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ntcA ntcA MAE_01980 MAE_01980 argG argG rpiA rpiA MAE_02620 MAE_02620 nirA nirA ackA ackA MAE_03940 MAE_03940 MAE_05230 MAE_05230 ldh ldh acoB acoB pckA pckA fumC fumC gltB gltB MAE_07860 MAE_07860 lipA lipA gdhA gdhA MAE_08800 MAE_08800 MAE_08890 MAE_08890 glnN glnN mdh mdh MAE_10360 MAE_10360 MAE_11030 MAE_11030 MAE_11040 MAE_11040 pgl pgl tpi tpi MAE_13670 MAE_13670 gltD gltD MAE_14970 MAE_14970 MAE_15220 MAE_15220 leuB-2 leuB-2 argD argD pgi pgi MAE_17590 MAE_17590 MAE_17690 MAE_17690 lipB lipB nirA-2 nirA-2 MAE_18450 MAE_18450 glnA glnA argC argC argH argH MAE_21280 MAE_21280 metH metH proB proB prs prs fbp fbp argB argB MAE_25030 MAE_25030 MAE_25340 MAE_25340 glmS glmS glk glk MAE_27980 MAE_27980 MAE_28130 MAE_28130 glsF glsF MAE_29120 MAE_29120 MAE_29860 MAE_29860 MAE_30020 MAE_30020 argD-2 argD-2 proA proA fbaA fbaA gcvH gcvH MAE_32690 MAE_32690 MAE_34870 MAE_34870 MAE_34890 MAE_34890 eno eno MAE_37250 MAE_37250 glsA glsA MAE_38140 MAE_38140 MAE_38160 MAE_38160 MAE_38390 MAE_38390 MAE_38470 MAE_38470 glyA glyA ppc ppc gcvP gcvP MAE_39290 MAE_39290 MAE_40010 MAE_40010 MAE_40020 MAE_40020 MAE_41170 MAE_41170 MAE_41860 MAE_41860 MAE_42530 MAE_42530 tal tal zwf zwf pgk pgk pdhA pdhA MAE_45610 MAE_45610 folD folD MAE_49020 MAE_49020 glmM glmM MAE_49340 MAE_49340 MAE_49470 MAE_49470 proA-2 proA-2 MAE_50450 MAE_50450 putA putA pfkA pfkA purU purU argJ argJ lipA-2 lipA-2 narB narB argF argF MAE_54300 MAE_54300 MAE_55440 MAE_55440 proC proC MAE_55930 MAE_55930 MAE_56250 MAE_56250 glnB glnB hcp hcp gcvT gcvT glnB-2 glnB-2 acsA acsA MAE_59640 MAE_59640 glmU glmU MAE_60410 MAE_60410 MAE_60960 MAE_60960 deoC deoC MAE_61240 MAE_61240 rpe rpe MAE_61820 MAE_61820 icd icd
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ntcAGlobal nitrogen regulator Ycf28. (225 aa)
MAE_01980Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (458 aa)
argGArgininosuccinate synthetase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (401 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (236 aa)
MAE_02620Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (813 aa)
nirAFerredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (321 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
MAE_03940Pyruvate kinase; Belongs to the pyruvate kinase family. (509 aa)
MAE_05230Citrate synthase; Belongs to the citrate synthase family. (379 aa)
ldhL-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (331 aa)
acoBPyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (540 aa)
fumCFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
gltBNADH-dependent glutamate synthase large subunit. (1524 aa)
MAE_07860Malic enzyme. (463 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (291 aa)
gdhAGlutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (431 aa)
MAE_08800Putative 5-oxoprolinase. (679 aa)
MAE_08890Fructokinase. (331 aa)
glnNGlutamate--ammonia ligase; Belongs to the glutamine synthetase family. (723 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (325 aa)
MAE_10360Sodium/solute symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (603 aa)
MAE_11030Transketolase-like protein. (274 aa)
MAE_11040Transketolase-like protein. (303 aa)
pgl6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (240 aa)
tpiTriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (230 aa)
MAE_13670Succinate dehydrogenase iron-sulphur protein subunit; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (327 aa)
gltDNADH-dependent glutamate synthase small subunit. (494 aa)
MAE_14970Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (668 aa)
MAE_152206-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (475 aa)
leuB-23-isopropylmalate dehydrogenase. (362 aa)
argDN-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (427 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (524 aa)
MAE_17590Phosphoenolpyruvate synthase. (718 aa)
MAE_17690Ammonium/methylammonium permease. (506 aa)
lipBLipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (217 aa)
nirA-2Ferredoxin--nitrite reductase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (513 aa)
MAE_18450Glucokinase. (305 aa)
glnAGlutamate--ammonia ligase. (473 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (353 aa)
argHL-argininosuccinate lyase. (466 aa)
MAE_21280Glutathione-dependent formaldehyde dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (369 aa)
metH5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1187 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (379 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (323 aa)
fbpFructose-1,6-bisphosphatase. (348 aa)
argBN-acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa)
MAE_25030NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa)
MAE_25340Succinate-semialdehyde dehydrogenase [NAD(P)+]. (454 aa)
glmSL-glutamine:D-fructose-6-P amidotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (633 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (348 aa)
MAE_27980Pyruvate kinase; Belongs to the pyruvate kinase family. (591 aa)
MAE_28130Hydantoinase B/oxoprolinase. (523 aa)
glsFFerredoxin-dependent glutamate synthase. (1534 aa)
MAE_29120succinyl-CoA synthetase alpha chain. (295 aa)
MAE_29860succinyl-CoA synthetase beta chain. (394 aa)
MAE_30020Fructose-1,6-/sedoheptulose-1,7-bisphosphatase; Catalyzes the hydrolysis of fructose 1,6-bisphosphate (Fru 1,6-P2) and sedoheptulose 1,7-bisphosphate (Sed 1,7-P2) to fructose 6- phosphate and sedoheptulose 7-phosphate, respectively; Belongs to the FBPase class 2 family. (345 aa)
argD-2N-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (462 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa)
fbaAFructose-bisphosphate aldolase class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
gcvHGlycine decarboxylase complex H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
MAE_32690acetyl-CoA synthetase. (902 aa)
MAE_34870Putative phosphoketolase. (806 aa)
MAE_34890Glyceraldehyde 3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (344 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (432 aa)
MAE_37250Hypothetical protein; Belongs to the HpcH/HpaI aldolase family. (260 aa)
glsAPutative glutaminase; Belongs to the glutaminase family. (338 aa)
MAE_38140Pyruvate-flavodoxin oxidoreductase; Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin. (1184 aa)
MAE_38160Phosphofructokinase. (402 aa)
MAE_38390Hypothetical protein. (144 aa)
MAE_38470Putative diguanylate cyclase/phosphodiesterase. (606 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (1018 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (981 aa)
MAE_39290Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (297 aa)
MAE_40010Ammonium/methylammonium permease. (478 aa)
MAE_40020Ammonium transporter. (474 aa)
MAE_41170Biotin/lipoate A/B protein ligase family protein. (253 aa)
MAE_41860Glutamate decarboxylase. (185 aa)
MAE_42530Mercuric reductase. (461 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 1 subfamily. (391 aa)
zwfGlucose 6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (509 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (402 aa)
pdhAPyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (344 aa)
MAE_45610Heterodisulfide reductase subunit B. (301 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (285 aa)
MAE_49020Hypothetical protein; Similar to mannose-1-phosphate guanylyltransferase. (133 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (479 aa)
MAE_49340Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (888 aa)
MAE_49470Uncharacterized zinc-type alcohol dehydrogenase-like protein. (334 aa)
proA-2Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (431 aa)
MAE_50450Dihydrolipoamide dehydrogenase. (485 aa)
putAProline oxidase; Belongs to the aldehyde dehydrogenase family. (989 aa)
pfkAPhosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (360 aa)
purUPhosphoribosylglycinamide formyltransferase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
argJArginine biosynthesis bifunctional protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
lipA-2Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (294 aa)
narBFerredoxin-nitrate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (730 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (308 aa)
MAE_54300HAD-superfamily hydrolase subfamily IA, variant 3. (245 aa)
MAE_55440Pyruvate kinase; Belongs to the pyruvate kinase family. (473 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa)
MAE_55930Hypothetical protein. (90 aa)
MAE_56250Succinate dehydrogenase flavoprotein subunit. (575 aa)
glnBNitrogen regulatory protein P-II; Belongs to the P(II) protein family. (112 aa)
hcpHydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (542 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (368 aa)
glnB-2Nitrogen regulatory protein P-II; gene:glnB or glnK. (105 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (656 aa)
MAE_59640Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component; Component E2. (419 aa)
glmUUDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (452 aa)
MAE_60410Putative glutaminase; Belongs to the glutaminase family. (297 aa)
MAE_60960Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (698 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (225 aa)
MAE_61240Aconitate hydratase; Belongs to the aconitase/IPM isomerase family. (869 aa)
rpePentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (235 aa)
MAE_61820Transketolase. (633 aa)
icdIsocitrate dehydrogenase (NADP+). (478 aa)
Your Current Organism:
Microcystis aeruginosa
NCBI taxonomy Id: 449447
Other names: M. aeruginosa NIES-843, Microcystis aeruginosa NIES-843
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