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argD argD sce0063 sce0063 argB1 argB1 leuD leuD leuC1 leuC1 ilvE1 ilvE1 ilvE2 ilvE2 argB2 argB2 ilvB1 ilvB1 sce1736 sce1736 cis1 cis1 lysC1 lysC1 sce2591 sce2591 argJ argJ sce3591 sce3591 ilvB2 ilvB2 ilvN ilvN ilvC ilvC leuA1 leuA1 sce3734 sce3734 leuB1 leuB1 aco aco aspB1 aspB1 leuA2 leuA2 argC argC ilvD2 ilvD2 asd asd icd1 icd1 ilvE3 ilvE3 lysC2 lysC2 leuB2 leuB2 icd2 icd2 ilvG1 ilvG1 acnA acnA leuB3 leuB3 sce8254 sce8254 cis2 cis2 sce8481 sce8481 leuC2 leuC2 ilvG2 ilvG2 sce9261 sce9261
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
argDAcetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (420 aa)
sce0063Putative transcriptional regulator. (431 aa)
argB1ArgB1 protein; High confidence in function and specificity. (444 aa)
leuDIsopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (205 aa)
leuC1Isopropylmalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
ilvE1Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (296 aa)
ilvE2Branched-chain-amino-acid transaminase. (324 aa)
argB2Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (284 aa)
ilvB1Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (585 aa)
sce1736Citrate synthase (EC 2.3.3.1). (429 aa)
cis1Citrate synthase; Family membership; Belongs to the citrate synthase family. (406 aa)
lysC1Aspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (415 aa)
sce2591Putative aminotransferase; Specificity unclear. (422 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (391 aa)
sce3591Amino-acid acetyltransferase; High confidence in function and specificity. (198 aa)
ilvB2Acetolactate synthase; Family membership. (569 aa)
ilvNAcetolactate synthase; Family membership. (182 aa)
ilvCKetol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
leuA12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (564 aa)
sce37342-isopropylmalate synthase; Family membership; Belongs to the alpha-IPM synthase/homocitrate synthase family. (548 aa)
leuB13-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa)
aco3-isopropylmalate dehydratase large subunit; High confidence in function and specificity. (660 aa)
aspB1Aspartate transaminase; Family membership. (399 aa)
leuA22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (563 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (321 aa)
ilvD2Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (638 aa)
asdAsd protein; High confidence in function and specificity; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
icd1Isocitrate dehydrogenase; High confidence in function and specificity. (343 aa)
ilvE3Branched-chain-amino-acid transaminase; High confidence in function and specificity. (372 aa)
lysC2Aspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (426 aa)
leuB23-isopropylmalate dehydrogenase; Family membership. (338 aa)
icd2Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (776 aa)
ilvG1Putative Acetolactate synthase; Family membership; Belongs to the TPP enzyme family. (546 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (917 aa)
leuB33-isopropylmalate dehydrogenase; High confidence in function and specificity. (363 aa)
sce8254Diaminobutyrate--2-oxoglutarate transaminase; Family membership; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (484 aa)
cis2Citrate synthase; High confidence in function and specificity; Belongs to the citrate synthase family. (433 aa)
sce8481Putative 2-isopropylmalate synthase; Family membership; Belongs to the alpha-IPM synthase/homocitrate synthase family. (402 aa)
leuC23-isopropylmalate dehydratase; Family membership. (662 aa)
ilvG2Acetolactate synthase; Family membership; Belongs to the TPP enzyme family. (571 aa)
sce9261Aspartate kinase; Family membership; Belongs to the aspartokinase family. (443 aa)
Your Current Organism:
Sorangium cellulosum So ce56
NCBI taxonomy Id: 448385
Other names: S. cellulosum So ce56, Sorangium cellulosum DSM 53796, Sorangium cellulosum str. So ce56, Sorangium cellulosum strain So ce56
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