STRINGSTRING
Aasi_1744 Aasi_1744 Aasi_1065 Aasi_1065 Aasi_1182 Aasi_1182 Aasi_1205 Aasi_1205 Aasi_1209 Aasi_1209 Aasi_1236 Aasi_1236 Aasi_1340 Aasi_1340 Aasi_1354 Aasi_1354 thyA thyA Aasi_1420 Aasi_1420 Aasi_1430 Aasi_1430 accD accD tpiA tpiA Aasi_1558 Aasi_1558 pdhA pdhA Aasi_1640 Aasi_1640 Aasi_0029 Aasi_0029 atpB atpB atpE atpE atpF atpF atpH atpH atpA atpA atpG atpG dut dut Aasi_0091 Aasi_0091 Aasi_0130 Aasi_0130 eno eno Aasi_0201 Aasi_0201 Aasi_0210 Aasi_0210 Aasi_0227 Aasi_0227 Aasi_0236 Aasi_0236 adk adk Aasi_1686 Aasi_1686 Aasi_0283 Aasi_0283 gpsA gpsA gpmI gpmI Aasi_0288 Aasi_0288 lpxC lpxC lpxD lpxD Aasi_0301 Aasi_0301 accA accA thiL thiL lpxK lpxK Aasi_0458 Aasi_0458 Aasi_0464 Aasi_0464 Aasi_0474 Aasi_0474 Aasi_0535 Aasi_0535 Aasi_0568 Aasi_0568 Aasi_0606 Aasi_0606 Aasi_0635 Aasi_0635 Aasi_0642 Aasi_0642 Aasi_0651 Aasi_0651 dacA dacA Aasi_0698 Aasi_0698 pgk pgk Aasi_0753 Aasi_0753 psd psd atpD atpD folD folD Aasi_1028 Aasi_1028 Aasi_1040 Aasi_1040 Aasi_1051 Aasi_1051
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Aasi_1744Na-solute symporter, HD domain. (641 aa)
Aasi_1065Hypothetical protein; PFAM: PF02657, Fe-S metabolism associated SufE. (328 aa)
Aasi_1182PROSITE: PS00287, Proteinase inhibitor I25, cystatin; PROFILE: PS50994, Integrase, catalytic core; PFAM: PF00665, Integrase, catalytic core; SUPERFAMILY: SSF53098, Polynucleotidyl transferase, Ribonuclease H fold. (424 aa)
Aasi_1205Hypothetical protein. (182 aa)
Aasi_1209Hypothetical protein; Belongs to the pyruvate kinase family. (481 aa)
Aasi_1236Hypothetical protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (219 aa)
Aasi_1340Hypothetical protein; PRINTS: PR01415, Ankyrin; PROFILE: PS50297, Ankyrin;PS50088, Ankyrin; SUPERFAMILY: SSF48403, Ankyrin; PFAM: PF00023, Ankyrin; GENE3D: G3DSA:1.25.40.20, Ankyrin; SMART: SM00248, Ankyrin. (160 aa)
Aasi_1354Hypothetical protein. (278 aa)
thyAHypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
Aasi_1420PRINTS: PR01021, Outer membrane protein, bacterial; PROFILE: PS50293, Tetratricopeptide region;PS50005, Tetratricopeptide region;PS51123, Outer membrane protein, OmpA/MotB, C-terminal; PFAM: PF00691, Outer membrane protein, OmpA/MotB, C-terminal;PF07719, Tetratricopeptide TPR2;PF07676, WD40-like Beta Propeller; SUPERFAMILY: SSF103088, Outer membrane protein, OmpA/MotB, C-terminal; PRODOM: PD000930, Outer membrane protein, OmpA/MotB, C-terminal; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical;G3DSA:2.120.10.30, Six-bladed beta-propeller, TolB-like;G3DSA:3.30.1330.60, Outer memb [...] (461 aa)
Aasi_1430PFAM: PF03811, Insertion element protein; SUPERFAMILY: SSF46689, Homeodomain-like. (352 aa)
accDHypothetical protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (281 aa)
tpiAHypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (267 aa)
Aasi_1558Hypothetical protein. (303 aa)
pdhAHypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (345 aa)
Aasi_1640Hypothetical protein. (291 aa)
Aasi_0029Catalytic domain of components of various dehydrogenase complexes; PFAM: PF07676, WD40-like Beta Propeller; GENE3D: G3DSA:2.120.10.30, Six-bladed beta-propeller, TolB-like. (414 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (339 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpFATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (164 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (202 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (532 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
Aasi_0091CDP-diacylglycerol/serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (233 aa)
Aasi_0130Phospholipase D/Transphosphatidylase; PRINTS: PR00971, Ribosomal protein S10; PANTHER: PTHR11700:SF2, Ribosomal protein S10, bacterial;PTHR11700, Ribosomal protein S10; PFAM: PF00338, Ribosomal protein S10; SUPERFAMILY: SSF54999, Ribosomal protein S10; PRODOM: PD001272, Ribosomal protein S10; GENE3D: G3DSA:3.30.70.600, Ribosomal protein S10; TIGRFAMS: TIGR01049, Ribosomal protein S10, bacterial. (198 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
Aasi_0201Hypothetical protein; PANTHER: PTHR10746:SF2, Ribosomal protein L4;PTHR10746, Ribosomal protein L4/L1e, bacterial-type; PFAM: PF00573, Ribosomal protein L4/L1e; SUPERFAMILY: SSF52166, Ribosomal protein L4/L1e. (412 aa)
Aasi_0210PROFILE: PS50928, Binding-protein-dependent transport systems inner membrane component; PFAM: PF00528, Binding-protein-dependent transport systems inner membrane component. (412 aa)
Aasi_0227Hypothetical protein. (203 aa)
Aasi_0236Hypothetical protein; PRINTS: PR01703, Manganese and iron superoxide dismutase; PANTHER: PTHR11404, Manganese and iron superoxide dismutase; SUPERFAMILY: SSF54719, Manganese and iron superoxide dismutase;SSF46609, Manganese and iron superoxide dismutase; PFAM: PF00081, Manganese and iron superoxide dismutase;PF02777, Manganese and iron superoxide dismutase; PIR: PIRSF000349, Manganese and iron superoxide dismutase; PRODOM: PD000475, Manganese and iron superoxide dismutase. (182 aa)
adkHypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa)
Aasi_1686Hypothetical protein. (183 aa)
Aasi_0283Hypothetical protein; PROFILE: PS51192, Helicase, superfamily 1 and 2, ATP-binding;PS51194, DNA/RNA helicase, C-terminal; PFAM: PF02559, Transcription factor CarD;PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal;PF03461, TRCF;PF00271, DNA/RNA helicase, C-terminal; SMART: SM00487, DEAD-like helicase, N-terminal;SM00490, DNA/RNA helicase, C-terminal; TIGRFAMS: TIGR00580, Transcription-repair coupling factor. (551 aa)
gpsAHypothetical protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (354 aa)
gpmIHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
Aasi_0288Hypothetical protein; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa)
lpxCHypothetical protein; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (464 aa)
lpxDHypothetical protein; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (338 aa)
Aasi_0301Hypothetical protein; PFAM: PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ;PF03331, UDP-3-O-acyl N-acetylglucosamine deacetylase; PRODOM: PD011499, UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal; GENE3D: G3DSA:3.30.230.20, UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal;G3DSA:3.30.1700.10, UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal; TIGRFAMS: TIGR01750, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ;TIGR00325, UDP-3-O-acyl N-acetylglucosamine deacetylase; Belongs to the CinA family. (416 aa)
accAHypothetical protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
thiLHypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (339 aa)
lpxKHypothetical protein; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (364 aa)
Aasi_0458Hypothetical protein; PFAM: PF02606, Tetraacyldisaccharide-1-P 4'-kinase; TIGRFAMS: TIGR00682, Tetraacyldisaccharide-1-P 4'-kinase. (214 aa)
Aasi_0464Hypothetical protein; PRINTS: PR00019, Leucine-rich repeat; SUPERFAMILY: SSF50129, GroES-like;SSF52151, Acyl transferase/acyl hydrolase/lysophospholipase; PFAM: PF08238, Sel1-like;PF00560, Leucine-rich repeat;PF01734, Patatin; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical; SMART: SM00671, Sel1-like. (214 aa)
Aasi_0474Hypothetical protein; PFAM: PF03400, Transposase, IS1; Belongs to the NDK family. (130 aa)
Aasi_0535Hypothetical protein. (355 aa)
Aasi_0568Hypothetical protein; PROFILE: PS51192, Helicase, superfamily 1 and 2, ATP-binding;PS51194, DNA/RNA helicase, C-terminal; PFAM: PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal;PF00271, DNA/RNA helicase, C-terminal; SMART: SM00487, DEAD-like helicase, N-terminal;SM00490, DNA/RNA helicase, C-terminal; TIGRFAMS: TIGR00595, Primosomal protein n. (187 aa)
Aasi_0606PRINTS: PR00062, Ribosomal protein L20, bacterial-type; PROSITE: PS00937, Ribosomal protein L20, bacterial-type; PANTHER: PTHR10986, Ribosomal protein L20; PFAM: PF00453, Ribosomal protein L20; PRODOM: PD002389, Ribosomal protein L20; TIGRFAMS: TIGR01032, Ribosomal protein L20, bacterial-type. (196 aa)
Aasi_0635Hypothetical protein. (409 aa)
Aasi_0642Hypothetical protein; PRINTS: PR01038, Arginyl-tRNA synthetase, class Ic, core; PROSITE: PS00178, Aminoacyl-tRNA synthetase, class I, conserved site; PANTHER: PTHR11956, Arginyl-tRNA synthetase, class Ic; SUPERFAMILY: SSF47323, Aminoacyl-tRNA synthetase, class 1a, anticodon-binding;SSF55190, Arginyl tRNA synthetase, class Ic, N-terminal; PFAM: PF05746, DALR anticodon binding;PF00750, Arginyl-tRNA synthetase, class Ic, core;PF03485, Arginyl tRNA synthetase, class Ic, N-terminal; GENE3D: G3DSA:3.40.50.620, Rossmann-like alpha/beta/alpha sandwich fold; TIGRFAMS: TIGR00456, Arginyl-tRNA sy [...] (450 aa)
Aasi_0651Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (264 aa)
Aasi_0698Hypothetical protein; PANTHER: PTHR11088, tRNA isopentenyltransferase; PFAM: PF01715, tRNA isopentenyltransferase; PRODOM: PD005388, Isopentenyl transferase-like;PD004674, tRNA isopentenyltransferase; TIGRFAMS: TIGR00174, tRNA isopentenyltransferase. (197 aa)
pgkHypothetical protein; Belongs to the phosphoglycerate kinase family. (401 aa)
Aasi_0753Hypothetical protein; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (370 aa)
psdHypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (225 aa)
atpDHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa)
folDHypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
Aasi_1028Hypothetical protein; PROSITE: PS00120, Lipase, active site; PROFILE: PS50293, Tetratricopeptide region;PS50005, Tetratricopeptide region; PFAM: PF07719, Tetratricopeptide TPR2;PF00515, Tetratricopeptide TPR-1; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical; SMART: SM00671, Sel1-like;SM00028, Tetratricopeptide region. (82 aa)
Aasi_1040Hypothetical protein. (643 aa)
Aasi_1051Hypothetical protein; PFAM: PF03400, Transposase, IS1. (191 aa)
Your Current Organism:
Amoebophilus asiaticus
NCBI taxonomy Id: 452471
Other names: C. Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus str. 5a2, Candidatus Amoebophilus asiaticus strain 5a2
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