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gefA gefA rabif rabif rasD rasD carA-1 carA-1 gpaB gpaB pkgB pkgB rasC rasC gpaD gpaD gpaE gpaE gpaG gpaG gpaH gpaH carB carB carC carC pkbA pkbA gpaC gpaC ppa1 ppa1 erkB erkB gpaI gpaI DDB_G0282583 DDB_G0282583 gacQ gacQ scaA scaA carD carD
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
gefARas guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
rabifMss4-like family protein. (163 aa)
rasDRas-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
gpaBGuanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa)
pkgBProtein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
gpaDGuanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa)
gpaEGuanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (347 aa)
gpaGGuanine nucleotide-binding protein alpha-7 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (390 aa)
gpaHGuanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa)
carBCyclic AMP receptor 2; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. Plays a key role during tip formation and late development; involved in cAMP-directed patterning of pre stalk cells as they sort before and during tip formation; Belongs to the G-protein coupled receptor 5 family. (375 aa)
carCCyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
gpaCGuanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-3 plays a role in development. G alpha-3 mutants fail to aggregate; Belongs to the G-alpha family. (570 aa)
ppa1Inorganic pyrophosphatase; Belongs to the PPase family. (279 aa)
erkBExtracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa)
gpaIGuanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-9 antagonizes broad chemotactic response. It functions rapidly following receptor stimulation to negatively regulate PI3K/PTEN, adenylyl cyclase, and guanylyl cyclase pathways. (342 aa)
DDB_G0282583RGS domain-containing protein. (152 aa)
gacQRho GTPase-activating protein gacQ; Rho GTPase-activating protein involved in the signal transduction pathway. (531 aa)
scaASca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. (1582 aa)
carDCyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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