47 items (Histoplasma capsulatum G186AR) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HCBG_03100	Zds_C domain-containing protein. (870 aa)
	HCBG_02832	Checkpoint protein; Belongs to the HUS1 family. (364 aa)
	HCBG_02745	Serine/threonine-protein kinase chk1. (468 aa)
	HCBG_01632	Uncharacterized protein. (117 aa)
	HCBG_01370	DNA replication initiation factor Cdc45. (865 aa)
	HCBG_02094	Origin recognition complex subunit. (556 aa)
	HCBG_01017	AAA domain-containing protein. (608 aa)
	HCBG_00873	DNA helicase; Belongs to the MCM family. (1017 aa)
	HCBG_00597	Cyclin-dependent protein kinase PhoA; Belongs to the protein kinase superfamily. (399 aa)
	HCBG_00381	CCHC-type domain-containing protein. (313 aa)
	HCBG_00239	Cyclin-dependent protein kinase PhoA; Belongs to the protein kinase superfamily. (310 aa)
	HCBG_00146	AAA domain-containing protein. (394 aa)
	HCBG_09185	Uncharacterized protein. (168 aa)
	HCBG_09174	AAA domain-containing protein. (354 aa)
	HCBG_08826	AAA_16 domain-containing protein. (570 aa)
	HCBG_08537	MRC1 domain-containing protein. (1498 aa)
	HCBG_08331	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2465 aa)
	HCBG_08179	Origin recognition complex subunit. (757 aa)
	HCBG_08105	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (450 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (811 aa)
	HCBG_06030	Cyclin-dependent protein kinase; Belongs to the protein kinase superfamily. (324 aa)
	HCBG_06061	M-phase inducer phosphatase. (537 aa)
	HCBG_06190	DNA helicase; Belongs to the MCM family. (887 aa)
	HCBG_06389	DNA helicase; Belongs to the MCM family. (706 aa)
	HCBG_06849	Cell division cycle protein. (803 aa)
	HCBG_06870	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (415 aa)
	HCBG_05293	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (606 aa)
	HCBG_05803	AAA domain-containing protein. (424 aa)
	HCBG_05834	Uncharacterized protein. (448 aa)
	HCBG_04129	Uncharacterized protein. (77 aa)
	HCBG_04188	TPR domain-containing protein. (445 aa)
	HCBG_05986	G1/S regulator. (676 aa)
	HCBG_07595	Cell division control protein; Belongs to the CDC6/cdc18 family. (619 aa)
	HCBG_07367	Uncharacterized protein. (142 aa)
	HCBG_04807	Origin recognition complex subunit. (686 aa)
	HCBG_04916	DNA helicase; Belongs to the MCM family. (965 aa)
	HCBG_05109	Single-stranded DNA binding protein p30 subunit. (276 aa)
	HCBG_05136	DNA helicase; Belongs to the MCM family. (882 aa)
	HCBG_05152	Chromo domain-containing protein. (414 aa)
	HCBG_04128	Uncharacterized protein. (401 aa)
	HCBG_03936	UDP-galactopyranose mutase. (533 aa)
	HCBG_03804	Uncharacterized protein. (160 aa)
	HCBG_03715	Cell cycle control protein. (967 aa)
	HCBG_03554	Uncharacterized protein. (320 aa)
	HCBG_03381	Uncharacterized protein. (608 aa)
	HCBG_03194	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (836 aa)
	HCBG_03112	Serine/threonine-protein kinase Hsk1. (501 aa)

Your Current Organism:

Histoplasma capsulatum G186AR

NCBI taxonomy Id: 447093
Other names: Ajellomyces capsulatus G186AR, H. capsulatum G186AR

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCBG_00146	HCBG_00873	C0NAK0	C0NCM7	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.878
HCBG_00146	HCBG_01017	C0NAK0	C0ND21	AAA domain-containing protein.	AAA domain-containing protein.	0.999
HCBG_00146	HCBG_01370	C0NAK0	C0NEQ4	AAA domain-containing protein.	DNA replication initiation factor Cdc45.	0.702
HCBG_00146	HCBG_02745	C0NAK0	C0NHC3	AAA domain-containing protein.	Serine/threonine-protein kinase chk1.	0.877
HCBG_00146	HCBG_02832	C0NAK0	C0NHL0	AAA domain-containing protein.	Checkpoint protein; Belongs to the HUS1 family.	0.993
HCBG_00146	HCBG_03112	C0NAK0	C0NIY2	AAA domain-containing protein.	Serine/threonine-protein kinase Hsk1.	0.577
HCBG_00146	HCBG_03194	C0NAK0	C0NJ64	AAA domain-containing protein.	Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.	0.561
HCBG_00146	HCBG_03715	C0NAK0	C0NKN5	AAA domain-containing protein.	Cell cycle control protein.	0.999
HCBG_00146	HCBG_04128	C0NAK0	C0NN01	AAA domain-containing protein.	Uncharacterized protein.	0.972
HCBG_00146	HCBG_04129	C0NAK0	C0NN02	AAA domain-containing protein.	Uncharacterized protein.	0.972
HCBG_00146	HCBG_04916	C0NAK0	C0NP36	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.930
HCBG_00146	HCBG_05109	C0NAK0	C0NPM9	AAA domain-containing protein.	Single-stranded DNA binding protein p30 subunit.	0.955
HCBG_00146	HCBG_05136	C0NAK0	C0NPQ6	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.917
HCBG_00146	HCBG_05293	C0NAK0	C0NQL3	AAA domain-containing protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.884
HCBG_00146	HCBG_05803	C0NAK0	C0NRM3	AAA domain-containing protein.	AAA domain-containing protein.	0.999
HCBG_00146	HCBG_06190	C0NAK0	C0NSR0	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.936
HCBG_00146	HCBG_06389	C0NAK0	C0NTA9	AAA domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.917
HCBG_00146	HCBG_06849	C0NAK0	C0NU18	AAA domain-containing protein.	Cell division cycle protein.	0.420
HCBG_00146	HCBG_07595	C0NAK0	C0NWR5	AAA domain-containing protein.	Cell division control protein; Belongs to the CDC6/cdc18 family.	0.797
HCBG_00146	HCBG_08105	C0NAK0	C0NXB3	AAA domain-containing protein.	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.	0.993