11 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rasD	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
	mlcE	Myosin, essential light chain. (150 aa)
	calB	Calmodulin-like protein; Mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) ions. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). (149 aa)
	calA	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. (152 aa)
	pkaC	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa)
	pikA	Phosphatidylinositol 3-kinase 1. (1571 aa)
	mlcB	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes. (73 aa)
	DDB_G0289563	Calcium-binding EF-hand domain-containing protein. (74 aa)
	DDB_G0285265	Calcium-binding protein. (139 aa)
	mlcD	Myosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium. (147 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB_G0285265	DDB_G0289563	Q54NH0	Q54HC2	Calcium-binding protein.	Calcium-binding EF-hand domain-containing protein.	0.451
DDB_G0285265	calA	Q54NH0	P02599	Calcium-binding protein.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.406
DDB_G0285265	pkaC	Q54NH0	P34099	Calcium-binding protein.	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.485
DDB_G0285265	rasD	Q54NH0	P03967	Calcium-binding protein.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.505
DDB_G0289563	DDB_G0285265	Q54HC2	Q54NH0	Calcium-binding EF-hand domain-containing protein.	Calcium-binding protein.	0.451
DDB_G0289563	pkaC	Q54HC2	P34099	Calcium-binding EF-hand domain-containing protein.	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.485
DDB_G0289563	rasD	Q54HC2	P03967	Calcium-binding EF-hand domain-containing protein.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.505
calA	DDB_G0285265	P02599	Q54NH0	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Calcium-binding protein.	0.406
calA	mlcB	P02599	Q54GL7	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.	0.491
calA	pkaC	P02599	P34099	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.493
calA	rasD	P02599	P03967	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.535
calB	pkaC	O00897	P34099	Calmodulin-like protein; Mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) ions. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity).	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.486
calB	rasD	O00897	P03967	Calmodulin-like protein; Mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) ions. Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity).	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.532
mlcB	calA	Q54GL7	P02599	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.	Calmodulin; Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases.	0.491
mlcB	pkaC	Q54GL7	P34099	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.470
mlcB	rasD	Q54GL7	P03967	Myosin-IB light chain; Functions as the light chain for myosin-B. Binds calcium with submicromolar affinity and may sense physiological calcium changes.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.525
mlcD	pkaC	Q7Z2B8	P34099	Myosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium.	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.484
mlcD	rasD	Q7Z2B8	P03967	Myosin-ID light chain; Functions as the light chain for myosin-D. Has low affinity for calcium.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.505
mlcE	pkaC	P09402	P34099	Myosin, essential light chain.	cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.	0.484
mlcE	rasD	P09402	P03967	Myosin, essential light chain.	Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.	0.507