STRINGSTRING
cdk1 cdk1 racF1 racF1 racF2 racF2 racG racG racH racH racI racI racJ racJ racL racL gefS gefS racO racO racN racN vps4 vps4 RacP RacP ctnnA ctnnA racM racM racE racE racQ racQ racD racD racC racC racB racB racA racA rac1C rac1C rac1B rac1B rac1A rac1A cofA cofA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdk1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa)
racF1Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa)
racF2Rho-related protein racF2. (193 aa)
racGRho-related protein racG. (201 aa)
racHRho-related protein racH. (200 aa)
racIRho-related protein racI. (205 aa)
racJRho-related protein racJ. (205 aa)
racLRho-related protein racL. (196 aa)
gefSRas guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP. (1043 aa)
racORho-related protein racO. (276 aa)
racNRho-related protein racN. (219 aa)
vps4Vacuolar protein sorting-associated protein 4; Involved in intracellular protein transport probably out of a prevacuolar endosomal compartment. May be involved in the release of components of the bilayered coat from the endosomal membrane. The association with ESCRT-III complex mediates the ATP-dependent disassembly of the ESCRT-III complex (By similarity); Belongs to the AAA ATPase family. (444 aa)
RacPRho GTPase. (376 aa)
ctnnAProbable vinculin; Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane. Belongs to the vinculin/alpha-catenin family. (842 aa)
racMRho-related protein racM. (189 aa)
racERho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa)
racQRho GTPase. (185 aa)
racDRho-related protein racD; Belongs to the small GTPase superfamily. Rho family. (254 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
racBRho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa)
racARho-related protein racA. (598 aa)
rac1CRho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa)
rac1BRho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa)
rac1ARho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa)
cofACofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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