB domain-containing protein. (960 aa)
DDB0188169Uncharacterized protein. (143 aa)
DDB0188303Uncharacterized protein. (632 aa)
Rfa1Uncharacterized protein. (679 aa)
DDB0188761Uncharacterized protein. (909 aa)
DDB0188800Uncharacterized protein. (316 aa)
dhx8ATP-dependent RNA helicase dhx8; Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome; Belongs to the DEAD box helicase family. DEAH subfamily. DDX8/PRP22 sub-subfamily. (1160 aa)
DDB0183814Uncharacterized protein. (380 aa)
DDB0231298Endothelial monocyte-activating polypeptide II pro-EMAP II family protein. (363 aa)
DDB0184249S1-like domain-containing protein. (183 aa)
lig4DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair; Belongs to the ATP-dependent DNA ligase family. (1088 aa)
mcm5DNA replication licensing factor mcm5; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit (By similarity). (757 aa)
DDB0219853Uncharacterized protein. (1623 aa)
DDB0192046Uncharacterized protein; Belongs to the RNR ribonuclease family. (1006 aa)
DDB0192224tRNA-binding domain-containing protein. (117 aa)
mrpl260S ribosomal protein L2, mitochondrial. (266 aa)
mrps12Ribosomal protein S12, mitochondrial. (140 aa)
DDB_G0282299BRCT domain-containing protein. (843 aa)
psmC526S proteasome regulatory subunit 8; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
psmC426S proteasome regulatory subunit 6B homolog; The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). (403 aa)
eif5aEukaryotic translation initiation factor 5A; mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis (By similarity). (159 aa)
rpl860S ribosomal protein L8; Belongs to the universal ribosomal protein uL2 family. (255 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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