STRINGSTRING
DDB_G0277537 DDB_G0277537 tor tor DDB_G0287957 DDB_G0287957 PikH PikH atr1 atr1 pikD pikD pikE pikE pikC pikC pikB pikB pikA pikA DDB0218818 DDB0218818 PikG PikG dnapkcs dnapkcs DDB0218256 DDB0218256 DDB_G0279609 DDB_G0279609 smg1 smg1 DDB_G0268812 DDB_G0268812 DDB_G0268748 DDB_G0268748 PikF PikF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB_G0277537Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family. (2460 aa)
torSerine/threonine-protein kinase tor; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Functions as a part of 2 distinct protein complexes TORC1 and TORC2. TORC1 is a rapamycin-sensitive complex that controls cell growth in response to nutrients and growth factors. The second TOR complex, TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2 but not TORC1 negatively regulates phagocytosis. TORC2-dependent regulation of the cytoskeleton may follow differential phosphorylation of pkbA. May have some protein [...] (2380 aa)
DDB_G0287957Putative actin-fragmin kinase DDB_G0287957; Belongs to the protein kinase superfamily. AFK Ser/Thr protein kinase family. (540 aa)
PikHUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa)
atr1Probable serine/threonine-protein kinase atr1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q (By similarity); Belongs to the PI3/PI4-kinase family. ATM subfamily. (3157 aa)
pikDPhosphatidylinositol 4-kinase; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. (1180 aa)
pikEPhosphatidylinositol 3-kinase VPS34-like. (816 aa)
pikCPhosphatidylinositol 3-kinase 3. (1697 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
DDB0218818PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (1167 aa)
PikGUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
dnapkcsDNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Is recruited to DNA ends by the Ku70/Ku80 heterodimer and is involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination (By similarity). This activity is only apparent when DNA damage is administered in G1 phase of the cell cycle. Required for efficient signaling of DNA double-stranded breaks via phosphorylation of H2AX during G1; Belongs to the PI3/PI4-kinase family. DNAPK subfamily. (4299 aa)
DDB0218256Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1229 aa)
DDB_G0279609Putative actin-fragmin kinase DDB_G0279609; Belongs to the protein kinase superfamily. AFK Ser/Thr protein kinase family. (419 aa)
smg1Probable serine/threonine-protein kinase smg1; Serine/threonine protein kinase involved in mRNA surveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by phosphorylating upf1 (By similarity). (2344 aa)
DDB_G0268812Putative actin-fragmin kinase DDB_G0268812; Belongs to the protein kinase superfamily. AFK Ser/Thr protein kinase family. (409 aa)
DDB_G0268748Putative actin-fragmin kinase DDB_G0268748; Belongs to the protein kinase superfamily. AFK Ser/Thr protein kinase family. (436 aa)
PikFUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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