STRINGSTRING
DDB0168311 DDB0168311 DG1112 DG1112 DDB0217803 DDB0217803 DDB0167554 DDB0167554 gbpC gbpC DDB0167472 DDB0167472 DDB0187476 DDB0187476 carmil carmil DDB0187577 DDB0187577 DDB0187660 DDB0187660 DDB0187745 DDB0187745 DDB0188475 DDB0188475 GefAA GefAA DDB0219527 DDB0219527 DDB0188882 DDB0188882 DDB0219582 DDB0219582 dlrA dlrA DDB0183884 DDB0183884 DDB0183955 DDB0183955 DDB0191751 DDB0191751 DDB0191867 DDB0191867 DDB0192162 DDB0192162 DDB_G0293920 DDB_G0293920 lrrA lrrA DDB_G0278635 DDB_G0278635 roco5 roco5 frmC frmC DDB_G0295827 DDB_G0295827 gefL gefL roco11 roco11 roco10 roco10 roco9 roco9 roco4 roco4 DDB0216561 DDB0216561 gefV gefV DDB0190065 DDB0190065 pats1 pats1 mpl2 mpl2 mpl1 mpl1 tbce tbce DDB0190861 DDB0190861 DDB0217098 DDB0217098 DDB0217795 DDB0217795 DDB0204455 DDB0204455 DDB0204456 DDB0204456 DDB0218071 DDB0218071 mpl3 mpl3 DDB_G0278509 DDB_G0278509 DDB0205779 DDB0205779 roco6 roco6 DDB0205814 DDB0205814 DDB0206005 DDB0206005 DDB0206051 DDB0206051 drkD drkD DDB0204653 DDB0204653 DDB_G0281931 DDB_G0281931 DDB_G0282783 DDB_G0282783 DDB0204863 DDB0204863 VilD VilD DDB_G0283683 DDB_G0283683 pprA pprA DDB0186020 DDB0186020 DDB0218617 DDB0218617 DDB0186377 DDB0186377 DDB0186571 DDB0186571 DDB0218778 DDB0218778 roco8 roco8 DDB0187019 DDB0187019
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDB0168311Uncharacterized protein. (882 aa)
DG1112Developmental gene product DG1112. (1057 aa)
DDB0217803Uncharacterized protein. (816 aa)
DDB0167554Uncharacterized protein. (880 aa)
gbpCCyclic GMP-binding protein C; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Required for cyclic GMP-mediated chemotaxis, polarity. Plays a key role in cyclic AMP-induced myosin II translocation to the cortex. Also involved in the phosphorylation of mlkA and mlcR, either directly or via an intermediate kinase. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2631 aa)
DDB0167472F-box domain-containing protein. (638 aa)
DDB0187476Uncharacterized protein. (1012 aa)
carmilProtein CARMIL; Serves as the scaffold for the assembly of a complex that links key players in the nucleation and termination of actin filament assembly with a ubiquitous barbed end-directed motor. This complex is composed of at least capping proteins (acpA and acpB), the Arp2/3 complex, type I myosins (myoB and myoC) and carmil. It has at least a modest ability to activate Arp2/3-dependent actin nucleation. CARMIL localizes along with the Arp2/3 complex, myoB, and myoC in the leading edge of cells and it plays a significant role in the structure and function of these actin-rich cellul [...] (1050 aa)
DDB0187577Uncharacterized protein. (742 aa)
DDB0187660SH2 domain-containing protein. (854 aa)
DDB0187745Uncharacterized protein. (2209 aa)
DDB0188475Uncharacterized protein. (498 aa)
GefAAUncharacterized protein. (1371 aa)
DDB0219527Uncharacterized protein. (838 aa)
DDB0188882Uncharacterized protein. (693 aa)
DDB0219582Uncharacterized protein. (368 aa)
dlrAUncharacterized protein. (818 aa)
DDB0183884Response regulatory domain-containing protein. (902 aa)
DDB0183955Uncharacterized protein. (285 aa)
DDB0191751Uncharacterized protein. (702 aa)
DDB0191867Uncharacterized protein. (1145 aa)
DDB0192162Uncharacterized protein. (800 aa)
DDB_G0293920Uncharacterized protein. (861 aa)
lrrALeucine-rich repeat protein lrrA; Involved in cytoskeleton remodeling, which is needed for normal chemotactic aggregation and efficient cell sorting during multicellular morphogenesis. (510 aa)
DDB_G0278635Leucine-rich repeat-containing protein. (624 aa)
roco5Probable serine/threonine-protein kinase roco5; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor. (2800 aa)
frmCFERM domain-containing protein C. (1489 aa)
DDB_G0295827Leucine-rich repeat-containing protein. (572 aa)
gefLRas guanine nucleotide exchange factor L; Promotes the exchange of Ras-bound GDP by GTP. (2356 aa)
roco11Probable serine/threonine-protein kinase roco11; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1487 aa)
roco10Probable inactive serine/threonine-protein kinase roco10. (2646 aa)
roco9Probable serine/threonine-protein kinase roco9; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (3365 aa)
roco4Probable serine/threonine-protein kinase roco4; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1726 aa)
DDB0216561F-box domain-containing protein. (676 aa)
gefVRas guanine nucleotide exchange factor V; Promotes the exchange of Ras-bound GDP by GTP. (1982 aa)
DDB0190065WD_REPEATS_REGION domain-containing protein. (1019 aa)
pats1Probable serine/threonine-protein kinase pats1; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor (By similarity). Essential regulator of cytokinesis involved in the binding to actomyosin cytoskeleton. (3184 aa)
mpl2MAP kinase phosphatase with leucine-rich repeats protein 2; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (695 aa)
mpl1MAP kinase phosphatase with leucine-rich repeats protein 1; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins (By similarity). Dephosphorylates pNPP, in vitro. Essential for proper regulation of erkB (erk2) and optimal motility during development; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (834 aa)
tbceTubulin-specific chaperone E; Tubulin-folding protein; involved in the second step of the tubulin folding pathway. (525 aa)
DDB0190861PPM-type phosphatase domain-containing protein. (1359 aa)
DDB0217098RGS domain-containing protein. (1565 aa)
DDB0217795Uncharacterized protein. (2159 aa)
DDB0204455Clu domain-containing protein. (1701 aa)
DDB0204456Uncharacterized protein. (239 aa)
DDB0218071Uncharacterized protein. (717 aa)
mpl3MAP kinase phosphatase with leucine-rich repeats protein 3; Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (856 aa)
DDB_G0278509Probable serine/threonine-protein kinase DDB_G0278509; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1248 aa)
DDB0205779Uncharacterized protein. (540 aa)
roco6Probable serine/threonine-protein kinase roco6; May act as a serine/threonine-protein kinase and guanine- nucleotide releasing factor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (2147 aa)
DDB0205814Uncharacterized protein. (617 aa)
DDB0206005Uncharacterized protein. (1084 aa)
DDB0206051Uncharacterized protein. (1019 aa)
drkDProbable serine/threonine-protein kinase drkD; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. (1288 aa)
DDB0204653Uncharacterized protein. (396 aa)
DDB_G0281931Putative leucine-rich repeat-containing protein DDB_G0281931. (1211 aa)
DDB_G0282783Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (3017 aa)
DDB0204863Uncharacterized protein. (552 aa)
VilDHP domain-containing protein. (1775 aa)
DDB_G0283683Leucine-rich repeat-containing protein. (521 aa)
pprAProtein phosphatase 1 regulatory subunit pprA; Regulatory subunit of protein phosphatase 1; Belongs to the SDS22 family. (336 aa)
DDB0186020C2 domain-containing protein. (623 aa)
DDB0218617Uncharacterized protein. (982 aa)
DDB0186377Uncharacterized protein. (473 aa)
DDB0186571F-box domain-containing protein. (283 aa)
DDB0218778Uncharacterized protein. (1070 aa)
roco8Probable serine/threonine-protein kinase roco8; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily. (1867 aa)
DDB0187019Uncharacterized protein. (722 aa)
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.