STRINGSTRING
racE racE myoJ myoJ racD racD racC racC racB racB racA racA rac1C rac1C rac1B rac1B rac1A rac1A cdk1 cdk1 myoB myoB myoA myoA mlcR mlcR cofA cofA racF1 racF1 RacP RacP racM racM racQ racQ myoK myoK dymB dymB racF2 racF2 racG racG racH racH racI racI racJ racJ racL racL dymA dymA vasp vasp racO racO fszA fszA racN racN aurK aurK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
racERho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family. (223 aa)
myoJMyosin-J heavy chain; Processive motor protein that can move over long distances along F-actin without disassociating; processiveness depends on high physiological Mg(2+) concentrations. Presents a high actin affinity in the presence of ADP, fast ATP hydrolysis, and a high steady-state ATPase activity in the presence of actin that is rate limited by ADP release. Physiological decrease of free Mg(2+) ions leads to an increased rate of ADP release and shortening of the fraction of time it spends in the strong acting binding states. (2245 aa)
racDRho-related protein racD; Belongs to the small GTPase superfamily. Rho family. (254 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
racBRho-related protein racB; Belongs to the small GTPase superfamily. Rho family. (195 aa)
racARho-related protein racA. (598 aa)
rac1CRho-related protein rac1C; Overexpression promotes the formation of filopodia and membrane ruffles. (193 aa)
rac1BRho-related protein rac1B; Overexpression promotes the formation of filopodia and membrane ruffles. (194 aa)
rac1ARho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family. (194 aa)
cdk1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa)
myoBMyosin IB heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin. Myosin IB may have a role in chemotaxis and aggregation; it could serve to stabilize and even retract cortical structures, such as pseudopods and lamellopods. Involved in the whole cell motility of aggregation-stages cells. Overexpression results in significant decrease in the rate of cellular translocation and fluid-phase pinocytosis and abnormalities in the normal rearrangement of the actin cytoskeleton. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myos [...] (1111 aa)
myoAMyosin IA heavy chain; Actin-based motor protein, possibly involved in a wide range of motile processes, such as cell movement across a surface, and extension and retraction of pseudopodia or lamellipodia; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (994 aa)
mlcRMyosin regulatory light chain. (161 aa)
cofACofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family. (137 aa)
racF1Rho-related protein racF1; Might act in concert and/or share functions with other members of the RHO family in the regulation of a subset of cytoskeletal rearrangements that are required for these processes. (193 aa)
RacPRho GTPase. (376 aa)
racMRho-related protein racM. (189 aa)
racQRho GTPase. (185 aa)
myoKMyosin-K heavy chain; Myosins are actin-based motor molecules with ATPase activity. Involved in phagocytosis and motility, and in the maintenance and dynamics of cell cortex; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (858 aa)
dymBDynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa)
racF2Rho-related protein racF2. (193 aa)
racGRho-related protein racG. (201 aa)
racHRho-related protein racH. (200 aa)
racIRho-related protein racI. (205 aa)
racJRho-related protein racJ. (205 aa)
racLRho-related protein racL. (196 aa)
dymADynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway. (853 aa)
vaspProtein VASP homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin- mediated filament elongation by bundling nascent actin filaments. Belongs to the Ena/VASP family. (380 aa)
racORho-related protein racO. (276 aa)
fszAMitochondrial division protein fszA; Probably involved in mitochondrion division process. When overexpressed, induces mitochondrial tubule formation. Binds to and hydrolyzes GTP (By similarity); Belongs to the FtsZ family. (517 aa)
racNRho-related protein racN. (219 aa)
aurKAurora kinase; Part of a chromosomal passenger complex. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. (384 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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