(6 nodes) Glycine metabolic process, and Cobalamin binding network (Microcystis aeruginosa)

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	metH	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1187 aa)
	gcvH	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
	glyA	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
	gcvP	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (981 aa)
	MAE_39290	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
	gcvT	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)

Your Current Organism:

Microcystis aeruginosa

NCBI taxonomy Id: 449447
Other names: M. aeruginosa NIES-843, Microcystis aeruginosa NIES-843

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAE_39290	gcvP	MAE_39290	MAE_39020	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.535
MAE_39290	gcvT	MAE_39290	MAE_58940	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.936
MAE_39290	glyA	MAE_39290	MAE_38800	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.951
MAE_39290	metH	MAE_39290	MAE_21380	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.997
gcvH	gcvP	MAE_32670	MAE_39020	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.999
gcvH	gcvT	MAE_32670	MAE_58940	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvH	glyA	MAE_32670	MAE_38800	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.968
gcvH	metH	MAE_32670	MAE_21380	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.455
gcvP	MAE_39290	MAE_39020	MAE_39290	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.535
gcvP	gcvH	MAE_39020	MAE_32670	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
gcvP	gcvT	MAE_39020	MAE_58940	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	0.999
gcvP	glyA	MAE_39020	MAE_38800	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.997
gcvP	metH	MAE_39020	MAE_21380	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.660
gcvT	MAE_39290	MAE_58940	MAE_39290	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.936
gcvT	gcvH	MAE_58940	MAE_32670	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
gcvT	gcvP	MAE_58940	MAE_39020	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.999
gcvT	glyA	MAE_58940	MAE_38800	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.996
gcvT	metH	MAE_58940	MAE_21380	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.	5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.957
glyA	MAE_39290	MAE_38800	MAE_39290	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.951
glyA	gcvH	MAE_38800	MAE_32670	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.968