STRINGSTRING
rasD rasD piaA piaA csaA csaA carA-1 carA-1 rasG rasG gpaB gpaB gpaA gpaA rapA rapA rasB rasB rasC rasC gpaD gpaD gpaE gpaE gpaG gpaG gpaH gpaH pkaC pkaC racC racC pkbA pkbA smlA smlA pikA pikA pikB pikB acaA acaA ppkA ppkA lst8 lst8 rblA rblA cnrN cnrN sibA sibA gpaC gpaC grlD grlD bzpN bzpN gefA gefA gpaI gpaI cfaD cfaD elmoE elmoE I6KA I6KA gdt1 gdt1 PlaA PlaA sgcA sgcA gca gca mekA mekA gdt2 gdt2 pakD pakD gdt4 gdt4 aprA aprA DG1122 DG1122 Dd5P4 Dd5P4 gefC gefC pteN pteN amtA amtA wasA wasA iplA iplA ripA ripA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rasDRas-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (187 aa)
piaAProtein pianissimo A; Regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Required for chemoattractant receptor and G protein- mediated activation of the 12 transmembrane domain adenylyl cyclase. Functions as a part of protein complex TORC2. TORC2, is presumed to be indirectly negatively modulated by rapamycin and regulates actin polarization. TORC2, but not TORC1, negatively regulates phagocytosis. This protein and dagA protein CRAC, a cytosolic regulator, are both essential for activation of the enzyme adenylyl cyclase. This protein and CRAC do not function re [...] (1148 aa)
csaAContact site A protein; This cell-surface glycoprotein mediates cell-cell binding via homophilic interaction. (514 aa)
carA-1Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)
rasGRas-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
gpaBGuanine nucleotide-binding protein alpha-2 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses. Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Belongs to the G-alpha family. (357 aa)
gpaAGuanine nucleotide-binding protein alpha-1 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. (356 aa)
rapARas-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells. (186 aa)
rasBRas-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. (197 aa)
rasCRas-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
gpaDGuanine nucleotide-binding protein alpha-4 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-4 plays a role in morphogenesis of the multicellular structure. (345 aa)
gpaEGuanine nucleotide-binding protein alpha-5 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems; Belongs to the G-alpha family. G(q) subfamily. (347 aa)
gpaGGuanine nucleotide-binding protein alpha-7 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. (390 aa)
gpaHGuanine nucleotide-binding protein alpha-8 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-8 is a potential analog for the G(s)-like G-proteins which stimulate adenylate cyclase in mammals. (403 aa)
pkaCcAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa)
racCRho-related protein racC; Belongs to the small GTPase superfamily. Rho family. (192 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
smlASmall aggregate formation protein; Knockout of the gene for this protein causes small aggregate formation. May regulate the secretion or processing of a secreted factor that regulates aggregate size. (283 aa)
pikAPhosphatidylinositol 3-kinase 1. (1571 aa)
pikBPhosphatidylinositol 3-kinase 2. (1857 aa)
acaAAdenylate cyclase, aggregation specific; Coordinates cell aggregation by synthesizing the cAMP that influences differentiation and morphogenesis of cells within a developing multicellular structure. (1407 aa)
ppkAPolyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Produces polyP in a broad range of chain lengths (50-300 Pi residues). Involved in development (growth and fruiting body formation), sporulation, phagocytosis, cell division and the late stages of cytokinesis. (1053 aa)
lst8Protein LST8 homolog; Plays a role in regulation of adenylate cyclase and protein kinase B (PKB) activation during aggregation. Involved in both chemotaxis and signal relay; Belongs to the WD repeat LST8 family. (304 aa)
rblARetinoblastoma-like protein A; Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin- modifying enzymes to promoters (By similarity). Plays a dual role, regulating cell-cycle progression and transcriptional events leading to terminal differentiation. In the absence of a G1 phase, functions in late G2 contro [...] (1312 aa)
cnrNPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase cnrN; Protein phosphatase that negatively regulates PI3K-dependent pathways. Regulates cAMP signal transduction to control territory size. During development, a lawn of Dictyostelium cells breaks up into territories where cells aggregate in dendritic streams to form groups of 20'000 cells. (639 aa)
sibAIntegrin beta-like protein A; Implicated in cellular adhesion to substrate or phagocytic particles. (1927 aa)
gpaCGuanine nucleotide-binding protein alpha-3 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-3 plays a role in development. G alpha-3 mutants fail to aggregate; Belongs to the G-alpha family. (570 aa)
grlDMetabotropic glutamate receptor-like protein D; In the N-terminal section; belongs to the BMP lipoprotein family. (791 aa)
bzpNProbable basic-leucine zipper transcription factor N; Probable transcriptional regulator; Belongs to the bZIP family. (999 aa)
gefARas guanine nucleotide exchange factor A; Ras-bound GDP/GTP exchange factor required for normal activation of adenylyl cyclase. Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. (605 aa)
gpaIGuanine nucleotide-binding protein alpha-9 subunit; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-9 antagonizes broad chemotactic response. It functions rapidly following receptor stimulation to negatively regulate PI3K/PTEN, adenylyl cyclase, and guanylyl cyclase pathways. (342 aa)
cfaDCounting factor associated protein D; Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity. (531 aa)
elmoEELMO domain-containing protein E. (1677 aa)
I6KAKinase; Belongs to the inositol phosphokinase (IPK) family. (716 aa)
gdt1Probable inactive serine/threonine-protein kinase gdt1; Regulates the transition between growth and differentiation. In the C-terminal section; belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1661 aa)
PlaAPNPLA domain-containing protein. (386 aa)
sgcAGuanylyl cyclase. (2843 aa)
gcaGuanylyl cyclase, membrane; Synthesizes cyclic GMP (cGMP) from GTP, after activation by heterotrimeric or monomeric G proteins. Involved in chemotaxis. (1483 aa)
mekADual specificity mitogen-activated protein kinase kinase 1; Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2. (660 aa)
gdt2Probable serine/threonine-protein kinase gdt2; Regulates the transition between growth and differentiation. In the N-terminal section; belongs to the GDT family. (1637 aa)
pakDSerine/threonine-protein kinase pakD. (1678 aa)
gdt4Probable serine/threonine-protein kinase gdt4; In the C-terminal section; belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1620 aa)
aprAAutocrine proliferation repressor protein A; Inhibitor that slows proliferation of secreting cells (also known as chalone). May function by binding to cell surface receptors. Requires cfaD for activity. Overexpression slows proliferation. Belongs to the pqaA family. (494 aa)
DG1122Development protein. (713 aa)
Dd5P4Inositol 5-phosphatase 4. (787 aa)
gefCRas guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. (1457 aa)
pteN3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
amtAAmmonium transporter 1; Ammonium transporter that mediates the excretion of ammonium. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development; Belongs to the ammonia transporter channel (TC 1.A.11.2) family. (463 aa)
wasAWiscott-Aldrich syndrome protein. (399 aa)
iplAInositol 1,4,5-trisphosphate receptor-like protein A; May be a receptor for inositol 1,4,5 trisphosphate which governs calcium fluxes from the endoplasmic reticulum stores into the cytosol. May be involved in autophagic cell death. (3177 aa)
ripARas-interacting protein RIP3; Component of a Ras-regulated pathway involved in integrating chemotaxis and signal relay pathways that are essential for aggregation. (838 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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