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A0A0X8HUP7 A0A0X8HUP7 A0A0X8HR67 A0A0X8HR67 A0A0X8HR29 A0A0X8HR29 A0A0X8HQZ8 A0A0X8HQZ8 A0A120K2L3 A0A120K2L3 A0A120K2I5 A0A120K2I5 A0A120K1X3 A0A120K1X3 A0A120K1W1 A0A120K1W1 AW171_hschr28 AW171_hschr28 A0A120K126 A0A120K126 A0A120K0V5 A0A120K0V5 A0A109V0R5 A0A109V0R5 A0A109V0G3 A0A109V0G3 A0A109V0B3 A0A109V0B3 A0A109UZZ8 A0A109UZZ8 A0A109UYW0 A0A109UYW0 NAT10 NAT10 NCS2 NCS2 A0A109UY84 A0A109UY84 A0A109UXM8 A0A109UXM8 A0A109UXB3 A0A109UXB3 A0A109UX96 A0A109UX96 A0A109UX69 A0A109UX69 AW171_hschr286 AW171_hschr286 AW171_hschr216 AW171_hschr216 TRM8 TRM8 A0A0X8HW71 A0A0X8HW71 NCS6 NCS6 A0A0X8HVR4 A0A0X8HVR4 A0A0X8HV74 A0A0X8HV74 A0A0X8HV36 A0A0X8HV36 A0A0X8HUN5 A0A0X8HUN5 A0A0X8HTR8 A0A0X8HTR8 A0A0X8HTP4 A0A0X8HTP4 A0A0X8HTH8 A0A0X8HTH8 ALA1 ALA1 A0A0X8HT49 A0A0X8HT49 A0A0X8HSX1 A0A0X8HSX1 A0A0X8HSU9 A0A0X8HSU9 A0A0X8HRR9 A0A0X8HRR9 A0A0X8HRC4 A0A0X8HRC4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene co-occurrence
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A0A0X8HUP7Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (634 aa)
A0A0X8HR67Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1322 aa)
A0A0X8HR29HCL267Cp; Belongs to the RNR ribonuclease family. (986 aa)
A0A0X8HQZ8HDL363Wp. (518 aa)
A0A120K2L3HFR048Wp; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (684 aa)
A0A120K2I5HFL180Wp. (445 aa)
A0A120K1X3HCL307Wp. (659 aa)
A0A120K1W1HCL347Wp. (500 aa)
AW171_hschr28HBL397Wp. (273 aa)
A0A120K126tRNA (guanine(26)-N(2))-dimethyltransferase. (550 aa)
A0A120K0V5HBL168Wp. (455 aa)
A0A109V0R5HGL017Wp. (1003 aa)
A0A109V0G3HHR179Cp; Belongs to the CGI121/TPRKB family. (174 aa)
A0A109V0B3HHL197Wp. (993 aa)
A0A109UZZ8Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (1048 aa)
A0A109UYW0HCL479Wp. (515 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1055 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (495 aa)
A0A109UY84HCL447Wp. (729 aa)
A0A109UXM8D-aminoacyl-tRNA deacylase. (152 aa)
A0A109UXB3HBR355Wp. (302 aa)
A0A109UX96HBL070Wp; Belongs to the class-I aminoacyl-tRNA synthetase family. (532 aa)
A0A109UX69HBR295Wp. (1667 aa)
AW171_hschr286tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37; Belongs to the IPP transferase family. (429 aa)
AW171_hschr216HBL389Cp. (284 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (281 aa)
A0A0X8HW71HHL144Cp; Belongs to the class-I aminoacyl-tRNA synthetase family. (1072 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (373 aa)
A0A0X8HVR4Lysine--tRNA ligase. (587 aa)
A0A0X8HV74HGL216Wp. (406 aa)
A0A0X8HV36HFR114Cp. (266 aa)
A0A0X8HUN5Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (419 aa)
A0A0X8HTR8HER027Wp. (375 aa)
A0A0X8HTP4HFL215Wp. (269 aa)
A0A0X8HTH8HEL086Wp. (298 aa)
ALA1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (956 aa)
A0A0X8HT49HEL307Wp. (459 aa)
A0A0X8HSX1HDR098Cp. (466 aa)
A0A0X8HSU9Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (558 aa)
A0A0X8HRR9HDL489Cp. (499 aa)
A0A0X8HRC4HCL132Wp. (670 aa)
Your Current Organism:
Eremothecium sinecaudum
NCBI taxonomy Id: 45286
Other names: ATCC 58844, CBS 8199, CCRC 21344, CCRC:21344, DAOM 187446, E. sinecaudum, Eremothecium sinecaudum (Holley) Kurtzman, Holleya sinecauda, NRRL Y-17231, Nematospora sinecauda
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