(35 nodes) Butanoate metabolism network (Kitasatospora setae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KSE_07740	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
	gabD1	Putative succinate-semialdehyde dehydrogenase. (465 aa)
	KSE_15130	Putative beta-hydroxybutyryl-CoA dehydrogenase. (288 aa)
	KSE_15420	Putative acetoacetyl-CoA synthetase. (682 aa)
	KSE_16740	Putative enoyl-CoA hydratase. (254 aa)
	KSE_18890	Putative fatty acid oxidation complex subunit alpha. (720 aa)
	KSE_18900	Putative fatty acid oxidation complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	bdh	Putative 3-hydroxybutyrate dehydrogenase; Protein synonym:D-beta-hydroxybutyrate dehydrogenase. (257 aa)
	KSE_23720	Putative acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. (295 aa)
	KSE_25120	Putative glutamate decarboxylase; Belongs to the group II decarboxylase family. (470 aa)
	hmgL	Putative hydroxymethylglutaryl-CoA lyase. (335 aa)
	adhE	Putative aldehyde dehydrogenase/alcohol dehydrogenase; Bifunctional protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (899 aa)
	pflB	Putative formate acetyltransferase; Protein synonym:pyruvate formate-lyase. (755 aa)
	sdhC1	Putative succinate dehydrogenase cytochrome b subunit. (114 aa)
	sdhD	Putative succinate dehydrogenase hydrophobic membrane anchor protein. (162 aa)
	sdhA1	Putative succinate dehydrogenase flavoprotein subunit. (580 aa)
	sdhB1	Putative succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (257 aa)
	gabD2	Putative succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa)
	KSE_33430	Putative oxidoreductase. (389 aa)
	KSE_45310	Putative 2-oxoglutarate ferredoxin oxidoreductase alpha subunit. (637 aa)
	KSE_45320	Putative 2-oxoglutarate ferredoxin oxidoreductase beta subunit. (345 aa)
	KSE_47240	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa)
	KSE_50380	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
	ilvB	Protein synonym:acetohydroxy-acid synthase large subunit. (616 aa)
	ilvN	Protein synonym:acetohydroxy-acid synthase small subunit. (177 aa)
	gabT	Putative 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
	ccr1	Putative crotonyl-CoA reductase. (445 aa)
	KSE_56530	Putative 3-hydroxyacyl-CoA dehydrogenase. (599 aa)
	KSE_61760	Putative enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
	KSE_61770	Putative enoyl-CoA hydratase. (361 aa)
	ccr3	Putative crotonyl-CoA reductase. (451 aa)
	ccr2	Putative crotonyl-CoA reductase. (445 aa)
	sdhC2	Putative succinate dehydrogenase cytochrome b subunit. (243 aa)
	sdhA2	Putative succinate dehydrogenase flavoprotein subunit. (648 aa)
	sdhB2	Putative succinate dehydrogenase iron-sulfur protein. (242 aa)

Your Current Organism:

Kitasatospora setae

NCBI taxonomy Id: 452652
Other names: K. setae KM-6054, Kitasatospora setae KM-6054, Kitasatospora setae str. KM-6054, Kitasatospora setae strain KM-6054

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KSE_07740	KSE_15130	KSE_07740	KSE_15130	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative beta-hydroxybutyryl-CoA dehydrogenase.	0.986
KSE_07740	KSE_15420	KSE_07740	KSE_15420	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetoacetyl-CoA synthetase.	0.935
KSE_07740	KSE_16740	KSE_07740	KSE_16740	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative enoyl-CoA hydratase.	0.723
KSE_07740	KSE_18890	KSE_07740	KSE_18890	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative fatty acid oxidation complex subunit alpha.	0.999
KSE_07740	KSE_18900	KSE_07740	KSE_18900	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative fatty acid oxidation complex subunit beta; Belongs to the thiolase-like superfamily. Thiolase family.	0.841
KSE_07740	KSE_23720	KSE_07740	KSE_23720	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetaldehyde dehydrogenase; Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.	0.907
KSE_07740	KSE_45310	KSE_07740	KSE_45310	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative 2-oxoglutarate ferredoxin oxidoreductase alpha subunit.	0.935
KSE_07740	KSE_45320	KSE_07740	KSE_45320	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative 2-oxoglutarate ferredoxin oxidoreductase beta subunit.	0.907
KSE_07740	KSE_47240	KSE_07740	KSE_47240	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.834
KSE_07740	KSE_50380	KSE_07740	KSE_50380	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.803
KSE_07740	KSE_56530	KSE_07740	KSE_56530	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative 3-hydroxyacyl-CoA dehydrogenase.	0.980
KSE_07740	KSE_61760	KSE_07740	KSE_61760	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.723
KSE_07740	KSE_61770	KSE_07740	KSE_61770	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative enoyl-CoA hydratase.	0.723
KSE_07740	adhE	KSE_07740	KSE_27680	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative aldehyde dehydrogenase/alcohol dehydrogenase; Bifunctional protein; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.928
KSE_07740	hmgL	KSE_07740	KSE_26840	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative hydroxymethylglutaryl-CoA lyase.	0.923
KSE_07740	pflB	KSE_07740	KSE_27690	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	Putative formate acetyltransferase; Protein synonym:pyruvate formate-lyase.	0.909
KSE_15130	KSE_07740	KSE_15130	KSE_07740	Putative beta-hydroxybutyryl-CoA dehydrogenase.	Putative acetyl-CoA acetyltransferase; Protein synonym:acetoacetyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family.	0.986
KSE_15130	KSE_15420	KSE_15130	KSE_15420	Putative beta-hydroxybutyryl-CoA dehydrogenase.	Putative acetoacetyl-CoA synthetase.	0.929
KSE_15130	KSE_16740	KSE_15130	KSE_16740	Putative beta-hydroxybutyryl-CoA dehydrogenase.	Putative enoyl-CoA hydratase.	0.969
KSE_15130	KSE_18890	KSE_15130	KSE_18890	Putative beta-hydroxybutyryl-CoA dehydrogenase.	Putative fatty acid oxidation complex subunit alpha.	0.932