33 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DDB0186510	TYR_PHOSPHATASE_2 domain-containing protein. (261 aa)
	DDB0191697	Uncharacterized protein. (453 aa)
	DDB0191668	Uncharacterized protein. (610 aa)
	DDB0219504	Uncharacterized protein. (904 aa)
	DDB0219484	Uncharacterized protein. (922 aa)
	cnrN	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa)
	DDB_G0285967	LIM-type zinc finger-containing protein. (998 aa)
	DDB0186743	TYR_PHOSPHATASE_2 domain-containing protein. (181 aa)
	DDB0186499	Uncharacterized protein. (746 aa)
	DDB0186027	Myotubularin phosphatase domain-containing protein. (1028 aa)
	DDB0185734	DSPc domain-containing protein. (249 aa)
	DDB_G0283417	Probable dual specificity protein phosphatase DDB_G0283417; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (230 aa)
	DDB_G0281963	Probable dual specificity protein phosphatase DDB_G0281963; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (394 aa)
	DDB0204242	Myotubularin phosphatase domain-containing protein. (1343 aa)
	mpl3	MAP kinase phosphatase with leucine-rich repeats protein 3; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (856 aa)
	DDB0205364	Myotubularin phosphatase domain-containing protein. (1002 aa)
	DDB0217695	Uncharacterized protein. (527 aa)
	DDB_G0273199	Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (476 aa)
	DDB_G0271350	Probable dual specificity protein phosphatase DDB_G0271350; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (275 aa)
	mpl1	MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (834 aa)
	mpl2	MAP kinase phosphatase with leucine-rich repeats protein 2; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (695 aa)
	DDB_G0269404	Probable dual specificity protein phosphatase DDB_G0269404; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (212 aa)
	DDB0189698	TYR_PHOSPHATASE_2 domain-containing protein. (262 aa)
	PLIP	Phosphatidylinositol phosphatase. (232 aa)
	DDB_G0272662	Probable protein tyrosine phosphatase type IVA B; Belongs to the protein-tyrosine phosphatase family. (163 aa)
	DDB0168530	Uncharacterized protein; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (560 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
	mkpA	MkpA protein. (1543 aa)
	ptpA1-1	Tyrosine-protein phosphatase 1; May have a role in growth and in the early stages of development. Affects the timing of development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (522 aa)
	ptpB	Tyrosine-protein phosphatase 2. (377 aa)
	ptpC	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130). (990 aa)
	DDB_G0288731	GRAM domain-containing protein. (1227 aa)
	DDB0191855	Myotubularin phosphatase domain-containing protein. (1192 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0186027	DDB0191855	Q54PL3	Q54C52	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.523
DDB0186027	DDB0204242	Q54PL3	Q54TD5	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.503
DDB0186027	DDB0205364	Q54PL3	Q54YC2	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.502
DDB0186027	DDB0219484	Q54PL3	Q54H00	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.400
DDB0186027	DDB_G0288731	Q54PL3	Q1ZXD2	Myotubularin phosphatase domain-containing protein.	GRAM domain-containing protein.	0.497
DDB0186499	DDB0191668	Q54N84	Q54CK7	Uncharacterized protein.	Uncharacterized protein.	0.407
DDB0186499	DDB_G0271350	Q54N84	Q55BI8	Uncharacterized protein.	Probable dual specificity protein phosphatase DDB_G0271350; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.406
DDB0186499	DDB_G0273199	Q54N84	Q556Y8	Uncharacterized protein.	Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.406
DDB0191668	DDB0186499	Q54CK7	Q54N84	Uncharacterized protein.	Uncharacterized protein.	0.407
DDB0191668	DDB_G0271350	Q54CK7	Q55BI8	Uncharacterized protein.	Probable dual specificity protein phosphatase DDB_G0271350; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.400
DDB0191668	DDB_G0273199	Q54CK7	Q556Y8	Uncharacterized protein.	Probable rhodanese domain-containing dual specificity protein phosphatase; Has a dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.	0.400
DDB0191697	DDB_G0285967	Q54CH3	Q54MG8	Uncharacterized protein.	LIM-type zinc finger-containing protein.	0.913
DDB0191697	pteN	Q54CH3	Q8T9S7	Uncharacterized protein.	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...]	0.916
DDB0191855	DDB0186027	Q54C52	Q54PL3	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.523
DDB0191855	DDB0204242	Q54C52	Q54TD5	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.511
DDB0191855	DDB0205364	Q54C52	Q54YC2	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.501
DDB0191855	DDB0219484	Q54C52	Q54H00	Myotubularin phosphatase domain-containing protein.	Uncharacterized protein.	0.406
DDB0191855	DDB_G0288731	Q54C52	Q1ZXD2	Myotubularin phosphatase domain-containing protein.	GRAM domain-containing protein.	0.510
DDB0204242	DDB0186027	Q54TD5	Q54PL3	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.503
DDB0204242	DDB0191855	Q54TD5	Q54C52	Myotubularin phosphatase domain-containing protein.	Myotubularin phosphatase domain-containing protein.	0.511