STRINGSTRING
DDB0206054 DDB0206054 copb2 copb2 paaf1 paaf1 mhkC mhkC lis1 lis1 DDB0169145 DDB0169145 DDB0169012 DDB0169012 Pwp1 Pwp1 Utp13 Utp13 wdsof1 wdsof1 DDB0206475 DDB0206475 DDB0186549 DDB0186549 DDB0186817 DDB0186817 DDB0186866 DDB0186866 strap strap DDB0187121 DDB0187121 wdr5 wdr5 wdr24 wdr24 DDB0187710 DDB0187710 strn strn kif8 kif8 copa copa DDB0190190 DDB0190190 corB corB DDB0190268 DDB0190268 DDB0190469 DDB0190469 ciao1 ciao1 DDB_G0288313 DDB_G0288313 nle1 nle1 DDB_G0295793 DDB_G0295793 tipD tipD tupA tupA DDB_G0349043 DDB_G0349043 gpbB gpbB mhkB mhkB DDB0219852 DDB0219852 DDB0191760 DDB0191760 gnb1l gnb1l DDB0184583 DDB0184583 lst8 lst8 DDB0187991 DDB0187991 DDB0184321 DDB0184321 DDB0184027 DDB0184027 grwd1 grwd1 DDB0189206 DDB0189206 DDB0219528 DDB0219528 morg1 morg1 Cdc40 Cdc40 DDB0186548 DDB0186548 DDB0218631 DDB0218631 Rae1 Rae1 DDB0218488 DDB0218488 mkkA mkkA agtA agtA wdr3 wdr3 rbbD rbbD mhkD mhkD DDB_G0277533 DDB_G0277533 AAC3 AAC3 gpbA gpbA mhkA mhkA TAF5 TAF5 DDB0187521 DDB0187521 Prpf4 Prpf4 Ercc8 Ercc8 snrnp40 snrnp40 smu1 smu1 Cstf1 Cstf1 DDB0218126 DDB0218126 Plrg1 Plrg1 pex7 pex7 wdr12 wdr12 DDB0206452 DDB0206452
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB0206054Uncharacterized protein. (689 aa)
copb2Coatomer subunit beta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (1005 aa)
paaf1Probable proteasomal ATPase-associated factor 1; Inhibits proteasome 26S assembly and activity by impairing the association of the 19S regulatory complex with the 20S core. Belongs to the WD repeat PAAF1/RPN14 family. (425 aa)
mhkCMyosin heavy chain kinase C; Phosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr- 2029' in the C-terminal tail region of myosin II heavy chain (mhcA) (By similarity). This phosphorylation is critical in actin-activated ATPase activity of the myosin and regulating the assembly and disassembly of myosin II filament. In vitro, catalytic domain phosphorylates mhcA, myelin basic protein, myosin regulatory light chain, casein and caldesmon. Drives the disassembly of myosin II filaments for efficient cytokinesis and recycling of myosin II that occurs during late cytokinesis. Can be ac [...] (780 aa)
lis1Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the coupling of the nucleus and centrosome and dynein/dynactin-mediated interactions of microtubule tips with the cell cortex; Belongs to the WD repeat LIS1/nudF family. (419 aa)
DDB0169145Uncharacterized protein; Belongs to the WD repeat SEC13 family. (467 aa)
DDB0169012Uncharacterized protein. (730 aa)
Pwp1WD_REPEATS_REGION domain-containing protein. (569 aa)
Utp13WD_REPEATS_REGION domain-containing protein. (902 aa)
wdsof1DDB1- and CUL4-associated factor 13; Possible role in ribosomal RNA processing. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). (445 aa)
DDB0206475Uncharacterized protein. (580 aa)
DDB0186549WD_REPEATS_REGION domain-containing protein. (399 aa)
DDB0186817Uncharacterized protein. (739 aa)
DDB0186866WD_REPEATS_REGION domain-containing protein. (767 aa)
strapSerine-threonine kinase receptor-associated protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex (By similarity); Belongs to the WD repeat STRAP family. (293 aa)
DDB0187121WD_REPEATS_REGION domain-containing protein. (694 aa)
wdr5WD repeat-containing protein 5 homolog; Belongs to the WD repeat WDR5/wds family. (335 aa)
wdr24GATOR complex protein WDR24; As a component of the GATOR complex may function in the amino acid-sensing branch of the TORC1 signaling pathway. (1023 aa)
DDB0187710Uncharacterized protein. (1864 aa)
strnStriatin homolog; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (By similarity); Belongs to the WD repeat striatin family. (827 aa)
kif8Kinesin-related protein 8; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with kif10 and dynein to organize interphase microtubules. (1873 aa)
copaCoatomer subunit alpha; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). (1221 aa)
DDB0190190WD_REPEATS_REGION domain-containing protein. (400 aa)
corBCoronin-B; Involved in phagocytosis and cell motility. Binds to actin filaments and protects them against depolymerization. Belongs to the WD repeat coronin family. (962 aa)
DDB0190268Uncharacterized protein. (923 aa)
DDB0190469Uncharacterized protein. (895 aa)
ciao1Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog; Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. (333 aa)
DDB_G0288313Uncharacterized protein. (1040 aa)
nle1WD40 repeat-containing protein. (507 aa)
DDB_G0295793WD40 repeat-containing protein. (657 aa)
tipDProtein tipD; Not known; disruption of the gene for tipD results in morphological defects. (612 aa)
tupAGeneral transcriptional corepressor tupA; Acts as component of the trfA-tupA corepressor complex which is involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacet [...] (579 aa)
DDB_G0349043WD repeat-containing protein DDB_G0349043. (588 aa)
gpbBGuanine nucleotide-binding protein subunit beta-like protein; Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (329 aa)
mhkBMyosin heavy chain kinase B; Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament; Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. (732 aa)
DDB0219852WD_REPEATS_REGION domain-containing protein. (669 aa)
DDB0191760Uncharacterized protein. (2430 aa)
gnb1lGuanine nucleotide-binding protein subunit beta-like protein 1 homolog. (359 aa)
DDB0184583Uncharacterized protein. (569 aa)
lst8Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
DDB0187991Uncharacterized protein. (549 aa)
DDB0184321Uncharacterized protein. (530 aa)
DDB0184027Uncharacterized protein. (773 aa)
grwd1Glutamate-rich WD repeat-containing protein 1. (482 aa)
DDB0189206Uncharacterized protein. (865 aa)
DDB0219528Uncharacterized protein. (649 aa)
morg1WD repeat domain-containing protein 83 homolog; Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. Also involved in response to hypoxia (By similarity). Belongs to the WD repeat MORG1 family. (325 aa)
Cdc40WD_REPEATS_REGION domain-containing protein. (595 aa)
DDB0186548WD_REPEATS_REGION domain-containing protein. (382 aa)
DDB0218631Uncharacterized protein. (807 aa)
Rae1WD_REPEATS_REGION domain-containing protein. (342 aa)
DDB0218488WD_REPEATS_REGION domain-containing protein. (772 aa)
mkkAMitogen-activated protein kinase kinase kinase A; Regulates cell-type differentiation and spatial patterning, required for the proper induction and maintenance of prespore cell differentiation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (942 aa)
agtAUDP-galactose:fucoside alpha-3-galactosyltransferase; Specifically catalyzes the transfer of a galactosyl residue to the hydroxyproline-linked saccharide on Skp1 protein (fpaA/fpaB). Catalyzes the formation of a Gal-alpha-1,3-Fuc linkage, leading to Gal- Fuc-Gal-GlcNAc-HyPro143-Skp1; Belongs to the glycosyltransferase 77 family. (648 aa)
wdr3WD repeat-containing protein 3 homolog. (942 aa)
rbbDProbable histone-binding protein rbbD; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism (By similarity). (423 aa)
mhkDMyosin heavy chain kinase D; Phosphorylates threonine (By similarity). Not critical for regulating the assembly and disassembly of myosin II filament. Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily. (941 aa)
DDB_G0277533WD repeat-containing protein 48 homolog; Belongs to the WD repeat WDR48 family. (1172 aa)
AAC3WD repeat-containing protein AAC3. (478 aa)
gpbAGuanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development. (347 aa)
mhkAMyosin heavy chain kinase A; Phosphorylates threonine in the C-terminal tail region of myosin II heavy chain. This phosphorylation is critical in regulating the assembly and disassembly of myosin II filament. Requires autophosphorylation for activity. (1146 aa)
TAF5Transcription initiation factor TFIID subunit. (948 aa)
DDB0187521WD_REPEATS_REGION domain-containing protein. (669 aa)
Prpf4WD_REPEATS_REGION domain-containing protein. (600 aa)
Ercc8Uncharacterized protein. (513 aa)
snrnp40U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome. (355 aa)
smu1WD40 repeat-containing protein smu1; Involved in pre-mRNA splicing as a component of the spliceosome. (530 aa)
Cstf1WD_REPEATS_REGION domain-containing protein. (506 aa)
DDB0218126WD_REPEATS_REGION domain-containing protein. (319 aa)
Plrg1WD_REPEATS_REGION domain-containing protein. (516 aa)
pex7Peroxisomal targeting signal 2 receptor; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import. Belongs to the WD repeat peroxin-7 family. (316 aa)
wdr12Ribosome biogenesis protein WDR12 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit. (463 aa)
DDB0206452Uncharacterized protein. (2176 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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