STRINGSTRING
racC racC myoF myoF myoE myoE forG forG brk1 brk1 pakB pakB gefS gefS pteN pteN carmil carmil racG racG rasD rasD act1 act1 rasG rasG rasC rasC rasS rasS myoB myoB coaA coaA racB racB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
myoFMyosin IF heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1071 aa)
myoEMyosin IE heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. May play a role in moving membranes relative to actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1005 aa)
forGFormin-G; Formins play an important role in the nucleation of actin and the formation of linear actin filaments. (1074 aa)
brk1Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family. (68 aa)
pakBSerine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa)
gefSRas guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP. (1043 aa)
pteN3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
carmilProtein CARMIL; Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellul [...] (1050 aa)
racGRho-related protein racG. (201 aa)
rasDRas-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa)
act1Major actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction. (376 aa)
rasGRas-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
rasSRas-like protein rasS; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (194 aa)
myoBMyosin IB heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myos [...] (1111 aa)
coaACoactosin; Binds to F-actin in a calcium independent manner. Binds to the filaments along their length. (146 aa)
racBRho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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