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Aasi_1686 Aasi_1686 Aasi_0091 Aasi_0091 dut dut atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB Aasi_0029 Aasi_0029 Aasi_1028 Aasi_1028 Aasi_1051 Aasi_1051 Aasi_1205 Aasi_1205 Aasi_1236 Aasi_1236 thyA thyA accD accD Aasi_1558 Aasi_1558 pdhA pdhA Aasi_1640 Aasi_1640 Aasi_0753 Aasi_0753 psd psd atpD atpD folD folD dacA dacA Aasi_0651 Aasi_0651 Aasi_0635 Aasi_0635 Aasi_0568 Aasi_0568 Aasi_0535 Aasi_0535 Aasi_0474 Aasi_0474 Aasi_0464 Aasi_0464 Aasi_0458 Aasi_0458 lpxK lpxK thiL thiL accA accA Aasi_0301 Aasi_0301 lpxD lpxD lpxC lpxC Aasi_0288 Aasi_0288 gpsA gpsA Aasi_0283 Aasi_0283 adk adk Aasi_0227 Aasi_0227 Aasi_0210 Aasi_0210 Aasi_0201 Aasi_0201 Aasi_0130 Aasi_0130
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Aasi_1686Hypothetical protein. (183 aa)
Aasi_0091CDP-diacylglycerol/serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (233 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (144 aa)
atpGATP synthase F1, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa)
atpAATP synthase F1, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (532 aa)
atpHATP synthase F1, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (202 aa)
atpFATP synthase F0, B subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (164 aa)
atpEATP synthase F0, C subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpBATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (339 aa)
Aasi_0029Catalytic domain of components of various dehydrogenase complexes; PFAM: PF07676, WD40-like Beta Propeller; GENE3D: G3DSA:2.120.10.30, Six-bladed beta-propeller, TolB-like. (414 aa)
Aasi_1028Hypothetical protein; PROSITE: PS00120, Lipase, active site; PROFILE: PS50293, Tetratricopeptide region;PS50005, Tetratricopeptide region; PFAM: PF07719, Tetratricopeptide TPR2;PF00515, Tetratricopeptide TPR-1; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical; SMART: SM00671, Sel1-like;SM00028, Tetratricopeptide region. (82 aa)
Aasi_1051Hypothetical protein; PFAM: PF03400, Transposase, IS1. (191 aa)
Aasi_1205Hypothetical protein. (182 aa)
Aasi_1236Hypothetical protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (219 aa)
thyAHypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
accDHypothetical protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (281 aa)
Aasi_1558Hypothetical protein. (303 aa)
pdhAHypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (345 aa)
Aasi_1640Hypothetical protein. (291 aa)
Aasi_0753Hypothetical protein; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (370 aa)
psdHypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (225 aa)
atpDHypothetical protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (502 aa)
folDHypothetical protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (298 aa)
dacAHypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (264 aa)
Aasi_0651Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (325 aa)
Aasi_0635Hypothetical protein. (409 aa)
Aasi_0568Hypothetical protein; PROFILE: PS51192, Helicase, superfamily 1 and 2, ATP-binding;PS51194, DNA/RNA helicase, C-terminal; PFAM: PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal;PF00271, DNA/RNA helicase, C-terminal; SMART: SM00487, DEAD-like helicase, N-terminal;SM00490, DNA/RNA helicase, C-terminal; TIGRFAMS: TIGR00595, Primosomal protein n. (187 aa)
Aasi_0535Hypothetical protein. (355 aa)
Aasi_0474Hypothetical protein; PFAM: PF03400, Transposase, IS1; Belongs to the NDK family. (130 aa)
Aasi_0464Hypothetical protein; PRINTS: PR00019, Leucine-rich repeat; SUPERFAMILY: SSF50129, GroES-like;SSF52151, Acyl transferase/acyl hydrolase/lysophospholipase; PFAM: PF08238, Sel1-like;PF00560, Leucine-rich repeat;PF01734, Patatin; GENE3D: G3DSA:1.25.40.10, Tetratricopeptide-like helical; SMART: SM00671, Sel1-like. (214 aa)
Aasi_0458Hypothetical protein; PFAM: PF02606, Tetraacyldisaccharide-1-P 4'-kinase; TIGRFAMS: TIGR00682, Tetraacyldisaccharide-1-P 4'-kinase. (214 aa)
lpxKHypothetical protein; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (364 aa)
thiLHypothetical protein; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (339 aa)
accAHypothetical protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
Aasi_0301Hypothetical protein; PFAM: PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ;PF03331, UDP-3-O-acyl N-acetylglucosamine deacetylase; PRODOM: PD011499, UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal; GENE3D: G3DSA:3.30.230.20, UDP-3-O-acyl N-acetylglucosamine deacetylase, N-terminal;G3DSA:3.30.1700.10, UDP-3-O-acyl N-acetylglucosamine deacetylase, C-terminal; TIGRFAMS: TIGR01750, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase FabZ;TIGR00325, UDP-3-O-acyl N-acetylglucosamine deacetylase; Belongs to the CinA family. (416 aa)
lpxDHypothetical protein; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (338 aa)
lpxCHypothetical protein; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the thioester dehydratase family. FabZ subfamily. (464 aa)
Aasi_0288Hypothetical protein; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa)
gpsAHypothetical protein; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (354 aa)
Aasi_0283Hypothetical protein; PROFILE: PS51192, Helicase, superfamily 1 and 2, ATP-binding;PS51194, DNA/RNA helicase, C-terminal; PFAM: PF02559, Transcription factor CarD;PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal;PF03461, TRCF;PF00271, DNA/RNA helicase, C-terminal; SMART: SM00487, DEAD-like helicase, N-terminal;SM00490, DNA/RNA helicase, C-terminal; TIGRFAMS: TIGR00580, Transcription-repair coupling factor. (551 aa)
adkHypothetical protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (193 aa)
Aasi_0227Hypothetical protein. (203 aa)
Aasi_0210PROFILE: PS50928, Binding-protein-dependent transport systems inner membrane component; PFAM: PF00528, Binding-protein-dependent transport systems inner membrane component. (412 aa)
Aasi_0201Hypothetical protein; PANTHER: PTHR10746:SF2, Ribosomal protein L4;PTHR10746, Ribosomal protein L4/L1e, bacterial-type; PFAM: PF00573, Ribosomal protein L4/L1e; SUPERFAMILY: SSF52166, Ribosomal protein L4/L1e. (412 aa)
Aasi_0130Phospholipase D/Transphosphatidylase; PRINTS: PR00971, Ribosomal protein S10; PANTHER: PTHR11700:SF2, Ribosomal protein S10, bacterial;PTHR11700, Ribosomal protein S10; PFAM: PF00338, Ribosomal protein S10; SUPERFAMILY: SSF54999, Ribosomal protein S10; PRODOM: PD001272, Ribosomal protein S10; GENE3D: G3DSA:3.30.70.600, Ribosomal protein S10; TIGRFAMS: TIGR01049, Ribosomal protein S10, bacterial. (198 aa)
Your Current Organism:
Amoebophilus asiaticus
NCBI taxonomy Id: 452471
Other names: C. Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus 5a2, Candidatus Amoebophilus asiaticus str. 5a2, Candidatus Amoebophilus asiaticus strain 5a2
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