STRINGSTRING
mpl2 mpl2 carmil carmil qkgA-1 qkgA-1 gbpC gbpC gefN gefN roco4 roco4 roco9 roco9 roco10 roco10 roco11 roco11 gefV gefV pats1 pats1 mpl1 mpl1 tbce tbce DDB_G0276689 DDB_G0276689 mpl3 mpl3 DDB_G0278509 DDB_G0278509 DDB_G0278909 DDB_G0278909 roco6 roco6 drkD drkD DDB_G0281931 DDB_G0281931 slrA slrA pprA pprA roco8 roco8 GefAA GefAA DDB_G0290503 DDB_G0290503 DDB0191751 DDB0191751 lrrA lrrA roco5 roco5 AAC1 AAC1 frmC frmC gefL gefL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mpl2MAP kinase phosphatase with leucine-rich repeats protein 2; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (695 aa)
carmilProtein CARMIL; Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellul [...] (1050 aa)
qkgA-1Probable serine/threonine-protein kinase qkgA; Involved in growth, and during development, in aggregation. (1553 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
gefNRas guanine nucleotide exchange factor N; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis. (1138 aa)
roco4Probable serine/threonine-protein kinase roco4; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1726 aa)
roco9Probable serine/threonine-protein kinase roco9; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (3365 aa)
roco10Probable inactive serine/threonine-protein kinase roco10. (2646 aa)
roco11Probable serine/threonine-protein kinase roco11; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1487 aa)
gefVRas guanine nucleotide exchange factor V; Promotes the exchange of Ras-bound GDP by GTP. (1982 aa)
pats1Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa)
mpl1MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (834 aa)
tbceTubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway. (525 aa)
DDB_G0276689Protein DDB_G0276689. (2772 aa)
mpl3MAP kinase phosphatase with leucine-rich repeats protein 3; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (856 aa)
DDB_G0278509Probable serine/threonine-protein kinase DDB_G0278509; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1248 aa)
DDB_G0278909Probable inactive serine/threonine-protein kinase DDB_G0278909. (1936 aa)
roco6Probable serine/threonine-protein kinase roco6; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2147 aa)
drkDProbable serine/threonine-protein kinase drkD; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1288 aa)
DDB_G0281931Putative leucine-rich repeat-containing protein DDB_G0281931. (1211 aa)
slrAS-cell enriched with leucine-rich repeat-containing protein slrA. (1378 aa)
pprAProtein phosphatase 1 regulatory subunit pprA; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family. (336 aa)
roco8Probable serine/threonine-protein kinase roco8; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1867 aa)
GefAAUncharacterized protein. (1371 aa)
DDB_G0290503Putative leucine-rich repeat-containing protein DDB_G0290503. (1492 aa)
DDB0191751Uncharacterized protein. (702 aa)
lrrALeucine-rich repeat protein lrrA; Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis. (510 aa)
roco5Probable serine/threonine-protein kinase roco5; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor. (2800 aa)
AAC1Leucine-rich repeat-containing protein AAC1. (797 aa)
frmCFERM domain-containing protein C. (1489 aa)
gefLRas guanine nucleotide exchange factor L; Promotes the exchange of Ras-bound GDP by GTP. (2356 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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