11 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dynB	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. (430 aa)
	dlpB	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP. (808 aa)
	proA	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. (126 aa)
	sevA	Severin; Severin blocks the ends of F-actin and causes the fragmentation and depolymerization of actin filaments in a Ca(2+) dependent manner; Belongs to the villin/gelsolin family. (362 aa)
	VilD	HP domain-containing protein. (1775 aa)
	cofA	Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa)
	dynA	Dynactin 150 kDa subunit. (1539 aa)
	lvsA	BEACH domain-containing protein lvsA; Involved in myosin-independent cytokinesis and early steps of phagocytosis. Also involved in contractile vacuole-mediated osmoregulation. (3619 aa)
	dlpA	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP. (880 aa)
	dymA	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway. (853 aa)
	dymB	Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
VilD	cofA	Q54S11	P0DJ26	HP domain-containing protein.	Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family.	0.882
VilD	proA	Q54S11	P26199	HP domain-containing protein.	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.	0.795
cofA	VilD	P0DJ26	Q54S11	Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family.	HP domain-containing protein.	0.882
cofA	proA	P0DJ26	P26199	Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family.	Profilin-1; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.	0.880
cofA	sevA	P0DJ26	P10733	Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family.	Severin; Severin blocks the ends of F-actin and causes the fragmentation and depolymerization of actin filaments in a Ca(2+) dependent manner; Belongs to the villin/gelsolin family.	0.882
dlpA	dynA	Q55F94	Q54VD6	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	Dynactin 150 kDa subunit.	0.452
dlpA	dynB	Q55F94	Q54N50	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.	0.711
dlpB	dymA	Q54MH8	Q94464	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	0.791
dlpB	dymB	Q54MH8	Q9U1M9	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.787
dlpB	dynA	Q54MH8	Q54VD6	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	Dynactin 150 kDa subunit.	0.632
dlpB	dynB	Q54MH8	Q54N50	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.	0.781
dymA	dlpB	Q94464	Q54MH8	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	0.791
dymA	dynA	Q94464	Q54VD6	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	Dynactin 150 kDa subunit.	0.452
dymA	dynB	Q94464	Q54N50	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.	0.459
dymB	dlpB	Q9U1M9	Q54MH8	Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	0.787
dynA	dlpA	Q54VD6	Q55F94	Dynactin 150 kDa subunit.	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	0.452
dynA	dlpB	Q54VD6	Q54MH8	Dynactin 150 kDa subunit.	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	0.632
dynA	dymA	Q54VD6	Q94464	Dynactin 150 kDa subunit.	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	0.452
dynA	dynB	Q54VD6	Q54N50	Dynactin 150 kDa subunit.	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.	0.998
dynB	dlpA	Q54N50	Q55F94	Dynactin subunit 2; Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis.	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	0.711