STRINGSTRING
svkA svkA mkcB mkcB cdk8 cdk8 sepA sepA mkcD mkcD DDB_G0277449 DDB_G0277449 dst1 dst1 nek3 nek3 PLK PLK atg1 atg1 DDB_G0271550 DDB_G0271550 DDB_G0275057 DDB_G0275057 pakF pakF pakB pakB DDB_G0277165 DDB_G0277165 dyrk1 dyrk1 pakC pakC DDB_G0267514 DDB_G0267514 cdk10 cdk10 dst2 dst2 tsuA tsuA krsB krsB DDB_G0268078 DDB_G0268078 pakD pakD pakA pakA mekA mekA mkcF mkcF DDB_G0270146 DDB_G0270146 glkA glkA nek2 nek2 DDB_G0272282 DDB_G0272282 Cdk9-1 Cdk9-1 pakH-1 pakH-1 DDB_G0272797 DDB_G0272797 pkgA pkgA fray2 fray2 snfA snfA ndrA ndrA DDB_G0278487 DDB_G0278487 fray1 fray1 DDB_G0278901 DDB_G0278901 aurK aurK DDB_G0279405 DDB_G0279405 lkb1 lkb1 prpf4B prpf4B DDB_G0279831 DDB_G0279831 DDB_G0280133 DDB_G0280133 fhkE fhkE DDB_G0280717 DDB_G0280717 pdkA pdkA mkcE mkcE mrkC mrkC DDB_G0282429 DDB_G0282429 pakG pakG iksA iksA cdk11 cdk11 mkkA mkkA yakA yakA DDB_G0283821 DDB_G0283821 nek1 nek1 erkB erkB DDB_G0284251 DDB_G0284251 pdkB pdkB DDB_G0284661 DDB_G0284661 ndrC ndrC mkcA mkcA mrkB mrkB fhkD fhkD DDB_G0286481 DDB_G0286481 DDB_G0286841 DDB_G0286841 mkcC mkcC dst4 dst4 ndrB ndrB DDB_G0288795 DDB_G0288795 Nek4 Nek4 ndrD ndrD DDB_G0290859 DDB_G0290859 dst3 dst3 mrkA mrkA DDB_G0292350 DDB_G0292350 DDB_G0292550 DDB_G0292550 DDB_G0292624 DDB_G0292624 DDB_G0293276 DDB_G0293276 fhkA fhkA dyrk2 dyrk2 pakE pakE DDB_G0278845 DDB_G0278845 fhkB fhkB pXi pXi casK casK cdk7 cdk7 pkbA pkbA gskA gskA erkA erkA cdk5 cdk5 cdk1 cdk1 pkgD pkgD pkgC pkgC fhkC fhkC pkaD pkaD pkaC pkaC pkgB pkgB mlkA mlkA krsA krsA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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svkASerine/threonine-protein kinase svkA; Involved in regulation of actin cytoskeleton organization during cell motility; F-actin fragmenting and capping protein allowing dynamic rearrangements of the actin cytoskeleton. Also part of a regulatory pathway from the centrosome to the midzone, thus regulating the completion of cell division; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (478 aa)
mkcBProbable serine/threonine-protein kinase mkcB; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (714 aa)
cdk8Probable cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) [...] (380 aa)
sepASerine/threonine-protein kinase sepA; Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells. (1167 aa)
mkcDProbable serine/threonine-protein kinase mkcD. (652 aa)
DDB_G0277449Probable serine/threonine-protein kinase DDB_G0277449; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (456 aa)
dst1Serine/threonine-protein kinase dst1. (737 aa)
nek3Probable serine/threonine-protein kinase nek3; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (1123 aa)
PLKProbable serine/threonine-protein kinase PLK; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. (978 aa)
atg1Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium. (668 aa)
DDB_G0271550Probable myosin light chain kinase DDB_G0271550; May phosphorylate a specific serine in the N-terminus of a myosin light chain. (392 aa)
DDB_G0275057Probable myosin light chain kinase DDB_G0275057; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (349 aa)
pakFSerine/threonine-protein kinase pakF. (1176 aa)
pakBSerine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (852 aa)
DDB_G0277165Probable serine/threonine-protein kinase DDB_G0277165; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (833 aa)
dyrk1Probable serine/threonine-protein kinase dyrk1. (836 aa)
pakCSerine/threonine-protein kinase pakC; Has role in the regulation of chemotaxis. (477 aa)
DDB_G0267514Probable serine/threonine-protein kinase DDB_G0267514; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (916 aa)
cdk10Probable cyclin-dependent kinase 10. (366 aa)
dst2Serine/threonine-protein kinase dst2. (1142 aa)
tsuAProbable serine/threonine-protein kinase tsuA; Plays a role in chemotaxis and seems to be involved in polarization. (2247 aa)
krsBSerine/threonine-protein kinase 4 homolog B; Probable serine/threonine-protein kinase; In the N-terminal section; belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1105 aa)
DDB_G0268078Probable serine/threonine-protein kinase DDB_G0268078; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (507 aa)
pakDSerine/threonine-protein kinase pakD. (1678 aa)
pakASerine/threonine-protein kinase pakA; Regulator of the myosin II component of the cytoskeleton: required for regulation of cytokinesis. Functions during chemotaxis, required for maintaining the direction of cell movement, suppressing lateral pseudopod extension, and proper retraction of the posterior of chemotaxing cells; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1197 aa)
mekADual specificity mitogen-activated protein kinase kinase 1; Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2. (660 aa)
mkcFProbable serine/threonine-protein kinase mkcF. (677 aa)
DDB_G0270146Probable serine/threonine-protein kinase DDB_G0270146. (635 aa)
glkAProbable serine/threonine-protein kinase glkA; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. (473 aa)
nek2Probable serine/threonine-protein kinase nek2; Involved in centrosome biogenesis. Seems to be required for recruitment of centrosomal material and might be involved in de novo centrosome formation. (418 aa)
DDB_G0272282Probable serine/threonine-protein kinase DDB_G0272282; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2102 aa)
Cdk9-1Protein kinase domain-containing protein. (694 aa)
pakH-1Serine/threonine-protein kinase pakH; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (513 aa)
DDB_G0272797Putative cyclin-dependent serine/threonine-protein kinase DDB_G0272797/DDB_G0274007; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (680 aa)
pkgAProbable serine/threonine-protein kinase pkgA; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1367 aa)
fray2Serine/threonine-protein kinase fray2; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (1028 aa)
snfA5'-AMP-activated serine/threonine-protein kinase catalytic subunit alpha; Activated enzyme phosphorylates target proteins and initiates downstream signaling pathways that shift metabolism from anabolic to catabolic pathways. Acts as a highly sensitive cellular energy sensor. (727 aa)
ndrAProbable serine/threonine-protein kinase ndrA. (530 aa)
DDB_G0278487Probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487. (636 aa)
fray1Serine/threonine-protein kinase fray1; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (574 aa)
DDB_G0278901Probable serine/threonine-protein kinase DDB_G0278901. (1495 aa)
aurKAurora kinase; Part of a chromosomal passenger complex. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. (384 aa)
DDB_G0279405Probable serine/threonine-protein kinase DDB_G0279405; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (695 aa)
lkb1Serine/threonine-protein kinase stk11 homolog; Serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. (586 aa)
prpf4BSerine/threonine-protein kinase prpf4B; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. (811 aa)
DDB_G0279831Probable myosin light chain kinase DDB_G0279831; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (928 aa)
DDB_G0280133Probable serine/threonine-protein kinase DDB_G0280133; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (1505 aa)
fhkEProbable serine/threonine-protein kinase fhkE; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (712 aa)
DDB_G0280717Probable serine/threonine-protein kinase DDB_G0280717; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (411 aa)
pdkAProbable serine/threonine-protein kinase pdkA. (686 aa)
mkcEProbable serine/threonine-protein kinase mkcE. (715 aa)
mrkCProbable serine/threonine-protein kinase MARK-C; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (773 aa)
DDB_G0282429Probable myosin light chain kinase DDB_G0282429; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (312 aa)
pakGSerine/threonine-protein kinase pakG. (1179 aa)
iksAProbable serine/threonine-protein kinase iksA. (979 aa)
cdk11Cyclin-dependent kinase 11; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (358 aa)
mkkAMitogen-activated protein kinase kinase kinase A; Regulates cell-type differentiation and spatial patterning, required for the proper induction and maintenance of prespore cell differentiation; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (942 aa)
yakAProbable serine/threonine-protein kinase yakA; General sensor of environmental conditions, such as heat stress, effecting changes through pkaC. Essential for survival to nitrosoative and oxidative stresses. Required for cell cycle control, not only at the onset but also during development (aggregation process and postaggregative development). (1458 aa)
DDB_G0283821Serine/threonine-protein kinase DDB_G0283821; May play a role in responding to changes in cAMP levels. (941 aa)
nek1Probable serine/threonine-protein kinase nek1; Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. (485 aa)
erkBExtracellular signal-regulated kinase 2; Implicated in the relay of the cAMP chemotactic signal and cell differentiation. Important for receptor-mediated activation of adenylyl cyclase. (369 aa)
DDB_G0284251Probable serine/threonine-protein kinase DDB_G0284251. (496 aa)
pdkB3-phosphoinositide-dependent protein kinase B. (908 aa)
DDB_G0284661Probable myosin light chain kinase DDB_G0284661; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (481 aa)
ndrCProbable serine/threonine-protein kinase ndrC; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1335 aa)
mkcAProbable serine/threonine-protein kinase mkcA; Coordinates organism morphology with cellular differentiation during development. Negative regulator of sporulation, synchronizing encapsulation with culmination. May have an additional function in prestalk cells. (860 aa)
mrkBProbable serine/threonine-protein kinase MARK-B; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (715 aa)
fhkDProbable serine/threonine-protein kinase fhkD; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (749 aa)
DDB_G0286481Probable serine/threonine-protein kinase DDB_G0286481. (605 aa)
DDB_G0286841Probable serine/threonine-protein kinase DDB_G0286841; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (462 aa)
mkcCProbable serine/threonine-protein kinase mkcC. (891 aa)
dst4Serine/threonine-protein kinase dst4. (485 aa)
ndrBProbable serine/threonine-protein kinase ndrB. (542 aa)
DDB_G0288795Probable serine/threonine-protein kinase DDB_G0288795. (641 aa)
Nek4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (498 aa)
ndrDProbable serine/threonine-protein kinase ndrD; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2112 aa)
DDB_G0290859Probable serine/threonine-protein kinase DDB_G0290859; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (419 aa)
dst3Serine/threonine-protein kinase dst3. (562 aa)
mrkAProbable serine/threonine-protein kinase MARK-A; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (1060 aa)
DDB_G0292350Probable serine/threonine-protein kinase DDB_G0292350. (1224 aa)
DDB_G0292550Probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (1397 aa)
DDB_G0292624Probable myosin light chain kinase DDB_G0292624; May phosphorylate a specific serine in the N-terminus of a myosin light chain; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. (313 aa)
DDB_G0293276Probable serine/threonine-protein kinase DDB_G0293276; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (516 aa)
fhkAProbable serine/threonine-protein kinase fhkA; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (593 aa)
dyrk2Probable serine/threonine-protein kinase dyrk2. (915 aa)
pakESerine/threonine-protein kinase pakE; May play a role in responding to changes in chemoattractant levels. (926 aa)
DDB_G0278845Probable serine/threonine-protein kinase DDB_G0278845; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1350 aa)
fhkBProbable serine/threonine-protein kinase fhkB; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (1142 aa)
pXiProbable serine/threonine-protein kinase pXi; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (691 aa)
casKCasein kinase II subunit alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CK2 subfamily. (337 aa)
cdk7Cyclin-dependent kinase 7; Catalytic part of CAK which activates cyclin-associated CDK1/CDK2/CDK4 by threonine phosphorylation, thereby allowing MPF activation. (360 aa)
pkbARAC family serine/threonine-protein kinase homolog; Predominantly involved during the aggregation to control cell polarity and chemotaxis. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. (444 aa)
gskAGlycogen synthase kinase-3; During cellular differentiation, may mediate an extracellular cyclic AMP stimulated signal transduction pathway that regulates prespore and prestalk B-cell proportions through inhibition of stalk cell formation and induction of prespore cell differentiation. The cAMP receptor carC appears to activate gskA via the tyrosine kinases zakA and zak2, to stimulate prespore differentiation, while carD appears to negatively regulate gskA, to promote prestalk formation. (467 aa)
erkAExtracellular signal-regulated kinase 1; Kinase involved in a signal transduction pathway. (529 aa)
cdk5Cyclin-dependent kinase 5 homolog. (292 aa)
cdk1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (296 aa)
pkgDProtein kinase 4; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (992 aa)
pkgCProtein kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (910 aa)
fhkCProbable serine/threonine-protein kinase fhkC; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily. (595 aa)
pkaDDevelopmentally-regulated protein kinase 1. (714 aa)
pkaCcAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis. (648 aa)
pkgBProtein kinase 2; Required for morphogenesis during multicellular development. Phosphorylates talB, gefN, gefS, PI4P 5-kinase and gacQ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (479 aa)
mlkAMyosin light chain kinase A; Phosphorylates a specific serine in the N-terminus of a myosin light chain (By similarity). Phosphorylates regulatory myosin light chain (mlcR) during chemotaxis. (295 aa)
krsASerine/threonine-protein kinase 4 homolog A; Regulates both cAMP signaling during early development and the stress response. Functions as an activator of adenylylcyclase. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. (461 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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