(23 nodes) (2018) Into the breach: how cells cope with wounds. network (Dictyostelium discoideum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	racE	Rho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa)
	racF2	Rho-related protein racF2. (193 aa)
	racG	Rho-related protein racG. (201 aa)
	racH	Rho-related protein racH. (200 aa)
	racI	Rho-related protein racI. (205 aa)
	racJ	Rho-related protein racJ. (205 aa)
	racL	Rho-related protein racL. (196 aa)
	proC	Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity). (126 aa)
	racO	Rho-related protein racO. (276 aa)
	racN	Rho-related protein racN. (219 aa)
	RacP	Rho GTPase. (376 aa)
	racM	Rho-related protein racM. (189 aa)
	racQ	Rho GTPase. (185 aa)
	racD	Rho-related protein racD; Belongs to the small GTPase superfamily. Rho family. (254 aa)
	racC	Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
	racB	Rho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa)
	racA	Rho-related protein racA. (598 aa)
	rac1C	Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa)
	rac1B	Rho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa)
	rac1A	Rho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa)
	proB	Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (124 aa)
	proA	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (126 aa)
	racF1	Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RacP	proA	Q54N82	P26199	Rho GTPase.	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.	0.560
RacP	proB	Q54N82	P26200	Rho GTPase.	Profilin-2; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.	0.562
RacP	proC	Q54N82	Q8T8M2	Rho GTPase.	Profilin-3; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).	0.560
RacP	rac1A	Q54N82	P34144	Rho GTPase.	Rho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family.	0.524
RacP	rac1B	Q54N82	P34145	Rho GTPase.	Rho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles.	0.525
RacP	rac1C	Q54N82	P34146	Rho GTPase.	Rho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles.	0.524
RacP	racB	Q54N82	P34148	Rho GTPase.	Rho-related protein racB; Belongs to the small GTPase superfamily. Rho family.	0.525
RacP	racC	Q54N82	P34149	Rho GTPase.	Rho-related protein racC; Belongs to the small GTPase superfamily. Rho family.	0.531
RacP	racE	Q54N82	Q23862	Rho GTPase.	Rho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family.	0.545
RacP	racF1	Q54N82	O96390	Rho GTPase.	Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes.	0.531
RacP	racF2	Q54N82	Q9GPS3	Rho GTPase.	Rho-related protein racF2.	0.531
RacP	racG	Q54N82	Q9GPS0	Rho GTPase.	Rho-related protein racG.	0.535
RacP	racH	Q54N82	Q9GPR7	Rho GTPase.	Rho-related protein racH.	0.547
RacP	racI	Q54N82	Q9GPR2	Rho GTPase.	Rho-related protein racI.	0.554
RacP	racL	Q54N82	Q9GPQ8	Rho GTPase.	Rho-related protein racL.	0.544
RacP	racM	Q54N82	Q54HZ7	Rho GTPase.	Rho-related protein racM.	0.540
RacP	racN	Q54N82	Q54YY4	Rho GTPase.	Rho-related protein racN.	0.554
RacP	racO	Q54N82	Q54Z85	Rho GTPase.	Rho-related protein racO.	0.553
RacP	racQ	Q54N82	Q1ZXJ6	Rho GTPase.	Rho GTPase.	0.562
proA	RacP	P26199	Q54N82	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.	Rho GTPase.	0.560