(30 nodes) Terpenoid backbone biosynthesis network (Trichoderma atroviride)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G9NVR2_HYPAI	Peptidase_M48 domain-containing protein. (366 aa)
	G9PBF7_HYPAI	Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (423 aa)
	G9PBP9_HYPAI	Putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (398 aa)
	G9NK08_HYPAI	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1152 aa)
	G9NK80_HYPAI	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1051 aa)
	G9PB05_HYPAI	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (768 aa)
	G9PAP8_HYPAI	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (236 aa)
	G9P997_HYPAI	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (471 aa)
	G9P981_HYPAI	Alpha subunit of hypothetical CAAX farnesyltransferase. (528 aa)
	G9P980_HYPAI	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (452 aa)
	G9P813_HYPAI	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (347 aa)
	G9P5U7_HYPAI	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (273 aa)
	G9P5P0_HYPAI	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (453 aa)
	G9P4J7_HYPAI	Uncharacterized protein. (365 aa)
	G9NR02_HYPAI	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (390 aa)
	G9NS82_HYPAI	Alkyl transferase; Belongs to the UPP synthase family. (367 aa)
	G9NKN0_HYPAI	CaaX prenyl protease. (301 aa)
	G9NNS1_HYPAI	Uncharacterized protein. (422 aa)
	G9NUG8_HYPAI	Uncharacterized protein. (389 aa)
	G9P253_HYPAI	Uncharacterized protein. (187 aa)
	G9P0P4_HYPAI	Nudix hydrolase domain-containing protein. (256 aa)
	G9P0H8_HYPAI	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (443 aa)
	G9P0G8_HYPAI	Putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	G9NZP0_HYPAI	Prenylcys_lyase domain-containing protein. (559 aa)
	G9NY27_HYPAI	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (470 aa)
	G9NXQ2_HYPAI	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (387 aa)
	G9NXC4_HYPAI	Uncharacterized protein. (478 aa)
	G9NWG7_HYPAI	Uncharacterized protein. (318 aa)
	G9NW50_HYPAI	Di-trans,poly-cis-decaprenylcistransferase. (327 aa)
	G9NW13_HYPAI	Uncharacterized protein. (609 aa)

Your Current Organism:

Trichoderma atroviride

NCBI taxonomy Id: 452589
Other names: T. atroviride IMI 206040, Trichoderma atroviride IMI 206040

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
G9NK08_HYPAI	G9NR02_HYPAI	G9NK08	G9NR02	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.886
G9NK08_HYPAI	G9NS82_HYPAI	G9NK08	G9NS82	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Alkyl transferase; Belongs to the UPP synthase family.	0.425
G9NK08_HYPAI	G9NUG8_HYPAI	G9NK08	G9NUG8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.418
G9NK08_HYPAI	G9NW50_HYPAI	G9NK08	G9NW50	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Di-trans,poly-cis-decaprenylcistransferase.	0.425
G9NK08_HYPAI	G9NWG7_HYPAI	G9NK08	G9NWG7	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.488
G9NK08_HYPAI	G9NXQ2_HYPAI	G9NK08	G9NXQ2	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.552
G9NK08_HYPAI	G9NY27_HYPAI	G9NK08	G9NY27	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.518
G9NK08_HYPAI	G9P0G8_HYPAI	G9NK08	G9P0G8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.534
G9NK08_HYPAI	G9P0H8_HYPAI	G9NK08	G9P0H8	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.679
G9NK08_HYPAI	G9P0P4_HYPAI	G9NK08	G9P0P4	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Nudix hydrolase domain-containing protein.	0.757
G9NK08_HYPAI	G9P253_HYPAI	G9NK08	G9P253	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.488
G9NK08_HYPAI	G9P4J7_HYPAI	G9NK08	G9P4J7	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.488
G9NK08_HYPAI	G9P5P0_HYPAI	G9NK08	G9P5P0	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.996
G9NK08_HYPAI	G9P813_HYPAI	G9NK08	G9P813	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.710
G9NK08_HYPAI	G9P980_HYPAI	G9NK08	G9P980	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.966
G9NK08_HYPAI	G9PBF7_HYPAI	G9NK08	G9PBF7	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.	0.704
G9NK08_HYPAI	G9PBP9_HYPAI	G9NK08	G9PBP9	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Putative acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.559
G9NK80_HYPAI	G9P997_HYPAI	G9NK80	G9P997	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.540
G9NKN0_HYPAI	G9NS82_HYPAI	G9NKN0	G9NS82	CaaX prenyl protease.	Alkyl transferase; Belongs to the UPP synthase family.	0.422
G9NKN0_HYPAI	G9NVR2_HYPAI	G9NKN0	G9NVR2	CaaX prenyl protease.	Peptidase_M48 domain-containing protein.	0.868