114 items (Histoplasma capsulatum G186AR) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCBG_06948	C-14 sterol reductase. (503 aa)
	HCBG_00102	INSIG domain-containing protein. (440 aa)
	HCBG_00120	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (488 aa)
	HCBG_00189	Polyphenoloxidase. (638 aa)
	HCBG_00405	Cytochrome P450 sterol 14 alpha-demethylase; Belongs to the cytochrome P450 family. (515 aa)
	HCBG_00414	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1160 aa)
	HCBG_00653	Uncharacterized protein. (183 aa)
	HCBG_00668	Pyridoxine kinase. (406 aa)
	HCBG_00778	Uncharacterized protein; Belongs to the cytochrome P450 family. (554 aa)
	HCBG_00791	NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (321 aa)
	HCBG_00945	DJ-1/PfpI family protein. (227 aa)
	HCBG_01021	F-box domain-containing protein. (621 aa)
	HCBG_01142	Zn(2)-C6 fungal-type domain-containing protein. (758 aa)
	HCBG_02044	Squalene epoxidase. (484 aa)
	HCBG_02092	Pyridoxine biosynthesis protein pyroA; Belongs to the PdxS/SNZ family. (320 aa)
	HCBG_02128	Uncharacterized protein. (312 aa)
	HCBG_01424	Uncharacterized protein. (487 aa)
	HCBG_01619	Uncharacterized protein. (494 aa)
	HCBG_01624	Enoyl-CoA hydratase. (149 aa)
	HCBG_01654	Pyruvate decarboxylase. (592 aa)
	HCBG_01659	Uracil-5-carboxylate decarboxylase; Belongs to the metallo-dependent hydrolases superfamily. (381 aa)
	HCBG_01818	7-dehydrosterol-delta 7-reductase. (426 aa)
	HCBG_02452	Neutral ceramidase. (764 aa)
	HCBG_02560	PH domain-containing protein. (1467 aa)
	HCBG_02598	5-oxoprolinase. (1312 aa)
	HCBG_02656	Serine palmitoyltransferase. (507 aa)
	HCBG_02675	C-3 sterol dehydrogenase/C-4 decarboxylase. (355 aa)
	HCBG_02756	Tyrosinase. (801 aa)
	HCBG_02788	Glycosyltransferase. (1340 aa)
	HCBG_03090	Alcohol dehydrogenase. (495 aa)
	HCBG_02204	5-oxoprolinase. (516 aa)
	HCBG_02205	5-oxoprolinase. (465 aa)
	HCBG_02341	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (406 aa)
	HCBG_03121	Uncharacterized protein. (308 aa)
	HCBG_03155	N-acetyltransferase domain-containing protein. (219 aa)
	HCBG_03399	3-ketosteroid reductase. (472 aa)
	HCBG_03424	Dehydrodolichyl diphosphate synthetase. (412 aa)
	HCBG_03542	C-24(28) sterol reductase. (472 aa)
	HCBG_03591	DUF2236 domain-containing protein. (425 aa)
	HCBG_03602	Sterol desaturase; Belongs to the sterol desaturase family. (334 aa)
	HCBG_03608	Sphingosine kinase. (508 aa)
	HCBG_03737	Uncharacterized protein. (387 aa)
	HCBG_03808	EXPERA domain-containing protein. (231 aa)
	HCBG_03871	Uncharacterized protein. (116 aa)
	HCBG_04301	Ergosterol biosynthetic protein. (133 aa)
	HCBG_04384	Inositol-3-phosphate synthase. (532 aa)
	HCBG_04487	N-acetyltransferase domain-containing protein. (208 aa)
	HCBG_04523	Thiamine-phosphate pyrophosphorylase. (520 aa)
	HCBG_04562	Glutamine amidotransferase subunit pdxT. (279 aa)
	HCBG_03987	FAD binding domain-containing protein. (514 aa)
	HCBG_04064	ThiJ/PfpI family protein. (232 aa)
	HCBG_04066	AB hydrolase-1 domain-containing protein. (499 aa)
	HCBG_04177	Enoyl-CoA hydratase. (275 aa)
	HCBG_04208	DUF2236 domain-containing protein. (361 aa)
	HCBG_04235	Sterol desaturase; Belongs to the sterol desaturase family. (263 aa)
	HCBG_04794	Acetyl-coa acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (241 aa)
	HCBG_04835	Kinase; Belongs to the inositol phosphokinase (IPK) family. (457 aa)
	HCBG_04898	Pyridox_oxase_2 domain-containing protein. (192 aa)
	HCBG_04899	Uncharacterized protein. (375 aa)
	HCBG_04936	Pyridoxamine 5'-phosphate oxidase. (396 aa)
	HCBG_04940	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (542 aa)
	HCBG_05053	Pkinase_fungal domain-containing protein. (365 aa)
	cprA	NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (694 aa)
	HCBG_05244	C-8 sterol isomerase. (223 aa)
	HCBG_05712	Thiamine biosynthesis protein. (343 aa)
	HCBG_05624	Uncharacterized protein; Belongs to the cytochrome P450 family. (508 aa)
	HCBG_05924	BZIP domain-containing protein. (554 aa)
	HCBG_05943	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (137 aa)
	HCBG_06083	Thiamine thiazole synthase; Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5- (2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron- dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance; Belongs to the T [...] (334 aa)
	HCBG_06193	Cytochrome P450 sterol C-22 desaturase; Belongs to the cytochrome P450 family. (533 aa)
	HCBG_06307	5-oxoprolinase. (1360 aa)
	HCBG_06316	Kinase; Belongs to the inositol phosphokinase (IPK) family. (1572 aa)
	HCBG_06319	Uncharacterized protein. (793 aa)
	HCBG_06458	GTP cyclohydrolase I. (390 aa)
	HCBG_06474	ThiJ/PfpI family protein. (258 aa)
	HCBG_06540	Isopenicillin N-CoA epimerase. (398 aa)
	HCBG_06620	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (322 aa)
	HCBG_06981	Uncharacterized protein. (148 aa)
	HCBG_07008	Uncharacterized protein. (161 aa)
	HCBG_06694	Pyruvate decarboxylase. (546 aa)
	HCBG_06726	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (475 aa)
	HCBG_07213	AB hydrolase-1 domain-containing protein. (413 aa)
	HCBG_07329	Squalene synthetase. (493 aa)
	HCBG_07384	Macrophage binding protein. (244 aa)
	HCBG_07439	Scytalone dehydratase. (162 aa)
	HCBG_07495	Uncharacterized protein. (77 aa)
	HCBG_07507	Acetyltransferase. (207 aa)
	HCBG_07543	FAD binding domain-containing protein. (575 aa)
	HCBG_07564	2-nitropropane dioxygenase. (376 aa)
	HCBG_07597	Uncharacterized protein. (332 aa)
	HCBG_07601	N-acetyltransferase domain-containing protein. (184 aa)
	HCBG_07604	3-dehydroshikimate dehydratase. (277 aa)
	HCBG_08099	Phosphomethylpyrimidine kinase THI20. (488 aa)
	HCBG_08154	Photo-regulated tyrosinase. (797 aa)
	HCBG_07850	Inositol-pentakisphosphate 2-kinase; Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). (377 aa)
	HCBG_07898	Delta(24(24(1)))-sterol reductase. (552 aa)
	HCBG_08275	Enoyl-CoA hydratase. (240 aa)
	HCBG_08346	C-4 methylsterol oxidase; Belongs to the sterol desaturase family. (259 aa)
	HCBG_08349	Uncharacterized protein. (279 aa)
	HCBG_08351	Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase; Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates [...] (1501 aa)
	HCBG_08417	Sterol 24-C-methyltransferase; Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. (380 aa)
	HCBG_08505	Sucrase/ferredoxin domain-containing protein. (344 aa)
	HCBG_08645	Sucrose cleavage family protein. (369 aa)
	HCBG_08852	Cytochrome P450; Belongs to the cytochrome P450 family. (505 aa)
	HCBG_08973	AMP dependent synthetase and ligase. (547 aa)
	HCBG_09033	Nonribosomal peptide synthetase. (1955 aa)
	HCBG_09040	Long-chain-fatty-acid-CoA ligase. (589 aa)
	HCBG_09041	Acetylase. (439 aa)
	HCBG_09059	C-3 sterol dehydrogenase/C-4 decarboxylase. (426 aa)
	HCBG_09081	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family. (1260 aa)
	HCBG_09106	Uncharacterized protein; Belongs to the cytochrome P450 family. (544 aa)
	HCBG_09147	C-5 sterol desaturase; Belongs to the sterol desaturase family. (356 aa)
	HCBG_09179	FAD-binding FR-type domain-containing protein. (396 aa)
	HCBG_09220	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (239 aa)

Your Current Organism:

Histoplasma capsulatum G186AR

NCBI taxonomy Id: 447093
Other names: Ajellomyces capsulatus G186AR, H. capsulatum G186AR

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCBG_00102	HCBG_00405	C0NAF6	C0NBA9	INSIG domain-containing protein.	Cytochrome P450 sterol 14 alpha-demethylase; Belongs to the cytochrome P450 family.	0.472
HCBG_00102	HCBG_00414	C0NAF6	C0NBB8	INSIG domain-containing protein.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.926
HCBG_00102	HCBG_09081	C0NAF6	C0P101	INSIG domain-containing protein.	Lanosterol 14-alpha-demethylase; Belongs to the cytochrome P450 family.	0.472
HCBG_00102	HCBG_09147	C0NAF6	C0P167	INSIG domain-containing protein.	C-5 sterol desaturase; Belongs to the sterol desaturase family.	0.409
HCBG_00120	HCBG_00405	C0NAH4	C0NBA9	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Cytochrome P450 sterol 14 alpha-demethylase; Belongs to the cytochrome P450 family.	0.405
HCBG_00120	HCBG_00414	C0NAH4	C0NBB8	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.973
HCBG_00120	HCBG_01624	C0NAH4	C0NFF8	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Enoyl-CoA hydratase.	0.464
HCBG_00120	HCBG_01818	C0NAH4	C0NG02	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	7-dehydrosterol-delta 7-reductase.	0.413
HCBG_00120	HCBG_02044	C0NAH4	C0NDV1	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Squalene epoxidase.	0.636
HCBG_00120	HCBG_02341	C0NAH4	C0NIT4	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.991
HCBG_00120	HCBG_02656	C0NAH4	C0NH34	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Serine palmitoyltransferase.	0.499
HCBG_00120	HCBG_02675	C0NAH4	C0NH53	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	C-3 sterol dehydrogenase/C-4 decarboxylase.	0.433
HCBG_00120	HCBG_03399	C0NAH4	C0NJR9	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-ketosteroid reductase.	0.665
HCBG_00120	HCBG_03808	C0NAH4	C0NKX8	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	EXPERA domain-containing protein.	0.422
HCBG_00120	HCBG_04177	C0NAH4	C0NN50	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Enoyl-CoA hydratase.	0.464
HCBG_00120	HCBG_04794	C0NAH4	C0NNR4	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Acetyl-coa acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.807
HCBG_00120	HCBG_04940	C0NAH4	C0NP60	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.960
HCBG_00120	HCBG_05244	C0NAH4	C0NQ14	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	C-8 sterol isomerase.	0.475
HCBG_00120	HCBG_06193	C0NAH4	C0NSR3	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	Cytochrome P450 sterol C-22 desaturase; Belongs to the cytochrome P450 family.	0.459
HCBG_00120	HCBG_06726	C0NAH4	C0NUW2	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.912