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| | argD | Acetylornithine aminotransferase; High confidence in function and specificity; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (420 aa) |
| | tal2 | Probable transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa) |
| | argB1 | ArgB1 protein; High confidence in function and specificity. (444 aa) |
| | argF1 | ArgF1 protein; High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (333 aa) |
| | leuD | Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (205 aa) |
| | leuC1 | Isopropylmalate isomerase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | ilvE1 | Branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (296 aa) |
| | ilvE2 | Branched-chain-amino-acid transaminase. (324 aa) |
| | argB2 | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (284 aa) |
| | thrB | Putative homoserine kinase; Belongs to the pseudomonas-type ThrB family. (358 aa) |
| | hisIE | Histidine biosynthesis bifunctional protein HisIE; Family membership; In the N-terminal section; belongs to the PRA-CH family. (229 aa) |
| | sce0438 | Cystathionine beta-synthase; High confidence in function and specificity. (461 aa) |
| | sce0620 | Probable anthranilate synthase component I; Family membership. (414 aa) |
| | serB | SerB protein; High confidence in function and specificity. (394 aa) |
| | aroB1 | 3-dehydroquinate synthase; Family membership. (436 aa) |
| | pgm1 | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (543 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (348 aa) |
| | trpC | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase; High confidence in function and specificity; Belongs to the TrpC family. (493 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (378 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | ilvB1 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. (585 aa) |
| | sce1220 | Similar to Xaa-His dipeptidase; Family membership. (618 aa) |
| | tal1 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (332 aa) |
| | sce1526 | Putative D-isomer specific 2-hydroxyacid dehydrogenase family protein; Family membership; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa) |
| | aroE1 | Shikimate dehydrogenase (NADP(+)); Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (258 aa) |
| | sce1736 | Citrate synthase (EC 2.3.3.1). (429 aa) |
| | cis1 | Citrate synthase; Family membership; Belongs to the citrate synthase family. (406 aa) |
| | pheA1 | PheA1 protein; Family membership. (364 aa) |
| | rpiA | Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (232 aa) |
| | argH | Argininosuccinate lyase; High confidence in function and specificity. (430 aa) |
| | sdaA | L-serine dehydratase; High confidence in function and specificity; Belongs to the iron-sulfur dependent L-serine dehydratase family. (470 aa) |
| | fba1 | Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (357 aa) |
| | ltaA | LtaA protein; Family membership. (367 aa) |
| | sce2064 | Asparagine synthetase; Family membership. (668 aa) |
| | aroE2 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (274 aa) |
| | pfp | Diphosphate-fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (439 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase; Family membership. (402 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (460 aa) |
| | aroE3 | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (328 aa) |
| | aroG | 3-deoxy-7-phosphoheptulonate synthase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (355 aa) |
| | lysC1 | Aspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (415 aa) |
| | fba2 | Fructose-bisphosphate aldolase; Family membership. (308 aa) |
| | sce2591 | Putative aminotransferase; Specificity unclear. (422 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; High confidence in function and specificity. (241 aa) |
| | hisH | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (225 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase; Specificity unclear. (229 aa) |
| | argJ | Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (391 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; High confidence in function and specificity; Belongs to the transferase hexapeptide repeat family. (291 aa) |
| | dapE2 | Succinyl-diaminopimelate desuccinylase. (367 aa) |
| | sce3029 | Aminotransferase; Family membership. (472 aa) |
| | aroA1 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | asnB1 | Asparagine synthetase; High confidence in function and specificity. (654 aa) |
| | cysK2 | Cysteine synthase A; Family membership; Belongs to the cysteine synthase/cystathionine beta- synthase family. (330 aa) |
| | srpH1 | SrpH1 protein; Family membership. (330 aa) |
| | sce3591 | Amino-acid acetyltransferase; High confidence in function and specificity. (198 aa) |
| | sce3599 | Probable Transaldolase; Family membership. (216 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (426 aa) |
| | sce3685 | 3-deoxy-7-phosphoheptulonate synthase; High confidence in function and specificity. (457 aa) |
| | ilvB2 | Acetolactate synthase; Family membership. (569 aa) |
| | ilvN | Acetolactate synthase; Family membership. (182 aa) |
| | ilvC | Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | leuA1 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (564 aa) |
| | sce3734 | 2-isopropylmalate synthase; Family membership; Belongs to the alpha-IPM synthase/homocitrate synthase family. (548 aa) |
| | leuB1 | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (354 aa) |
| | asnB2 | AsnB2 protein; High confidence in function and specificity. (670 aa) |
| | ilvA | Putative serine/threonine dehydratase; High confidence in function and specificity. (313 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (155 aa) |
| | aco | 3-isopropylmalate dehydratase large subunit; High confidence in function and specificity. (660 aa) |
| | glnA1 | GlnA1 protein; Family membership; Belongs to the glutamine synthetase family. (453 aa) |
| | tkt1 | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa) |
| | serA1 | Phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (419 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase; Family membership; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | aspB1 | Aspartate transaminase; Family membership. (399 aa) |
| | pgm2 | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the BPG-independent phosphoglycerate mutase family. (552 aa) |
| | pyk | Pyruvate kinase; High confidence in function and specificity; Belongs to the pyruvate kinase family. (475 aa) |
| | srpH2 | SrpH2 protein; Family membership. (324 aa) |
| | cysK3 | Cysteine synthase; High confidence in function and specificity; Belongs to the cysteine synthase/cystathionine beta- synthase family. (329 aa) |
| | cysK4 | Cysteine synthase; High confidence in function and specificity; Belongs to the cysteine synthase/cystathionine beta- synthase family. (296 aa) |
| | aroB2 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (536 aa) |
| | aroC | 5-enolpyruvylshikimate-3-phosphate phospholyase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (394 aa) |
| | hom | Homoserine dehydrogenase; High confidence in function and specificity. (468 aa) |
| | leuA2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (563 aa) |
| | asnH | AsnH protein; High confidence in function and specificity. (616 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (321 aa) |
| | trpE | Anthranilate synthase; High confidence in function and specificity. (717 aa) |
| | argG | Argininosuccinate synthase; High confidence in function and specificity; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (450 aa) |
| | gltB1 | Glutamate synthase (NADPH); High confidence in function and specificity. (1535 aa) |
| | gltD | Glutamate synthase (NADPH); High confidence in function and specificity. (479 aa) |
| | sce5074 | Putative serineacetyltransferase. (185 aa) |
| | sce5197 | Put. Pyruvate kinase; Family membership; Belongs to the pyruvate kinase family. (500 aa) |
| | phhA | Phenylalanine 4-monooxygenase; Family membership. (288 aa) |
| | ilvD2 | Dihydroxy-acid dehydratase; High confidence in function and specificity; Belongs to the IlvD/Edd family. (638 aa) |
| | asd | Asd protein; High confidence in function and specificity; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | lysA-2 | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (435 aa) |
| | cysK5 | CysK5 protein; High confidence in function and specificity. (316 aa) |
| | cysK6 | CysK6 protein; Family membership. (353 aa) |
| | icd1 | Isocitrate dehydrogenase; High confidence in function and specificity. (343 aa) |
| | serA2 | D-3-phosphoglycerate dehydrogenase; Family membership; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (402 aa) |
| | pfk | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (389 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (285 aa) |
| | metH1 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1259 aa) |
| | hisF | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (270 aa) |
| | ilvE3 | Branched-chain-amino-acid transaminase; High confidence in function and specificity. (372 aa) |
| | metB1 | Cystathionine gamma-synthase; Family membership. (396 aa) |
| | lysC2 | Aspartate kinase; High confidence in function and specificity; Belongs to the aspartokinase family. (426 aa) |
| | dapE3 | Succinyl-diaminopimelate desuccinylase; Family membership. (350 aa) |
| | leuB2 | 3-isopropylmalate dehydrogenase; Family membership. (338 aa) |
| | prsA1 | Putative Ribose-phosphate diphosphokinase; Family membership; Belongs to the ribose-phosphate pyrophosphokinase family. (307 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (423 aa) |
| | icd2 | Isocitrate dehydrogenase; Belongs to the monomeric-type IDH family. (776 aa) |
| | aroA2 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (461 aa) |
| | prsA2 | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (314 aa) |
| | lysA | LysA protein; Family membership; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (427 aa) |
| | pheA2 | P-protein (prephenate dehydratase / chorismate mutase); Family membership. (305 aa) |
| | argF2 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (311 aa) |
| | glnA2 | Glutamate--ammonia ligase; High confidence in function and specificity. (470 aa) |
| | metK | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (422 aa) |
| | sce7326 | O-acetyltransferase; Family membership. (154 aa) |
| | tpi | Triose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (277 aa) |
| | pgk | Phosphoglycerate kinase; High confidence in function and specificity; Belongs to the phosphoglycerate kinase family. (411 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating); High confidence in function and specificity; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa) |
| | cysK7 | Cysteine synthase; High confidence in function and specificity; Belongs to the cysteine synthase/cystathionine beta- synthase family. (318 aa) |
| | metB2 | Cystathionine gamma-synthase. (398 aa) |
| | eno | Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | metH2 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1281 aa) |
| | pheA3 | Chorismate mutase; High confidence in function and specificity. (359 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (275 aa) |
| | ilvG1 | Putative Acetolactate synthase; Family membership; Belongs to the TPP enzyme family. (546 aa) |
| | acnA | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (917 aa) |
| | leuB3 | 3-isopropylmalate dehydrogenase; High confidence in function and specificity. (363 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (265 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Family membership; Belongs to the ribulose-phosphate 3-epimerase family. (237 aa) |
| | sce8223 | Hypothetical protein. (408 aa) |
| | sce8254 | Diaminobutyrate--2-oxoglutarate transaminase; Family membership; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (484 aa) |
| | cis2 | Citrate synthase; High confidence in function and specificity; Belongs to the citrate synthase family. (433 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (387 aa) |
| | tkt2 | Tkt2 protein; High confidence in function and specificity. (570 aa) |
| | sce8481 | Putative 2-isopropylmalate synthase; Family membership; Belongs to the alpha-IPM synthase/homocitrate synthase family. (402 aa) |
| | sce8634 | Methylenetetrahydrofolate reductase family protein; Family membership. (624 aa) |
| | leuC2 | 3-isopropylmalate dehydratase; Family membership. (662 aa) |
| | ilvG2 | Acetolactate synthase; Family membership; Belongs to the TPP enzyme family. (571 aa) |
| | cysB | Cystathionine beta-synthase; High confidence in function and specificity. (466 aa) |
| | asnB3 | AsnB3 protein; Family membership. (601 aa) |
| | hisC3 | Histidinol-phosphate transaminase; Family membership; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (431 aa) |
| | hisC4 | Histidinol-phosphate transaminase; High confidence in function and specificity; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (360 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (211 aa) |
| | thrC | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (446 aa) |
| | sce9228 | Inositol monophosphatase family protein; Family membership. (265 aa) |
| | sce9261 | Aspartate kinase; Family membership; Belongs to the aspartokinase family. (443 aa) |
