STRINGSTRING
pyrF pyrF surE surE thyA thyA tdk tdk OCK44465.1 OCK44465.1 OCK43352.1 OCK43352.1 OCK43370.1 OCK43370.1 OCK43439.1 OCK43439.1 OCK43521.1 OCK43521.1 OCK43522.1 OCK43522.1 OCK43530.1 OCK43530.1 dut dut OCK43705.1 OCK43705.1 OCK43720.1 OCK43720.1 tadA tadA OCK43837.1 OCK43837.1 OCK44495.1 OCK44495.1 OCK43880.1 OCK43880.1 pyrH pyrH OCK44033.1 OCK44033.1 groS groS OCK44196.1 OCK44196.1 carA carA OCK44307.1 OCK44307.1 ndk ndk OCK44359.1 OCK44359.1 OCK44366.1 OCK44366.1 OCK44406.1 OCK44406.1 OCK44430.1 OCK44430.1 OCK42857.1 OCK42857.1 OCK42934.1 OCK42934.1 OCK42978.1 OCK42978.1 OCK43125.1 OCK43125.1 OCK43066.1 OCK43066.1 tgt tgt OCK42585.1 OCK42585.1 OCK42142.1 OCK42142.1 OCK42177.1 OCK42177.1 OCK42199.1 OCK42199.1 pyrD pyrD OCK41997.1 OCK41997.1 pyrE pyrE pyrB pyrB OCK42069.1 OCK42069.1 OCK42097.1 OCK42097.1 pyrG pyrG OCK41959.1 OCK41959.1 cmk cmk
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (270 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (256 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (274 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
OCK44465.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
OCK43352.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (654 aa)
OCK43370.1Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
OCK43439.1Uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
OCK43521.1Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (799 aa)
OCK43522.1Ribonucleoside-diphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
OCK43530.1NAD(P)-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (251 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (143 aa)
OCK43705.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
OCK43720.1Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa)
tadAtRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (150 aa)
OCK43837.1Peptidoglycan-binding protein LysM; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
OCK44495.1CMP deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
OCK43880.1Restriction endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (1150 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (235 aa)
OCK44033.1Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (91 aa)
OCK44196.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (281 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (371 aa)
OCK44307.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (245 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (139 aa)
OCK44359.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (105 aa)
OCK44366.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (110 aa)
OCK44406.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (185 aa)
OCK44430.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
OCK42857.1Restriction endonuclease subunit R; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
OCK42934.1S1/P1 Nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
OCK42978.1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (236 aa)
OCK43125.1Uridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
OCK43066.1Cytidine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
tgttRNA guanosine(34) transglycosylase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (376 aa)
OCK42585.1Phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
OCK42142.1Phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
OCK42177.1MFS transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
OCK42199.1Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 5'-nucleotidase family. (516 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (344 aa)
OCK41997.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (216 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (310 aa)
OCK42069.1PyrR protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
OCK42097.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (537 aa)
OCK41959.1Carbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (951 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
Your Current Organism:
Tenacibaculum soleae
NCBI taxonomy Id: 447689
Other names: CECT 7292, NCIMB 14368, T. soleae, Tenacibaculum soleae Pineiro-Vidal et al. 2008, strain LL04 12.1.7
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.