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MAE_02680 MAE_02680 cobH cobH cobI cobI cbiX cbiX cobB cobB pcyA pcyA hemF hemF hemH hemH chlH chlH por por ho1 ho1 chlL chlL chlN chlN cbiD cbiD cobO cobO chlG chlG hemB hemB ctaB ctaB ctaA ctaA MAE_23210 MAE_23210 cobM cobM cobJ cobJ MAE_28690 MAE_28690 hemA hemA cobS cobS hemE hemE hemH-2 hemH-2 cobD cobD cobP cobP cbiJ cbiJ hemL hemL acsF acsF hemB-2 hemB-2 MAE_40060 MAE_40060 cobJ-2 cobJ-2 hemC hemC cobN cobN chlD chlD acsF-2 acsF-2 MAE_47270 MAE_47270 chlI chlI chlP chlP gltX gltX chlB chlB hemD hemD chlM chlM cobQ cobQ chlH-2 chlH-2 bvdR bvdR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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MAE_02680Precorrin-6y C5,15-methyltransferase (decarboxylating). (410 aa)
cobHprecorrin-8X methylmutase; Precorrin isomerase. (208 aa)
cobIPrecorrin-2 methyltransferase; Belongs to the precorrin methyltransferase family. (234 aa)
cbiXCobalamin biosynthesis protein. (236 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (458 aa)
pcyAPhycocyanobilin:ferredoxin oxidoreductase; Catalyzes the four-electron reduction of biliverdin IX-alpha (2-electron reduction at both the A and D rings); the reaction proceeds via an isolatable 2-electron intermediate, 181,182-dihydrobiliverdin. Belongs to the HY2 family. (245 aa)
hemFCoproporphyrinogen III oxidase, aerobic; Involved in the heme and chlorophyll biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX. (315 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (387 aa)
chlHMagnesium protoporphyrin IX chelatase subunit H. (1328 aa)
porLight-dependent NADPH-protochlorophyllide oxidoreductase; Phototransformation of protochlorophyllide (Pchlide) to chlorophyllide (Chlide). (320 aa)
ho1Heme oxygenase. (239 aa)
chlLLight-independent protochlorophyllide reductase iron protein subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The L component serves as a unique electron donor to the NB-component of the complex, and binds Mg-ATP. (289 aa)
chlNLight-independent protochlorophyllide reductase subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (466 aa)
cbiDCobalamin biosynthesis protein D; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (374 aa)
cobOcob(I)alamin adenosyltransferase. (201 aa)
chlGChlorophyll a synthase. (326 aa)
hemB5-aminolevulinate dehydratase; Porphobilinogen synthase; Belongs to the ALAD family. (325 aa)
ctaBProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (316 aa)
ctaACytochrome c oxidase subunit XV assembly protein. (316 aa)
MAE_23210Hypothetical protein. (195 aa)
cobMPrecorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. (262 aa)
cobJPrecorrin methylase. (170 aa)
MAE_28690Bacterioferritin. (144 aa)
hemATransfer RNA-Gln reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (428 aa)
cobSCobalamin [5'-phosphate] synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (252 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (350 aa)
hemH-2Ferrochelatase; Belongs to the ferrochelatase family. (379 aa)
cobDCobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (326 aa)
cobPBifunctional cobalamin biosynthesis protein. (183 aa)
cbiJPrecorrin-6x reductase; gene:cbiJ or CobK. (251 aa)
hemLGlutamate-1-semialdehyde aminomutase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily. (433 aa)
acsFMagnesium protoporphyrin IX monomethyl ester [oxidative] cyclase 1; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (358 aa)
hemB-2Porphobilinogen synthase; 5-aminolevulinate dehydratase; Belongs to the ALAD family. (328 aa)
MAE_40060Coenzyme F420 hydrogenase subunit beta. (397 aa)
cobJ-2Precorrin methylase. (460 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (319 aa)
cobNCobalt-chelatase subunit. (1213 aa)
chlDMagnesium protoporphyrin IX chelatase subunit D; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (665 aa)
acsF-2Magnesium-protoporphyrin IX monomethylester aerobic cyclization protein homolog; Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME); Belongs to the AcsF family. (352 aa)
MAE_47270uroporphyrin-III C-methyltransferase; Belongs to the precorrin methyltransferase family. (266 aa)
chlIMagnesium protoporphyrin IX chelatase subunit I; Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX. (357 aa)
chlPGeranylgeranyl hydrogenase. (405 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (480 aa)
chlBLight-independent protochlorophyllide reductase subunit; Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (ChlN-ChlB) is the catalytic component of the complex. (508 aa)
hemDuroporphyrinogen-III C-methyltransferase and uroporphyrinogen-III synthase fusion protein; A fusion protein between CobA/CorA and HemD; gene:hemD or cobA. (505 aa)
chlMMagnesium protoporphyrin IX methyl transferase. (230 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (491 aa)
chlH-2Magnesium protoporphyrin IX chelatase subunit H. (1221 aa)
bvdRBiliverdin reductase. (332 aa)
Your Current Organism:
Microcystis aeruginosa
NCBI taxonomy Id: 449447
Other names: M. aeruginosa NIES-843, Microcystis aeruginosa NIES-843
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