STRINGSTRING
dut dut atpG atpG atpA atpA atpH atpH atpF atpF pdhA pdhA Aasi_1597 Aasi_1597 Aasi_1558 Aasi_1558 Aasi_1447 Aasi_1447 accD accD thyA thyA nusG nusG rpoB rpoB rpoC rpoC Aasi_1195 Aasi_1195 Aasi_1063 Aasi_1063 Aasi_1062 Aasi_1062 Aasi_0014 Aasi_0014 tgt tgt Aasi_0029 Aasi_0029 murA murA atpB atpB atpE atpE Aasi_1028 Aasi_1028 Aasi_0948 Aasi_0948 folD folD atpD atpD dnaG dnaG Aasi_0789 Aasi_0789 queA queA dacA dacA Aasi_0651 Aasi_0651 Aasi_0650 Aasi_0650 Aasi_0635 Aasi_0635 Aasi_0634 Aasi_0634 Aasi_0608 Aasi_0608 Aasi_0536 Aasi_0536 Aasi_0535 Aasi_0535 priA priA Aasi_0474 Aasi_0474 Aasi_0464 Aasi_0464 Aasi_0458 Aasi_0458 Aasi_0422 Aasi_0422 dnaX dnaX polA polA accA accA Aasi_0301 Aasi_0301 adk adk rho rho Aasi_0239 Aasi_0239 Aasi_0238 Aasi_0238 rpoA rpoA Aasi_0152 Aasi_0152 nusA nusA Aasi_0137 Aasi_0137
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (532 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (202 aa)
atpFATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (164 aa)
pdhAHypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (345 aa)
Aasi_1597Hypothetical protein. (566 aa)
Aasi_1558Hypothetical protein. (303 aa)
Aasi_1447Hypothetical protein; PANTHER: PTHR11138, Methionine tRNA Formyltransferase-like; PFAM: PF00551, Formyl transferase, N-terminal;PF02911, Formyl transferase, C-terminal; SUPERFAMILY: SSF53328, Formyl transferase, N-terminal;SSF50486, Formyl transferase, C-terminal-like; GENE3D: G3DSA:3.40.50.170, Formyl transferase, N-terminal;G3DSA:3.10.25.10, Formyl transferase, C-terminal; TIGRFAMS: TIGR00460, Methionyl-tRNA formyltransferase. (341 aa)
accDHypothetical protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (281 aa)
thyAHypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
nusGHypothetical protein; Participates in transcription elongation, termination and antitermination. (186 aa)
rpoBHypothetical protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1286 aa)
rpoCHypothetical protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1433 aa)
Aasi_1195Hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (109 aa)
Aasi_1063Hypothetical protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (290 aa)
Aasi_1062Hypothetical protein; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (186 aa)
Aasi_0014RNA polymerase sigma factor, sigma-70 family; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (287 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (374 aa)
Aasi_0029Catalytic domain of components of various dehydrogenase complexes; PFAM: PF07676, WD40-like Beta Propeller; GENE3D: G3DSA:2.120.10.30, Six-bladed beta-propeller, TolB-like. (414 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (442 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (339 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
Aasi_1028Hypothetical protein; PROSITE: PS00120, Lipase, active site; PROFILE: PS50293, Tetratricopeptide region;PS50005, Tetratricopeptide region; PFAM: PF07719, Tetratricopeptide TPR2;PF00515, Tetratricopeptide TPR-1; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical; SMART: SM00671, Sel1-like;SM00028, Tetratricopeptide region. (82 aa)
Aasi_0948Hypothetical protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (509 aa)
folDHypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
atpDHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa)
dnaGHypothetical protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (640 aa)
Aasi_0789Hypothetical protein; PRINTS: PR00477, Phosphoglycerate kinase; PANTHER: PTHR11406, Phosphoglycerate kinase; SUPERFAMILY: SSF53748, Phosphoglycerate kinase; PFAM: PF00162, Phosphoglycerate kinase; GENE3D: G3DSA:3.40.50.1270, Phosphoglycerate kinase, C-terminal;G3DSA:3.40.50.1260, Phosphoglycerate kinase, N-terminal. (479 aa)
queAHypothetical protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (348 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (264 aa)
Aasi_0651Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
Aasi_0650Hypothetical protein. (1148 aa)
Aasi_0635Hypothetical protein. (409 aa)
Aasi_0634Hypothetical protein. (381 aa)
Aasi_0608PFAM: PF02562, PhoH-like protein. (1404 aa)
Aasi_0536Hypothetical protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
Aasi_0535Hypothetical protein. (355 aa)
priAHypothetical protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (832 aa)
Aasi_0474Hypothetical protein; PFAM: PF03400, Transposase, IS1; Belongs to the NDK family. (130 aa)
Aasi_0464Hypothetical protein; PRINTS: PR00019, Leucine-rich repeat; SUPERFAMILY: SSF50129, GroES-like;SSF52151, Acyl transferase/acyl hydrolase/lysophospholipase; PFAM: PF08238, Sel1-like;PF00560, Leucine-rich repeat;PF01734, Patatin; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical; SMART: SM00671, Sel1-like. (214 aa)
Aasi_0458Hypothetical protein; PFAM: PF02606, Tetraacyldisaccharide-1-P 4'-kinase; TIGRFAMS: TIGR00682, Tetraacyldisaccharide-1-P 4'-kinase. (214 aa)
Aasi_0422Hypothetical protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (378 aa)
dnaXHypothetical protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (629 aa)
polAHypothetical protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (936 aa)
accAHypothetical protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
Aasi_0301Hypothetical protein; PFAM: PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ;PF03331, UDP-3-O-acyl N-acetylglucosamine deacetylase; PRODOM: PD011499, UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal; GENE3D: G3DSA:3.30.230.20, UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal;G3DSA:3.30.1700.10, UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal; TIGRFAMS: TIGR01750, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ;TIGR00325, UDP-3-O-acyl N-acetylglucosamine deacetylase; Belongs to the CinA family. (416 aa)
adkHypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa)
rhoHypothetical protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (512 aa)
Aasi_0239Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (233 aa)
Aasi_0238Hypothetical protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (230 aa)
rpoADNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa)
Aasi_0152DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa)
nusATranscription termination factor NusA; Participates in both transcription termination and antitermination. (411 aa)
Aasi_0137Conserved hypothetical protein; PRINTS: PR01415, Ankyrin; PROFILE: PS50297, Ankyrin;PS50088, Ankyrin; PFAM: PF00023, Ankyrin; SUPERFAMILY: SSF48403, Ankyrin; GENE3D: G3DSA:1.25.40.20, Ankyrin; SMART: SM00248, Ankyrin. (241 aa)
Your Current Organism:
Amoebophilus asiaticus
NCBI taxonomy Id: 452471
Other names: C. Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus str. 5a2, Candidatus Amoebophilus asiaticus strain 5a2
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.