39 items (Dictyostelium discoideum) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	pip5k3	1-phosphatidylinositol 3-phosphate 5-kinase; Catalyzes the phosphorylation of phosphatidylinositol 3- phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. (2656 aa)
	pikA	Phosphatidylinositol 3-kinase 1. (1571 aa)
	pikB	Phosphatidylinositol 3-kinase 2. (1857 aa)
	pikC	Phosphatidylinositol 3-kinase 3. (1697 aa)
	pikE	Phosphatidylinositol 3-kinase VPS34-like. (816 aa)
	pikD	Phosphatidylinositol 4-kinase; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. (1180 aa)
	plc	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (801 aa)
	DDB_G0288731	GRAM domain-containing protein. (1227 aa)
	DDB0191697	Uncharacterized protein. (453 aa)
	Dd5P3	Inositol 5-phosphatase. (1379 aa)
	DDB0219722	PIPK domain-containing protein. (944 aa)
	PikH	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1820 aa)
	DDB0219574	Uncharacterized protein. (1717 aa)
	miox	Inositol oxygenase; Belongs to the myo-inositol oxygenase family. (292 aa)
	DDB0219484	Uncharacterized protein. (922 aa)
	mmsdh	Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity); Belongs to the aldehyde dehydrogenase family. (528 aa)
	DDB0187902	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (519 aa)
	DDB0218876	Uncharacterized protein; Belongs to the histidine acid phosphatase family. (507 aa)
	DDB0218818	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (1167 aa)
	DDB_G0285967	LIM-type zinc finger-containing protein. (998 aa)
	ino1	Inositol-3-phosphate synthase; Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1- phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). (511 aa)
	mipp1	Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. Belongs to the histidine acid phosphatase family. MINPP1 subfamily. (635 aa)
	DDB0218645	CDP-diacylglycerol--inositol 3-phosphatidyltransferase. (207 aa)
	PikG	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1671 aa)
	DDB0204639	Kinase; Belongs to the inositol phosphokinase (IPK) family. (284 aa)
	DDB0205575	SAC domain-containing protein. (1391 aa)
	impa1	Inositol monophosphatase; Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides. Has broad substrate specificity and can use myo-inositol monophosphates, myo- inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo- inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. (272 aa)
	DDB_G0277537	Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family. (2460 aa)
	DDB0203614	Kinase; Belongs to the inositol phosphokinase (IPK) family. (307 aa)
	sac1	Phosphatidylinositide phosphatase SAC1; Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. (581 aa)
	DDB0216866	Myotubularin phosphatase domain-containing protein. (1738 aa)
	ITPK1	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family. (326 aa)
	DDB_G0268652	3'(2'),5'-bisphosphate nucleotidase; Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Regulates the flux of sulfur in the sulfur- activation pathway by converting PAPS to APS. Is also able to hydrolyze inositol 1,4-bisphosphate and inositol 1,3,4-trisphosphate (By similarity). (332 aa)
	PikF	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1382 aa)
	DDB_G0267588	Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation. (719 aa)
	tpiA	Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (257 aa)
	PIPkinA	Uncharacterized protein. (1589 aa)
	Dd5P4	Inositol 5-phosphatase 4. (787 aa)
	pteN	3-phosphatidylinositol 3-phosphatase; Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5- trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate (By similarity). Negative regulator of PI3K chemotaxis pathways. Overexpression leads to a suppression of a PI3K-dependent activation of pkbA, and these cells exhibit chemotax [...] (533 aa)

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0187902	DDB0203614	Q54J22	Q55AP4	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.937
DDB0187902	DDB0204639	Q54J22	Q54TI0	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	Kinase; Belongs to the inositol phosphokinase (IPK) family.	0.936
DDB0187902	DDB0218645	Q54J22	Q54P27	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	CDP-diacylglycerol--inositol 3-phosphatidyltransferase.	0.485
DDB0187902	DDB0218876	Q54J22	Q54L08	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	Uncharacterized protein; Belongs to the histidine acid phosphatase family.	0.442
DDB0187902	ITPK1	Q54J22	Q55D87	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	Inositol-tetrakisphosphate 1-kinase; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Belongs to the ITPK1 family.	0.904
DDB0187902	mipp1	Q54J22	Q54ND5	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).	Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. Belongs to the histidine acid phosphatase family. MINPP1 subfamily.	0.442
DDB0191697	DDB0218645	Q54CH3	Q54P27	Uncharacterized protein.	CDP-diacylglycerol--inositol 3-phosphatidyltransferase.	0.915
DDB0191697	DDB0218818	Q54CH3	Q54LR9	Uncharacterized protein.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	DDB0219574	Q54CH3	Q54FY6	Uncharacterized protein.	Uncharacterized protein.	0.907
DDB0191697	DDB0219722	Q54CH3	Q54DL4	Uncharacterized protein.	PIPK domain-containing protein.	0.908
DDB0191697	DDB_G0267588	Q54CH3	Q55GN6	Uncharacterized protein.	Probable phosphatidylinositol phosphate kinase DDB_G0267588; May be involved in signaling events that underlie chemotaxis via the chemoattractant-mediated pkgB phosphorylation.	0.908
DDB0191697	DDB_G0277537	Q54CH3	Q54ZN9	Uncharacterized protein.	Phosphatidylinositol 4-kinase; Belongs to the PI3/PI4-kinase family.	0.902
DDB0191697	DDB_G0285967	Q54CH3	Q54MG8	Uncharacterized protein.	LIM-type zinc finger-containing protein.	0.913
DDB0191697	Dd5P3	Q54CH3	Q54D97	Uncharacterized protein.	Inositol 5-phosphatase.	0.914
DDB0191697	Dd5P4	Q54CH3	Q8I7P3	Uncharacterized protein.	Inositol 5-phosphatase 4.	0.908
DDB0191697	PIPkinA	Q54CH3	Q86A02	Uncharacterized protein.	Uncharacterized protein.	0.908
DDB0191697	PikF	Q54CH3	Q55FX5	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	PikG	Q54CH3	Q54S78	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	PikH	Q54CH3	Q54F55	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.900
DDB0191697	pikA	Q54CH3	P54673	Uncharacterized protein.	Phosphatidylinositol 3-kinase 1.	0.923