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secB secB ffh ffh ftsY ftsY yidC yidC xcsC xcsC xcsD xcsD xcsE xcsE xcsF xcsF xcsG xcsG xcsH xcsH xcsI xcsI xcsJ xcsJ xcsK xcsK xcsL xcsL secA secA secE secE secY secY PHZ_c1342 PHZ_c1342 PHZ_c1509 PHZ_c1509 PHZ_c1752 PHZ_c1752 secF secF secD secD yajC yajC tatC tatC tatB tatB tatA tatA PHZ_c2347 PHZ_c2347 virB2 virB2 virB3 virB3 virB4 virB4 PHZ_c2351 PHZ_c2351 virB6 virB6 virB8 virB8 virB9 virB9 virB10 virB10 PHZ_c2356 PHZ_c2356 virD4 virD4 PHZ_c2917 PHZ_c2917
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (163 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...] (508 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (314 aa)
yidCPreprotein translocase subunit; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (598 aa)
xcsCType II secretion system protein C. (319 aa)
xcsDType II secretory pathway protein D. (686 aa)
xcsEType II secretion system protein E; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (493 aa)
xcsFType II secretion system protein F. (402 aa)
xcsGType II secretion system protein G. (154 aa)
xcsHType II secretion system protein H. (164 aa)
xcsIType II secretion system protein I. (120 aa)
xcsJType II secretion system protein J. (195 aa)
xcsKType II secretion system protein K. (316 aa)
xcsLType II secretion system protein L. (376 aa)
secAPreprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (917 aa)
secEPreprotein translocase, SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. (78 aa)
secYPreprotein translocase SecY subunit; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (450 aa)
PHZ_c1342Type I secretion outer membrane protein, TolC. (512 aa)
PHZ_c1509virD4, type IV secretion protein. (658 aa)
PHZ_c1752Preprotein translocase, SecG subunit; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (149 aa)
secFProtein-export membrane protein SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (320 aa)
secDProtein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (534 aa)
yajCPreprotein translocase, YajC subunit; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (116 aa)
tatCSec-independent protein secretion pathway component TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (299 aa)
tatBSec-independent protein secretion pathway components TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (178 aa)
tatASec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (70 aa)
PHZ_c2347Conjugal transfer protein. (205 aa)
virB2Type IV secretory pathway, VirB2 components (pilins). (99 aa)
virB3Type IV secretory pathway, VirB3 component. (112 aa)
virB4Type IV secretory pathway, VirB4 component. (793 aa)
PHZ_c2351Conserved hypothetical protein. (242 aa)
virB6Type IV secretory pathway, VirB6 component. (312 aa)
virB8Type IV secretory pathway, component VirB8. (226 aa)
virB9Type IV secretory pathway, VirB9 component. (282 aa)
virB10Type IV secretory pathway, VirB10 component. (346 aa)
PHZ_c2356virB11 type IV secretion protein. (330 aa)
virD4Type IV secretory pathway, VirD4 component. (594 aa)
PHZ_c2917Hypothetical protein; Belongs to the bacterial secretin family. (612 aa)
Your Current Organism:
Phenylobacterium zucineum
NCBI taxonomy Id: 450851
Other names: P. zucineum HLK1, Phenylobacterium zucineum HLK1, Phenylobacterium zucineum str. HLK1, Phenylobacterium zucineum strain HLK1
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