(44 nodes) Polycystin cation channel network (Nematostella vectensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRPM2	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species. (1551 aa)
	v1g143948	Predicted protein; Belongs to the potassium channel family. (207 aa)
	v1g7548	Predicted protein. (130 aa)
	v1g2522	Predicted protein. (123 aa)
	v1g152227	Predicted protein. (114 aa)
	v1g224451	Predicted protein. (327 aa)
	v1g116534	Predicted protein; Belongs to the potassium channel family. (372 aa)
	v1g112097	Predicted protein. (413 aa)
	v1g20472	Predicted protein. (866 aa)
	v1g170705	Predicted protein. (1794 aa)
	ShakR12	Potassium channel; Belongs to the potassium channel family. (445 aa)
	v1g122010	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1534 aa)
	v1g122516	Predicted protein. (534 aa)
	v1g246935	Predicted protein. (659 aa)
	v1g132320	Predicted protein; Belongs to the potassium channel family. (367 aa)
	v1g112003	Predicted protein. (133 aa)
	v1g232965	Predicted protein. (683 aa)
	v1g244083	Predicted protein. (691 aa)
	v1g21409	Predicted protein. (633 aa)
	v1g5341	Predicted protein. (133 aa)
	v1g137041	Predicted protein. (135 aa)
	v1g248149	Predicted protein. (1148 aa)
	v1g208071	Predicted protein; Belongs to the potassium channel family. (454 aa)
	v1g28822	Predicted protein. (127 aa)
	v1g100508	Predicted protein. (475 aa)
	v1g21552	Predicted protein. (463 aa)
	v1g98527	Predicted protein. (858 aa)
	v1g204314	Predicted protein. (769 aa)
	v1g88459	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1478 aa)
	v1g67036	Predicted protein. (120 aa)
	v1g85800	Predicted protein. (482 aa)
	v1g85827	Predicted protein; Belongs to the potassium channel family. (374 aa)
	v1g198653	Predicted protein; Belongs to the potassium channel family. (417 aa)
	v1g198568	Predicted protein. (2702 aa)
	v1g85027	Predicted protein. (121 aa)
	v1g238969	Predicted protein. (780 aa)
	v1g31537	Predicted protein. (589 aa)
	v1g83487	Predicted protein. (118 aa)
	v1g45640	Predicted protein. (122 aa)
	v1g82787	Predicted protein. (130 aa)
	v1g197088	Predicted protein; Belongs to the transient receptor (TC 1.A.4) family. (571 aa)
	v1g81127	Predicted protein. (525 aa)
	v1g196807	Predicted protein. (3390 aa)
	v1g79500	Predicted protein. (216 aa)

Your Current Organism:

Nematostella vectensis

NCBI taxonomy Id: 45351
Other names: N. vectensis, starlet sea anemone

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TRPM2	v1g100508	A7T1N0	A7S163	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.602
TRPM2	v1g21552	A7T1N0	A7S161	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.602
TRPM2	v1g232965	A7T1N0	A7SB72	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.467
TRPM2	v1g244083	A7T1N0	A7SB70	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.462
TRPM2	v1g246935	A7T1N0	A7SRH3	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.462
TRPM2	v1g81127	A7T1N0	A7RH64	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.462
TRPM2	v1g85800	A7T1N0	A7RLE3	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	Predicted protein.	0.467
v1g100508	TRPM2	A7S163	A7T1N0	Predicted protein.	Transient receptor potential cation channel subfamily M member-like 2; Nonselective, voltage-independent cation channel that mediates Ca(2+) and to a lesser extent Na(+) influx, leading to increased cytoplasmic Ca(2+) levels. Functions as ligand-gated ion channel. Binding of ADP-ribose causes a conformation change; the channel is primed but still requires Ca(2+) binding to trigger channel opening. May have ADP-ribose pyrophosphatase activity which reduces ADP-ribose levels induced by oxidative stress, thus preventing the channel activation by reactive oxygen species.	0.602
v1g100508	v1g81127	A7S163	A7RH64	Predicted protein.	Predicted protein.	0.452
v1g112097	v1g45640	A7SBB8	A7RJ03	Predicted protein.	Predicted protein.	0.410
v1g122010	v1g122516	A7SKR1	A7SLD1	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Predicted protein.	0.681
v1g122010	v1g170705	A7SKR1	A7SHI0	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Predicted protein.	0.690
v1g122010	v1g2522	A7SKR1	A7T7Q0	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Predicted protein.	0.543
v1g122010	v1g88459	A7SKR1	A7RP56	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.558
v1g122516	v1g122010	A7SLD1	A7SKR1	Predicted protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.681
v1g122516	v1g170705	A7SLD1	A7SHI0	Predicted protein.	Predicted protein.	0.550
v1g122516	v1g2522	A7SLD1	A7T7Q0	Predicted protein.	Predicted protein.	0.842
v1g122516	v1g79500	A7SLD1	A7RF81	Predicted protein.	Predicted protein.	0.567
v1g122516	v1g88459	A7SLD1	A7RP56	Predicted protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.669
v1g137041	v1g5341	A7SXR5	A7SXR4	Predicted protein.	Predicted protein.	0.432