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| | DWF | 7-dehydrocholesterol reductase. (430 aa) |
| | wrbA | Putative conserved flavoprotein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative regulator. (199 aa) |
| | coq | 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6- methoxy-1,4-benzoquinol during ubiquinone biosynthesis. (213 aa) |
| | aatA | Aspartate aminotransferase A. (392 aa) |
| | ubiH | 2-octaprenyl-6-methoxyphenol hydroxylase. (400 aa) |
| | LHA_0063 | 2-polyprenyl-6-methoxyphenol hydroxylase. (390 aa) |
| | yrbE | Uncharacterized oxidoreductase yrbE. (338 aa) |
| | ubiE | Ubiquinone/menaquinone biosynthesis methyltransferase ubiE; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). (250 aa) |
| | LHA_0133 | Putative 2-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (337 aa) |
| | LHA_0145 | L-asparaginase II; Function of strongly homologous gene; enzyme. (330 aa) |
| | ansA | L-asparaginase 1. (336 aa) |
| | gcvPB | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (483 aa) |
| | gcvPA | Putative glycine dehydrogenase [decarboxylating] subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (456 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | gcvT | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | LHA_0250 | Homologs of previously reported genes of unknown function. (276 aa) |
| | hss | Homospermidine synthase. (469 aa) |
| | tktA | Transketolase 1; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | epd | D-erythrose 4-phosphate dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (330 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (395 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (243 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (622 aa) |
| | LHA_0373 | Acyl carrier protein. (135 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (135 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (277 aa) |
| | hss-2 | Homospermidine synthase. (470 aa) |
| | argH | Argininosuccinate lyase. (414 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | LHA_0442 | Acetolactate synthase; Belongs to the TPP enzyme family. (552 aa) |
| | algC | Phosphomannomutase/phosphoglucomutase. (462 aa) |
| | LHA_0499 | Putative 2-aminoadipate transaminase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (395 aa) |
| | LHA_0501 | Putative Hydroxyacid oxidase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (359 aa) |
| | plsY | Glycerol-3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (255 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa) |
| | purH | Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase]. (530 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (157 aa) |
| | aroQ | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa) |
| | FBA | Putative fructose-bisphosphate aldolase 2, chloroplastic; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (336 aa) |
| | pssA | CDP-diacylglycerol-serine-O- phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (252 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (516 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (244 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (265 aa) |
| | ispB | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. (322 aa) |
| | LHA_0635 | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. (296 aa) |
| | hprA | Glycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (320 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa) |
| | aro | Phospho-2-dehydro-3-deoxyheptonate aldolase. (444 aa) |
| | metK | S-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (382 aa) |
| | LHA_0685 | Putative Phosphoribosylaminoimidazole carboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (393 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (259 aa) |
| | fabI | Enoyl-[acyl-carrier-protein] reductase [NADH]. (261 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (352 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | LHA_0730 | HAD superfamily hydrolase. (223 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase [NAD(P)+]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (329 aa) |
| | hmgcll | Putative 3-hydroxymethyl-3-methylglutaryl-CoA lyase 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (301 aa) |
| | phbA | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (420 aa) |
| | LHA_0914 | Acetyl-CoA acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (424 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (289 aa) |
| | pheA | P-protein [Includes: Chorismate mutase; Prephenate dehydratase]. (359 aa) |
| | pfp | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (411 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (471 aa) |
| | yjjG | dUMP phosphatase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (232 aa) |
| | hisC | Histidinol-phosphate aminotransferase 2; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (371 aa) |
| | ldh | Leucine dehydrogenase; Function of strongly homologous gene; enzyme; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (358 aa) |
| | LHA_1129 | Lycopene cyclase; Function of strongly homologous gene; enzyme. (373 aa) |
| | LHA_1130 | Phytoene synthase; Function of strongly homologous gene; enzyme. (283 aa) |
| | crtI | Phytoene dehydrogenase. (492 aa) |
| | LHA_1132 | Putative (2E,6E)-farnesyl diphosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the FPP/GGPP synthase family. (279 aa) |
| | rpe | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (219 aa) |
| | xanB | Xanthan biosynthesis protein xanB [Includes: Mannose-6-phosphate isomerase; Mannose-1-phosphate guanylyl transferase]; Belongs to the mannose-6-phosphate isomerase type 2 family. (473 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit hisH 1; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa) |
| | hisF | Putative imidazole glycerol phosphate synthase subunit hisF2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the HisA/HisF family. (272 aa) |
| | rmlD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (290 aa) |
| | rmlB | dTDP-glucose 4,6 dehydratase, NAD(P)-binding; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (357 aa) |
| | rmlA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (307 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (490 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | sdaA | L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (510 aa) |
| | ppsA | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (793 aa) |
| | icd | Isocitrate dehydrogenase [NADP]. (418 aa) |
| | LHA_1307 | 3-hydroxyisobutyryl-CoA hydrolase; Function of strongly homologous gene; enzyme. (349 aa) |
| | LHA_1343 | Putative Hypoxanthine phosphoribosyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (278 aa) |
| | iucD | L-lysine 6-monooxygenase (NADPH); Function of strongly homologous gene; enzyme. (437 aa) |
| | ribD | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (356 aa) |
| | ribE | Riboflavin synthase alpha chain. (205 aa) |
| | ribBA | Riboflavin biosynthesis protein ribBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (402 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (161 aa) |
| | hisI | Histidine biosynthesis bifunctional protein hisIE [Includes: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase]; In the N-terminal section; belongs to the PRA-CH family. (202 aa) |
| | hisF-2 | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (255 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (245 aa) |
| | hisH-2 | Imidazole glycerol phosphate synthase subunit hisH 2; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (199 aa) |
| | hisB | Histidine biosynthesis bifunctional protein hisB [Includes: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase]. (352 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase 1. (350 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (433 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (292 aa) |
| | trpE(G | Anthranilate synthase [Includes: Glutamine amidotransferase]. (714 aa) |
| | guaB | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa) |
| | ubiG | 3-demethylubiquinone-9 3-methyltransferase; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the methyltransferase superfamily. UbiG/COQ3 family. (233 aa) |
| | putA | Bifunctional protein putA [Includes: Proline dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1050 aa) |
| | acn | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (490 aa) |
| | pgl | 6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (226 aa) |
| | glk | Glucokinase; Belongs to the bacterial glucokinase family. (335 aa) |
| | LHA_1543 | Thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (439 aa) |
| | yfcX | YfcX enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. (673 aa) |
| | LHA_1557 | Putative phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (254 aa) |
| | LHA_1574 | Branched-chain alpha-keto acid dehydrogenase subunit E2. (371 aa) |
| | pdhB | Pyruvate dehydrogenase E1 component subunit beta. (324 aa) |
| | pdhA | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | LHA_1599 | Homologs of previously reported genes of unknown function. (140 aa) |
| | hemL | Glutamate-1-semialdehyde 2,1-aminomutase. (431 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase. (186 aa) |
| | ilvE | Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (300 aa) |
| | alsS | Acetolactate synthase; Belongs to the TPP enzyme family. (548 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (82 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (248 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (316 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (342 aa) |
| | adhA | Putative alcohol dehydrogenase AdhA; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (334 aa) |
| | fadA | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | alh | Putative aldehyde dehydrogenase family 7 member A1 homolog; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the aldehyde dehydrogenase family. (505 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (293 aa) |
| | xapA | Purine nucleoside phosphorylase II; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (276 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. (280 aa) |
| | ubiC | 4-hydroxybenzoate synthetase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. (177 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (439 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (362 aa) |
| | gltA | Citrate synthase; Belongs to the citrate synthase family. (423 aa) |
| | glpD | Glycerol-3-phosphate dehydrogenase; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (493 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | lpdA | Dihydrolipoyl dehydrogenase. (475 aa) |
| | aceF | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (536 aa) |
| | aceE | Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (888 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (399 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (210 aa) |
| | surE | 5'-nucleotidase surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa) |
| | LHA_1985 | Ribose-phosphate pyrophosphokinase. (328 aa) |
| | algC-2 | Phosphomannomutase/phosphoglucomutase. (470 aa) |
| | hemF | Coproporphyrinogen-III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (310 aa) |
| | LHA_2056 | Putative O-methyltransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (332 aa) |
| | metC | Cystathionine beta-lyase. (384 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (256 aa) |
| | LHA_2122 | Ornithine cyclodeaminase/mu-crystallin family protein. (322 aa) |
| | ubiX | Putative aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (189 aa) |
| | korB | 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (324 aa) |
| | korA | 2-oxoglutarate synthase subunit korA; Function of strongly homologous gene; enzyme. (602 aa) |
| | ribF | Riboflavin biosynthesis protein ribF [Includes: Riboflavin kinase; FMN adenylyltransferase]; Belongs to the ribF family. (313 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (367 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (161 aa) |
| | gtaB | UTP--glucose-1-phosphate uridylyltransferase. (290 aa) |
| | suhB | Inositol-1-monophosphatase. (262 aa) |
| | lysC | Aspartokinase; Belongs to the aspartokinase family. (431 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (328 aa) |
| | LHA_2285 | Bifunctional aspartate kinase/diaminopimelate decarboxylase protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (854 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (330 aa) |
| | cyoE | Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (294 aa) |
| | LHA_2426 | Cytochrome oxidase assembly family protein (fragment). (338 aa) |
| | katG | Catalase-peroxidase 2; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (748 aa) |
| | fumB | Fumarate hydratase, class I, anaerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (508 aa) |
| | fabI-2 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (251 aa) |
| | yjgB | Uncharacterized zinc-type alcohol dehydrogenase-like protein yjgB. (335 aa) |
| | LHA_2608 | Putative MbtH-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (71 aa) |
| | serC-2 | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa) |
| | LHA_2612 | Putative phosphoserine phosphatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (251 aa) |
| | LHA_2613 | Putative D-isomer specific 2-hydroxyacid dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (401 aa) |
| | hmgA-2 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Belongs to the HMG-CoA reductase family. (432 aa) |
| | fni | Isopentenyl-diphosphate delta-isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (342 aa) |
| | LHA_2679 | Diphosphomevalonate decarboxylase; Function of strongly homologous gene; enzyme. (315 aa) |
| | LHA_2680 | Putative mevalonate kinase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology. (294 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (425 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (312 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (315 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (252 aa) |
| | LHA_2772 | Homologs of previously reported genes of unknown function. (374 aa) |
| | wrbA-2 | Flavoprotein wrbA; Belongs to the WrbA family. (201 aa) |
| | yahK | Putative oxidoreductase, Zn-dependent and NAD(P)-binding; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (349 aa) |
| | GCDH | Glutaryl-CoA dehydrogenase, mitochondrial. (385 aa) |
| | LHA_2872 | 2-oxoisovalerate dehydrogenase, E1 component, alpha and beta fusion. (746 aa) |
| | ltaE | Low specificity L-threonine aldolase. (342 aa) |
| | plsC | 1-acylglycerol-3-phosphate O-acyltransferase; Function of strongly homologous gene; enzyme. (245 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | sucD | Succinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (291 aa) |
| | sucC | Succinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (386 aa) |
| | sucB | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (403 aa) |
| | odhA | 2-oxoglutarate dehydrogenase E1 component. (934 aa) |
| | sdhB | Succinate dehydrogenase iron-sulfur subunit. (240 aa) |
| | sdhA | Succinate dehydrogenase flavoprotein subunit; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (589 aa) |
| | sdhD | Succinate dehydrogenase hydrophobic membrane anchor subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH). (115 aa) |
| | sdhC | Succinate dehydrogenase cytochrome b556 subunit. (128 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (262 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (252 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa) |
| | FrgA | Siderophore biosynthetic enzyme FrgA; Function of strongly homologous gene; enzyme. (578 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (229 aa) |
| | LHA_3071 | Isoaspartyl peptidase/L-asparaginase. (303 aa) |
| | LHA_3083 | Putative Pyridoxal 4-dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (357 aa) |
| | argE | Acetylornithine deacetylase. (389 aa) |
| | LHA_3095 | Inosine 5'-monophosphate dehydrogenase. (337 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (228 aa) |
| | cysK | Cysteine synthase; Function of strongly homologous gene; enzyme. (316 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (389 aa) |
| | aroK-2 | Putative shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (176 aa) |
| | ubiD | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (489 aa) |
| | fumC | Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa) |
| | psd | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (285 aa) |
| | LHA_3252 | Acyl CoA dehydrogenase, short chain specific. (569 aa) |
