23 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	gefL	Ras guanine nucleotide exchange factor L; Promotes the exchange of Ras-bound GDP by GTP. (2356 aa)
	ptpB	Tyrosine-protein phosphatase 2. (377 aa)
	ptpC	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130). (990 aa)
	dstC	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress. (931 aa)
	gefF	Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. (1127 aa)
	gefK	Ras guanine nucleotide exchange factor K; Promotes the exchange of Ras-bound GDP by GTP. (1557 aa)
	GefAA	Uncharacterized protein. (1371 aa)
	gefA	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
	gefP	Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP. (1502 aa)
	GefBB	Uncharacterized protein. (2050 aa)
	gefO	Ras guanine nucleotide exchange factor O; Promotes the exchange of Ras-bound GDP by GTP. (944 aa)
	gefN	Ras guanine nucleotide exchange factor N; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis. (1138 aa)
	gefJ	Ras guanine nucleotide exchange factor J; Promotes the exchange of Ras-bound GDP by GTP. (812 aa)
	gefI	Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. (824 aa)
	gefH	Ras guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (604 aa)
	gefE	Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis. (1037 aa)
	gefD	Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP. (668 aa)
	gefB	Ras guanine nucleotide exchange factor B; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Involved in phagocytosis, fluid-phase endocytosis, regulation of macropinocytosis and control of cell movement. (1529 aa)
	gbpC	Cyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
	gefR	Ras guanine nucleotide exchange factor R; Promotes the exchange of Ras-bound GDP by GTP. May also play a role in the activation of rasG. (1721 aa)
	gefM	Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP. (929 aa)
	gefS	Ras guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP. (1043 aa)
	gefG	Ras guanine nucleotide exchange factor G; Promotes the exchange of Ras-bound GDP by GTP. (1556 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GefAA	dstC	Q54H95	Q54BD4	Uncharacterized protein.	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	0.404
GefAA	gefD	Q54H95	Q8IS19	Uncharacterized protein.	Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP.	0.400
GefAA	gefE	Q54H95	Q8IS18	Uncharacterized protein.	Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.	0.400
GefAA	gefM	Q54H95	Q8SSQ3	Uncharacterized protein.	Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP.	0.400
GefAA	gefN	Q54H95	Q8IS12	Uncharacterized protein.	Ras guanine nucleotide exchange factor N; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis.	0.400
GefAA	gefP	Q54H95	Q54TK8	Uncharacterized protein.	Ras guanine nucleotide exchange factor P; Promotes the exchange of Ras-bound GDP by GTP.	0.400
GefAA	ptpC	Q54H95	P54637	Uncharacterized protein.	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130).	0.531
GefBB	dstC	Q54XL4	Q54BD4	Uncharacterized protein.	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	0.405
GefBB	ptpC	Q54XL4	P54637	Uncharacterized protein.	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130).	0.531
dstC	GefAA	Q54BD4	Q54H95	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	Uncharacterized protein.	0.404
dstC	GefBB	Q54BD4	Q54XL4	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	Uncharacterized protein.	0.405
dstC	gbpC	Q54BD4	Q8MVR1	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	Cyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.	0.480
dstC	ptpB	Q54BD4	P34138	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	Tyrosine-protein phosphatase 2.	0.518
dstC	ptpC	Q54BD4	P54637	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130).	0.880
gbpC	dstC	Q8MVR1	Q54BD4	Cyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.	Signal transducer and activator of transcription C; Transcription factor that regulates gene expression during development. May play a role in regulating gene expression in response to osmotic stress.	0.480
gbpC	ptpC	Q8MVR1	P54637	Cyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.	Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130).	0.564
gefA	gefH	Q54PQ4	Q8IS16	Ras guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	Ras guanine nucleotide exchange factor H; Promotes the exchange of Ras-bound GDP by GTP. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin-dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway.	0.856
gefD	GefAA	Q8IS19	Q54H95	Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP.	Uncharacterized protein.	0.400
gefD	gefE	Q8IS19	Q8IS18	Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP.	Ras guanine nucleotide exchange factor E; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Seems to play a role in chemotaxis.	0.516
gefD	gefM	Q8IS19	Q8SSQ3	Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP.	Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP.	0.400