20 items (Dictyostelium discoideum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dymB	Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (920 aa)
	carC	Cyclic AMP receptor 3; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (490 aa)
	DDB0187425	G domain-containing protein. (711 aa)
	eps15	Epidermal growth factor receptor substrate 15 homolog; May be involved in clathrin-mediated endocytosis. (1196 aa)
	dlpB	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP. (808 aa)
	DDB0204578	GB1/RHD3-type G domain-containing protein. (796 aa)
	DDB_0206311	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily. (894 aa)
	dlpC	Dynamin-like protein C; Involved in cytokinesis. May hydrolyze GTP. (904 aa)
	dlpA	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP. (880 aa)
	cytC	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). (113 aa)
	rpkA	RpkA. (828 aa)
	Dd5P4	Inositol 5-phosphatase 4. (787 aa)
	gefS	Ras guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP. (1043 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)
	dymA	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway. (853 aa)
	carD	Cyclic AMP receptor 4; Receptor for cAMP. Regulates axial patterning and cellular differentiation during late development. The activity of this receptor is mediated by G proteins; Belongs to the G-protein coupled receptor 5 family. (443 aa)
	carB	Cyclic AMP receptor 2; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. Plays a key role during tip formation and late development; involved in cAMP-directed patterning of pre stalk cells as they sort before and during tip formation; Belongs to the G-protein coupled receptor 5 family. (375 aa)
	pip5k3	1-phosphatidylinositol 3-phosphate 5-kinase; Catalyzes the phosphorylation of phosphatidylinositol 3- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. (2656 aa)
	arfA	ADP-ribosylation factor 1; GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Belongs to the small GTPase superfamily. Arf family. (182 aa)
	carA-1	Cyclic AMP receptor 1; Receptor for cAMP. Coordinates the aggregation of individual cells into a multicellular organism and regulates the expression of a large number of developmentally regulated genes. The activity of this receptor is mediated by G proteins. (392 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0187425	DDB0204578	Q54KI1	Q54TN9	G domain-containing protein.	GB1/RHD3-type G domain-containing protein.	0.847
DDB0187425	DDB_0206311	Q54KI1	Q54W90	G domain-containing protein.	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	0.817
DDB0187425	cytC	Q54KI1	Q869N1	G domain-containing protein.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).	0.574
DDB0187425	dlpA	Q54KI1	Q55F94	G domain-containing protein.	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	0.828
DDB0187425	dlpB	Q54KI1	Q54MH8	G domain-containing protein.	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	0.830
DDB0187425	dlpC	Q54KI1	Q55AX0	G domain-containing protein.	Dynamin-like protein C; Involved in cytokinesis. May hydrolyze GTP.	0.834
DDB0187425	dymA	Q54KI1	Q94464	G domain-containing protein.	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	0.681
DDB0187425	dymB	Q54KI1	Q9U1M9	G domain-containing protein.	Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.684
DDB0187425	eps15	Q54KI1	Q54KI4	G domain-containing protein.	Epidermal growth factor receptor substrate 15 homolog; May be involved in clathrin-mediated endocytosis.	0.432
DDB0204578	DDB0187425	Q54TN9	Q54KI1	GB1/RHD3-type G domain-containing protein.	G domain-containing protein.	0.847
DDB0204578	DDB_0206311	Q54TN9	Q54W90	GB1/RHD3-type G domain-containing protein.	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	0.790
DDB0204578	dlpA	Q54TN9	Q55F94	GB1/RHD3-type G domain-containing protein.	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	0.757
DDB0204578	dlpB	Q54TN9	Q54MH8	GB1/RHD3-type G domain-containing protein.	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	0.760
DDB0204578	dlpC	Q54TN9	Q55AX0	GB1/RHD3-type G domain-containing protein.	Dynamin-like protein C; Involved in cytokinesis. May hydrolyze GTP.	0.763
DDB0204578	dymA	Q54TN9	Q94464	GB1/RHD3-type G domain-containing protein.	Dynamin-A; Function in membrane trafficking processes along the endo- lysosomal pathway.	0.549
DDB0204578	dymB	Q54TN9	Q9U1M9	GB1/RHD3-type G domain-containing protein.	Dynamin-B; Enzyme hydrolyzing GTP; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.	0.553
DDB_0206311	DDB0187425	Q54W90	Q54KI1	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	G domain-containing protein.	0.817
DDB_0206311	DDB0204578	Q54W90	Q54TN9	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	GB1/RHD3-type G domain-containing protein.	0.790
DDB_0206311	dlpA	Q54W90	Q55F94	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	Dynamin-like protein A; Involved in cytokinesis. May hydrolyze GTP.	0.547
DDB_0206311	dlpB	Q54W90	Q54MH8	Protein SEY1 homolog; Probable GTP-binding protein that may be involved in cell development; Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. RHD3 subfamily.	Dynamin-like protein B; Involved in cytokinesis. May hydrolyze GTP.	0.704