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| | DDB_G0295811 | Thioredoxin fold domain-containing protein. (303 aa) |
| | nosA | NOSA. (1089 aa) |
| | culA | Cullin-1; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Required at several stages during development. CulA and fbxA regulate multicellular development by targeting regA for degradation via a pathway that requires erkB function, leading to an increase in cAMP and PKA activity. (770 aa) |
| | hspB | Heat shock cognate 70 kDa protein 1; Affects actin polymerization through interaction with the actin-binding protein CAP32/34 (acpA/acpB). Acts as a chaperone by stimulating the refolding of denaturated acpA and acpB, but neither stimulates nor inhibits the capping activity of native CAP32/34. Belongs to the heat shock protein 70 family. (640 aa) |
| | fpaA | SCF ubiquitin ligase complex protein SKP1a(4-162); Belongs to the SKP1 family. (162 aa) |
| | hspD | Heat shock cognate 90 kDa protein; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family. (700 aa) |
| | cdcD | Cell division cycle protein 48; Belongs to the AAA ATPase family. (793 aa) |
| | crtA | Calreticulin; Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity). (424 aa) |
| | DDB_G0294380 | Ubiquitin-conjugating enzyme E2 J2-like; Catalyzes the covalent attachment of ubiquitin to other proteins. (170 aa) |
| | DDB_G0293678 | Heat shock cognate 70 kDa protein 4; May function in protein folding and assembly, and disassembly of protein complexes. (569 aa) |
| | DDB_G0293674 | Heat shock cognate 70 kDa protein 3; May function in protein folding and assembly, and disassembly of protein complexes. (630 aa) |
| | nsfl1c | NSFL1 cofactor p47 homolog; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity). (415 aa) |
| | ost1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (460 aa) |
| | DDB0191696 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (575 aa) |
| | sec13 | Protein SEC13 homolog; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 [...] (301 aa) |
| | ddost | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (426 aa) |
| | pdi2 | Protein disulfide-isomerase 2; Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. (513 aa) |
| | DDB0189206 | Uncharacterized protein. (865 aa) |
| | ost2 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the en [...] (120 aa) |
| | DDB0188947 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa) |
| | nploc4 | Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family. (576 aa) |
| | swp1 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit swp1; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the [...] (685 aa) |
| | DDB0188144 | Uncharacterized protein. (553 aa) |
| | derl1 | Probable derlin-1 homolog; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Belongs to the derlin family. (242 aa) |
| | DDB0187676 | RING-type domain-containing protein. (688 aa) |
| | sec61g | Protein transport protein Sec61 subunit gamma; Necessary for protein translocation in the endoplasmic reticulum. (69 aa) |
| | rbx1 | RING-box protein 1; Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme to the complex and brings it into close proximity to the substrate (By similarity). (104 aa) |
| | ube2j2 | Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum; Belongs to the ubiquitin-conjugating enzyme family. (241 aa) |
| | rcbA | UV excision repair protein RAD23 homolog; May play a role both in proteasomal degradation of misfolded proteins and DNA repair; Belongs to the RAD23 family. (342 aa) |
| | dnajc3 | DnaJ homolog subfamily C member 3 homolog; May be involved in the unfolded protein response (UPR) during ER stress. (502 aa) |
| | DDB0229348 | WD-40 repeat-containing protein. (469 aa) |
| | DDB0186819 | J domain-containing protein. (814 aa) |
| | DDB_G0285709 | Heat shock 70-related protein 5; May function in protein folding and assembly, and disassembly of protein complexes. (517 aa) |
| | DDB0186668 | RING-CH-type domain-containing protein. (1088 aa) |
| | ost3 | Probable dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 3; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation acro [...] (351 aa) |
| | DDB0186444 | RING-type domain-containing protein. (281 aa) |
| | stt3 | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3; Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation [...] (714 aa) |
| | derl2 | Probable derlin-2 homolog; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Belongs to the derlin family. (254 aa) |
| | DDB0186116 | Fes1 domain-containing protein. (385 aa) |
| | DDB0185990 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (537 aa) |
| | DDB0185989 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (510 aa) |
| | DDB0185987 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (586 aa) |
| | ssr1 | Translocon-associated protein subunit alpha; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins; Belongs to the TRAP-alpha family. (236 aa) |
| | DDB_G0283065 | Probable serine/threonine-protein kinase DDB_G0283065; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (637 aa) |
| | Mbtps1 | Peptidase_S8 domain-containing protein. (1331 aa) |
| | sec23 | Protein transport protein SEC23; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (750 aa) |
| | DDB0218298 | UBIQUITIN_CONJUGAT_2 domain-containing protein. (401 aa) |
| | sec24 | Protein transport protein SEC24; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1013 aa) |
| | DDB0206533 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (125 aa) |
| | ssr2 | Translocon-associated protein subunit beta; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (184 aa) |
| | ddj1 | Heat shock protein. (411 aa) |
| | DDB0206405 | Uncharacterized protein. (868 aa) |
| | Amfr | RING-type domain-containing protein. (679 aa) |
| | culE | Cullin-5; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). (750 aa) |
| | sec61a | Protein transport protein Sec61 subunit alpha; Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). (475 aa) |
| | sarB | GTP-binding protein Sar1B; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (194 aa) |
| | sec61b | Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (61 aa) |
| | sec24l | Uncharacterized protein. (1133 aa) |
| | ifkB | Probable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1358 aa) |
| | DDB0217882 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (632 aa) |
| | Mbtps2 | Peptidase_M50 domain-containing protein. (562 aa) |
| | bip1-1 | Luminal-binding protein 1; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family. (926 aa) |
| | hspE-1 | Heat shock cognate 70 kDa protein 2; May function in protein folding and assembly, and disassembly of protein complexes. (632 aa) |
| | fpaB-1 | SCF ubiquitin ligase complex protein SKP1b(4-162). (162 aa) |
| | ifkA | Probable serine/threonine-protein kinase ifkA; Phosphorylates eIF2-alpha, from 1 to 7 hours after the onset of development or during the preaggregation state, resulting in a shift from polysomes to free ribosomes for bulk mRNA. (2258 aa) |
| | sarA | GTP-binding protein Sar1A; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (188 aa) |
| | cnxA | Uncharacterized protein. (536 aa) |
| | yod1 | Ubiquitin thioesterase OTU1; Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. (325 aa) |
| | ufd1 | Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family. (330 aa) |
| | DDB_G0271120 | Uncharacterized protein. (524 aa) |
| | sec31 | Protein transport protein SEC31; Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity). (1355 aa) |
| | DDB0190008 | alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (655 aa) |
| | DDB_G0268642 | Probable serine/threonine-protein kinase DDB_G0268642; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1078 aa) |
| | DDB0189828 | TGc domain-containing protein. (618 aa) |
| | ireA | Probable serine/threonine-protein kinase ireA. (984 aa) |
| | ssr3 | Translocon-associated protein subunit gamma; TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. (170 aa) |
| | DDB0168503 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (171 aa) |
| | ifkC | Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1700 aa) |
| | eif2s1 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] (341 aa) |
| | DDB_G0275025 | Putative protein disulfide-isomerase DDB_G0275025; Belongs to the protein disulfide isomerase family. (409 aa) |
| | DDB0168975 | Uncharacterized protein. (738 aa) |
| | pdi1 | Protein disulfide-isomerase 1; Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. (363 aa) |
| | ggtA | Probable UDP-glucose:glycoprotein glucosyltransferase A; Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum (By similarity); Belongs to the glycosyltransferase 8 family. (1681 aa) |
| | DDB0168584 | L-type lectin-like domain-containing protein. (569 aa) |
| | bip2 | Luminal-binding protein 2; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family. (658 aa) |
| | modA | Neutral alpha-glucosidase AB; Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from N-linked oligosaccharides on newly synthesized glycoproteins. (943 aa) |
| | ubqln | Ubiquilin; Stable protein which acts as an antagonist of nosA by repressing cellular differentiation after the tight-aggregate stage, when cells differentiate into two precursor cell types, prespore and prestalk cells, prior to the formation of fruiting bodies. (523 aa) |
| | grp94 | Endoplasmin homolog; May play a role in late differentiation as well as in starvation response. When overexpressed, suppresses the ability to form normal fruiting bodies and impairs prespore differentiation as well as maturation into spores; Belongs to the heat shock protein 90 family. (768 aa) |
| | culB | Cullin-2; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Appears to ensure that the proper number of prestalk cells differentiate at the appropriate time in development. May govern prestalk cell differentiation. (771 aa) |
