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korB korB korA korA etfA etfA etfB etfB dsbD dsbD LHA_2380 LHA_2380 LHA_2437 LHA_2437 LHA_2485 LHA_2485 cydA-2 cydA-2 LHA_3258 LHA_3258 nuoA nuoA nuoB nuoB nuoC nuoC nuoD nuoD LHA_2990 LHA_2990 nuoF nuoF nuoG nuoG nuoJ nuoJ nuoK nuoK nuoL nuoL nuoM nuoM cydA cydA LHA_0930 LHA_0930 LHA_1011 LHA_1011 cyoC cyoC cyoB cyoB cyoA cyoA LHA_1416 LHA_1416 LHA_1456 LHA_1456 cybB cybB rubA rubA LHA_0107 LHA_0107 cycA cycA coxB coxB ctaD ctaD mt:CoIII mt:CoIII LHA_0180 LHA_0180 azoR azoR wrbA wrbA etfdh etfdh cc cc LHA_0412 LHA_0412 LHA_0912 LHA_0912 nuoN nuoN sdhC sdhC sdhA sdhA sdhB sdhB wrbA-2 wrbA-2 LHA_2764 LHA_2764 dsbB dsbB petA petA petB petB petC petC qxtB qxtB LHA_2117 LHA_2117
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
korB2-oxoglutarate ferredoxin oxidoreductase beta subunit. (324 aa)
korA2-oxoglutarate synthase subunit korA; Function of strongly homologous gene; enzyme. (602 aa)
etfAElectron transfer flavoprotein subunit alpha. (313 aa)
etfBElectron transfer flavoprotein subunit beta. (249 aa)
dsbDThiol:disulfide interchange protein DsbD; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (603 aa)
LHA_2380Protein-disulfide reductase; Function of strongly homologous gene; enzyme. (452 aa)
LHA_2437Cytochrome b561 transmembrane protein. (176 aa)
LHA_2485Putative NADH-ubiquinone oxidoreductase chain 5; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (499 aa)
cydA-2Cytochrome D ubiquinol oxidase subunit I. (456 aa)
LHA_3258Exported protein of unknown function; No homology to any previously reported sequences. (112 aa)
nuoANADH-quinone oxidoreductase subunit A; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. (119 aa)
nuoBNADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (158 aa)
nuoCNADH-quinone oxidoreductase subunit C; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 30 kDa subunit family. (228 aa)
nuoDNADH-quinone oxidoreductase subunit D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I 49 kDa subunit family. (417 aa)
LHA_2990NADH dehydrogenase I, E subunit. (167 aa)
nuoFNADH-quinone oxidoreductase subunit F; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (425 aa)
nuoGNADH-quinone oxidoreductase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (782 aa)
nuoJNADH dehydrogenase I, J subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (213 aa)
nuoKNADH-quinone oxidoreductase subunit K; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 4L family. (101 aa)
nuoLNADH-quinone oxidoreductase subunit L. (657 aa)
nuoMNADH-quinone oxidoreductase subunit M. (501 aa)
cydACytochrome d ubiquinol oxidase subunit 1. (509 aa)
LHA_0930Ferredoxin 1; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (111 aa)
LHA_1011Homologs of previously reported genes of unknown function. (122 aa)
cyoCCytochrome o ubiquinol oxidase subunit 3. (198 aa)
cyoBUbiquinol oxidase subunit 1; Belongs to the heme-copper respiratory oxidase family. (664 aa)
cyoAUbiquinol oxidase subunit 2. (315 aa)
LHA_1416Homologs of previously reported genes of unknown function. (135 aa)
LHA_1456Exported protein of unknown function; No homology to any previously reported sequences. (263 aa)
cybBCybB cytochrome b-561 transmembrane protein. (191 aa)
rubARubredoxin-1. (58 aa)
LHA_0107Exported protein of unknown function; No homology to any previously reported sequences. (490 aa)
cycAFunction of strongly homologous gene; enzyme. (616 aa)
coxBCytochrome c oxidase subunit 2; Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). (403 aa)
ctaDPutative cytochrome c oxidase subunit 1; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (535 aa)
mt:CoIIICytochrome c oxidase subunit 3. (289 aa)
LHA_0180Iron-sulfur cluster binding protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (203 aa)
azoRFMN-dependent NADH-azoreductase; Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity; Belongs to the azoreductase type 1 family. (205 aa)
wrbAPutative conserved flavoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (199 aa)
etfdhElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial; Accepts electrons from ETF and reduces ubiquinone. (543 aa)
ccCytochrome c4. (199 aa)
LHA_0412Putative cytochrome c; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (394 aa)
LHA_0912Putative cytochrome oxidase subunit 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (378 aa)
nuoNNADH-quinone oxidoreductase subunit N; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 2 family. (479 aa)
sdhCSuccinate dehydrogenase cytochrome b556 subunit. (128 aa)
sdhASuccinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit. (240 aa)
wrbA-2Flavoprotein wrbA; Belongs to the WrbA family. (201 aa)
LHA_2764Homologs of previously reported genes of unknown function. (144 aa)
dsbBDisulfide bond formation protein B; Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family. (169 aa)
petAUbiquinol-cytochrome c reductase iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (214 aa)
petBCytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (403 aa)
petCCytochrome c1. (249 aa)
qxtBCytochrome d ubiquinol oxidase subunit 2; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (329 aa)
LHA_2117Homologs of previously reported genes of unknown function. (229 aa)
Your Current Organism:
Legionella hackeliae
NCBI taxonomy Id: 449
Other names: ATCC 35250, CCUG 31232, CCUG 31232 A, CIP 103844, DSM 19214, JCM 7563, L. hackeliae, NCTC 11979, strain Lansing 2
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