STRINGSTRING
ARG97183.1 ARG97183.1 ARG98778.1 ARG98778.1 gmhA gmhA atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC GER GER gmd gmd rfbG-2 rfbG-2 ARG98734.1 ARG98734.1 ARG98733.1 ARG98733.1 ARG98731.1 ARG98731.1 ARG98728.1 ARG98728.1 ARG98950.1 ARG98950.1 dcd dcd lpxD-2 lpxD-2 ARG98625.1 ARG98625.1 ARG98562.1 ARG98562.1 ARG98543.1 ARG98543.1 waaM waaM ARG98462.1 ARG98462.1 carA-2 carA-2 ARG98398.1 ARG98398.1 ARG98927.1 ARG98927.1 purN purN purD purD purF purF purC purC purQ purQ purM purM purL purL coaBC coaBC dut dut ARG98925.1 ARG98925.1 queF queF nudE nudE purH purH accC-2 accC-2 purA purA uppS uppS lpxD lpxD fabZ fabZ lpxA lpxA ARG98172.1 ARG98172.1 pyrD pyrD lpxK lpxK mviN mviN kdsB kdsB ARG97988.1 ARG97988.1 ARG97986.1 ARG97986.1 nrdB nrdB fliI-2 fliI-2 mpl mpl coaX coaX ftsI ftsI murE murE ARG97907.1 ARG97907.1 ARG97905.1 ARG97905.1 ARG97904.1 ARG97904.1 ARG97903.1 ARG97903.1 udg udg mrcA mrcA ribF ribF kdsC kdsC murA murA ARG97825.1 ARG97825.1 capI capI pyrE pyrE ARG97754.1 ARG97754.1 ARG97706.1 ARG97706.1 ARG97698.1 ARG97698.1 ARG98884.1 ARG98884.1 ARG97658.1 ARG97658.1 pdhA pdhA lpxH lpxH ndk ndk ackA ackA pta pta ARG97602.1 ARG97602.1 ARG97596.1 ARG97596.1 accD accD pbpC pbpC coaE coaE ARG97519.1 ARG97519.1 tmk tmk mltG mltG acpP acpP ARG97476.1 ARG97476.1 mrdB mrdB lpxB lpxB ybeX ybeX pyrF pyrF adk adk aceF aceF ARG97354.1 ARG97354.1 pyrH pyrH guaA guaA guaB guaB ARG97314.1 ARG97314.1 kdsA kdsA pyrG pyrG ARG97277.1 ARG97277.1 ARG97265.1 ARG97265.1 ARG97199.1 ARG97199.1 ARG97198.1 ARG97198.1 murG murG wsfH wsfH purB purB accA accA wbpL wbpL galE galE ARG97158.1 ARG97158.1 ARG97157.1 ARG97157.1 ARG97156.1 ARG97156.1 ARG97149.1 ARG97149.1 ARG97148.1 ARG97148.1 rmlD rmlD ARG97146.1 ARG97146.1 xanB xanB purK purK purE purE ARG97022.1 ARG97022.1 ARG96991.1 ARG96991.1 queA queA fliI fliI ARG96883.1 ARG96883.1 ARG96873.1 ARG96873.1 enhA enhA waaA waaA pyrB pyrB ARG96795.1 ARG96795.1 gpsA gpsA ARG96750.1 ARG96750.1 udk udk murI murI spoT spoT ARG96712.1 ARG96712.1 carA carA upp upp queE queE ARG96600.1 ARG96600.1 ARG96592.1 ARG96592.1 ARG96566.1 ARG96566.1 tgt tgt queH queH ARG98811.1 ARG98811.1 deoB deoB ARG96504.1 ARG96504.1 ARG96496.1 ARG96496.1 lpxC lpxC ddl ddl murB murB murC murC ftsW ftsW murD murD murF murF coaD coaD prs prs ARG96345.1 ARG96345.1 glmS glmS ARG98797.1 ARG98797.1 acsA acsA thyA thyA glmU glmU ARG96297.1 ARG96297.1 queC queC ARG98791.1 ARG98791.1 ARG96278.1 ARG96278.1 yhhQ yhhQ ARG96224.1 ARG96224.1 ARG96219.1 ARG96219.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ARG97183.1Dolichyl-phosphate-mannose--protein mannosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
ARG98778.1Penicillin-binding protein activator; Derived by automated computational analysis using gene prediction method: Protein Homology. (599 aa)
gmhAPhosphoheptose isomerase; Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)
atpBF0F1 ATP synthase subunit A; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (274 aa)
atpEF0F1 ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (91 aa)
atpFF0F1 ATP synthase subunit B; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (156 aa)
atpHF0F1 ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (181 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (517 aa)
atpGF0F1 ATP synthase subunit gamma; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (288 aa)
atpDATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (459 aa)
atpCF0F1 ATP synthase subunit epsilon; Produces ATP from ADP in the presence of a proton gradient across the membrane. (140 aa)
GERGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (326 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (360 aa)
rfbG-2CDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
ARG98734.1Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
ARG98733.1Glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
ARG98731.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
ARG98728.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (933 aa)
ARG98950.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
lpxD-2UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (350 aa)
ARG98625.1Integral membrane family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
ARG98562.1dTDP-6-deoxy-3,4-keto-hexulose isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
ARG98543.1Phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (327 aa)
waaMLipid A biosynthesis acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
ARG98462.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
carA-2Carbamoyl phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
ARG98398.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
ARG98927.1Lipopolysaccharide cholinephosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa)
purDPhosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family. (438 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (502 aa)
purCPhosphoribosylaminoimidazolesuccinocarboxamide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SAICAR synthetase family. (331 aa)
purQPhosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (421 aa)
purMPhosphoribosylformylglycinamidine cyclo-ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
purLPhosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (779 aa)
coaBCBifunctional 4'-phosphopantothenoylcysteine decarboxylase/phosphopantothenoylcysteine synthetase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (406 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa)
ARG98925.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
queFNADPH-dependent 7-cyano-7-deazaguanine reductase QueF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). (415 aa)
nudEADP compounds hydrolase NudE; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
accC-2acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
purAAdenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
uppSDi-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (247 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (347 aa)
fabZbeta-hydroxyacyl-ACP dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (152 aa)
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa)
ARG98172.1Capsular biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (331 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (323 aa)
mviNLeucyl aminopeptidase; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (523 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (250 aa)
ARG97988.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
ARG97986.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
nrdBRibonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (369 aa)
fliI-2Flagellar protein export ATPase FliI; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
coaXType III pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (255 aa)
ftsICell division protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (557 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (486 aa)
ARG97907.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
ARG97905.1Dolichol-phosphate mannosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
ARG97904.1Lipid A biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (106 aa)
ARG97903.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
udgNucleotide sugar dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
mrcAPeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (803 aa)
ribFBifunctional riboflavin kinase/FMN adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (318 aa)
kdsC3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (175 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa)
ARG97825.1Glycosyl hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (353 aa)
capINAD-dependent epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (334 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (210 aa)
ARG97754.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
ARG97706.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (696 aa)
ARG97698.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
ARG98884.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
ARG97658.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (357 aa)
lpxHUDP-2,3-diacylglucosamine diphosphatase; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (246 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
ackAHypothetical protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (390 aa)
ptaPhosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (687 aa)
ARG97602.1Hypoxanthine-guanine phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (186 aa)
ARG97596.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
accDacetyl-CoA carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (290 aa)
pbpCPenicillin-binding protein 1C; Derived by automated computational analysis using gene prediction method: Protein Homology. (767 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa)
ARG97519.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (656 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (216 aa)
mltGABC transporter substrate-binding protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (329 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (82 aa)
ARG97476.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (375 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (392 aa)
ybeXMagnesium/cobalt efflux protein; Involved in the transport of magnesium and cobalt ions; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (230 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (227 aa)
aceFDihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (532 aa)
ARG97354.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (247 aa)
guaAGMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. (525 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (490 aa)
ARG97314.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
kdsA3-deoxy-8-phosphooctulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (273 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa)
ARG97277.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
ARG97265.1Phosphoribosylpyrophosphate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribose-phosphate pyrophosphokinase family. (296 aa)
ARG97199.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
ARG97198.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (363 aa)
wsfHGlycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
purBAdenylosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (456 aa)
accAacetyl-CoA carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
wbpLGlycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
galEHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
ARG97158.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
ARG97157.1Glycosyl transferase family 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
ARG97156.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
ARG97149.1O-antigen translocase; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
ARG97148.1dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (325 aa)
rmlDNAD(P)-dependent oxidoreductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (299 aa)
ARG97146.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
xanBMannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 2 family. (474 aa)
purK5-(carboxyamino)imidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (365 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
ARG97022.1enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
ARG96991.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (337 aa)
fliIFlagellum-specific ATP synthase FliI; Involved in type III protein export during flagellum assembly; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
ARG96883.1L,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
ARG96873.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (203 aa)
enhAL,D-transpeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
waaA3-deoxy-D-manno-octulosonic acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (418 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (296 aa)
ARG96795.1DUF179 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (185 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (329 aa)
ARG96750.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (273 aa)
spoTBifunctional GTP diphosphokinase/guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (707 aa)
ARG96712.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (669 aa)
carACarbamoyl-phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (214 aa)
queE7-carboxy-7-deazaguanine synthase QueE; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (217 aa)
ARG96600.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (710 aa)
ARG96592.1UDP-N-acetylmuramyl peptide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
ARG96566.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
tgtHypothetical protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] (383 aa)
queHHypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (223 aa)
ARG98811.1UDP-N-acetylmuramyl peptide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (411 aa)
ARG96504.1Acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (658 aa)
ARG96496.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (745 aa)
lpxCCell division protein FtsZ; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (304 aa)
ddlD-alanine--D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (363 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (303 aa)
murCUDP-N-acetylmuramate--L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (473 aa)
ftsWCell division protein FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (391 aa)
murDphospho-N-acetylmuramoyl-pentapeptide- transferase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (444 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (444 aa)
coaDPantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (169 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
ARG96345.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (365 aa)
glmSGlutamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (604 aa)
ARG98797.16-pyruvoyl tetrahydrobiopterin synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (630 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (458 aa)
ARG96297.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
queC7-cyano-7-deazaguanine synthase; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (223 aa)
ARG98791.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
ARG96278.1Undecaprenyl-diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
yhhQHypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (205 aa)
ARG96224.1Phospholipid:lipid A palmitoyltransferase; Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors. (187 aa)
ARG96219.1Glycosyl hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (382 aa)
Your Current Organism:
Tatlockia micdadei
NCBI taxonomy Id: 451
Other names: ATCC 33218, CCUG 11882, CIP 103882, DSM 16640, Legionella micdadei, Legionella pittsburghensis, NCTC 11371, T. micdadei, strain TATLOCK
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